Goals
To characterize patients who suffer perforation in the context of EoE and to identify predictors of perforation
Background
Esophageal perforation is a serious complication of eosinophilic esophagitis (EoE).
Methods
We conducted a retrospective cohort study of the UNC EoE clinicopathologic database from 2001–2014. Subjects were included if they had an incident diagnosis of EoE and met consensus guidelines, including non-response to a PPI trial. Patients with EoE who had suffered perforation at any point during their course were identified, and compared to EoE cases without perforation. Multiple logistic regression was performed to determine predictors of perforation.
Results
Out of 511 subjects with EoE, 10 (2.0%) had experienced an esophageal perforation. While those who perforated tended to have a longer duration of symptoms prior to diagnosis (11.4 vs. 7.0 years, p=0.13), a history of food impaction (OR 14.9; 95% CI 1.7–129.2) and the presence of a focal stricture (OR 4.6; 1.1–19.7) were the only factors independently associated with perforation. Most perforations (80%) occurred after a prolonged food bolus impaction, and only half of individuals (5/10) carried a diagnosis of EoE at the time of perforation; none occurred after dilation. Six patients (60%) were treated with non-operative management, and four (40%) required surgical repair.
Conclusion
Esophageal perforation is a rare but serious complication of eosinophilic esophagitis, occurring in approximately 2% of cases. Most episodes are due to food bolus impaction or strictures, suggesting that patients with fibrostenotic disease due to longer duration of symptoms are at increased risk.