First Synthesis of the Novel Triazolo[3,4-
 b
 ][1,3,4]Thiadiazoles and Triazolo[3,4-
 b
 ][1,3,4]Thiadiazines Linked Chromeno[2,3-
 b
 ]Pyridine

Ibrahim, Magdy A.; Al‐Harbi, Sami A.; Allehyani, Esam S.; Alqurashi, Esam A.; Alshareef, F. M.

doi:10.1080/10406638.2023.2173621

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…Triazolo [3,4-b][1,3,4]thiadiazine derivatives 19-22 were produced by reacting compound 1 with 2,3-dichloroquinoxaline, chloroacetonitrile, bromomalononitrile, 3-chloropen tane-2,5-dione, and ethyl 2-chloro-3-oxobutanoate in boiling DMF/TEA, respectively (Scheme 8). The acquired compounds were assessed for their antibacterial efficacy, displaying varying levels of inhibitory activity against the tested pathogens [28]. Compound 1 was subjected to benzoin treatment, resulting in the formation of 6,7diphenyl-5H- [1,2,4]triazolo [3,4-b][1,3,4]thiadiazine derivatives 18a,b [8,10] (Scheme 7).…”

Section: Cpdmentioning

confidence: 99%

“…Triazolo [3,4-b][1,3,4]thiadiazine derivatives 19-22 were produced by reacting compound 1 with 2,3-dichloroquinoxaline, chloroacetonitrile, bromomalononitrile, 3chloropentane-2,5-dione, and ethyl 2-chloro-3-oxobutanoate in boiling DMF/TEA, respectively (Scheme 8). The acquired compounds were assessed for their antibacterial efficacy, displaying varying levels of inhibitory activity against the tested pathogens [28]. In an alcoholic solution containing InCl3 as a recyclable catalyst, compound 1, aromatic aldehyde, and isocyanocyclohexane were stirred at 60 °C or subjected to MWI to afford triazolothiadiazines 23a-l [29] (Scheme 9).…”

Section: Cpdmentioning

confidence: 99%

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Synthetic Methods and Pharmacological Potentials of Triazolothiadiazines: A Review

Mostafa,

Radini,

El-Rahman

et al. 2024

Molecules

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This review article examines the synthetic pathways for triazolothiadiazine derivatives, such as triazolo[3,4-b]thiadiazines, triazolo[5,1-b]thiadiazines, and triazolo[4,3-c]thiadiazines, originating from triazole derivatives, thiadiazine derivatives, or thiocarbohydrazide. The triazolothiadiazine derivatives exhibit several biological actions, including antibacterial, anticancer, antiviral, antiproliferative, analgesic, anti-inflammatory, and antioxidant properties. The review article aims to assist researchers in creating new biologically active compounds for designing target-oriented triazolothiadiazine-based medicines to treat multifunctional disorders.

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Section: Cpdmentioning

confidence: 99%

Section: Cpdmentioning

confidence: 99%

Synthetic Methods and Pharmacological Potentials of Triazolothiadiazines: A Review

Mostafa,

Radini,

El-Rahman

et al. 2024

Molecules

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“…Studies show that 2-pyrazolines have a vital function in organic and biological chemistry [13][14][15][16], as well as being effective insecticides [17][18][19][20]. Furthermore, the pyridine ring appears in a wide range of synthetic chemistry [21,22], including agrochemicals and insecticides [23][24][25][26][27][28]. As a result of the aforementioned and continuing teamwork [29][30][31][32][33][34][35][36], we are interested in developing novel 2-pyrazoline or pyridine analogs combining pyrazolopyridine and pyrazole nuclei having molluscicidal activity against the land snail, T. pisana.…”

Section: Introductionmentioning

confidence: 99%

Novel synthesis of some heterocycles and their molluscicidal activity against the destructive land snail, Theba pisana

Abeed,

El-Emary,

Youssef

et al. 2024

Chem. Biol. Technol. Agric.

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Background Terrestrial snails, specifically Theba pisana, represent significant agricultural pests in the Mediterranean region, particularly in Egypt. They are gastropods that cause substantial damage to a variety of vegetation, rendering them important agricultural pests that result in economic losses. In response, we have developed unique and non-toxic molluscicides. The study assessed nine novel heterocycles compared with methomyl as a reference compound, to study their molluscicidal effects on T. pisana. These heterocycles include 2-pyrazolines, 2-oxocyclohex-3-ene, and 3-cyano-2-ethoxypyridine. Results The obtained data revealed that the majority of the produced chemicals were remarkably effective against T. pisana snails, exhibiting different degrees of toxicity seven days post-treatment. Methomyl exhibited the highest toxicity, followed by prop-2-en-1-one and 1-thiocarbamoyl-2-pyrazoline derivatives, with LC50 values of 44.14, 59.54, and 72.00 ppm, respectively. Conclusions These findings will inform the potential of these synthetic compounds as one of the sources for molluscicide development and their integration into pest management strategies. Graphical Abstract

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Synthetic strategies and anticancer evaluation for the novel 3-(6-heteroaryltriazolo[3,4- b ][1,3,4]thiadiazol-3-yl)chromeno [2,3- b ]pyridines

Alshaye,

Ibrahim

2024

Synthetic Communications

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First Synthesis of the Novel Triazolo[3,4- b ][1,3,4]Thiadiazoles and Triazolo[3,4- b ][1,3,4]Thiadiazines Linked Chromeno[2,3- b ]Pyridine

Cited by 5 publications

References 34 publications

Synthetic Methods and Pharmacological Potentials of Triazolothiadiazines: A Review

Synthetic Methods and Pharmacological Potentials of Triazolothiadiazines: A Review

Novel synthesis of some heterocycles and their molluscicidal activity against the destructive land snail, Theba pisana

Synthetic strategies and anticancer evaluation for the novel 3-(6-heteroaryltriazolo[3,4- b ][1,3,4]thiadiazol-3-yl)chromeno [2,3- b ]pyridines

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