First study of C2491T FV mutation with ischaemic stroke risk in Morocco

Diakité, Bréhima; Hamzi, Khalil; Hmimech, Wiam; Nadifi, Sellama; Gmravc,

doi:10.1007/s12041-015-0525-x

Cited by 9 publications

(9 citation statements)

References 10 publications

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“…As the present study was the first to assess the association between the C2491T FV mutation and MI, no direct comparison with the literature is possible. However, a recent study by Diakite et al (15) revealed a strong association between the T allele and TT genotype of the C2491T FV non-with the risk of ischemic stroke. Thus, the present study confirmed the role of this non-sense mutation in the pathogenesis of thromboembolic diseases.…”

Section: Discussionmentioning

confidence: 93%

“…Thus, this FV variant lacks ~90% of the B domain and the complete light chain (14). Recently, a case control study by our group showed that the C2491T FV mutation was associated with an increased risk of cerebral ischemia and that this risk was doubled in subjects carrying two morbid alleles (15). Furthermore, Hamzi et al (16) assessed the frequency of the C2491T FV mutation in a healthy Moroccan population [72.7% CC (wild-type), 23.7% CT (heterozygous mutated type) and 3,6% TT (homozygous mutated type); 84.54% C allele and 15.46% T allele).…”

Section: Introductionmentioning

confidence: 99%

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G2691A and C2491T mutations of factor V gene and pre-disposition to myocardial infarction in Morocco

et al. 2016

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Coagulation factor Leiden mutation has been described as a common genetic risk factor for venous thrombosis; however, this mutation was reported to be practically absent in an African population. Recently, a novel non-sense mutation in the gene encoding factor V has been associated with the risk of occurrence of cardio-cerebrovascular diseases such as stroke and venous thrombosis. The aim of the present study was to investigate whether the factor V Leiden (FVL) and C2491T non-sense mutations are associated with the risk of developing myocardial infarction. Genotyping of FVL and C2491T FV was performed using the polymerase chain reaction restriction fragment length polymorphism method on a sample of 100 patients with myocardial infarction as well as 211 controls. In the study population, the frequency of the FVL mutation was practically zero. However, with regard to the C2491T mutation, the TT genotype was associated with an increased risk of myocardial infarction [odds ratio (OR)=3.16, 95% confidence interval (CI): 1.29-7.71, P=0.03]. A significant association between the C2491T FV mutation and the risk of myocardial infarction was identified using recessive (OR=2.74, 95% CI: 1.14-6.58, P=0.04), dominant (OR=1.85, 95% CI: 1.13-3.04, P=0.02) and additive (OR=1.88, 95% CI: 1.25-2.80, P=0.004) models. Furthermore, a positive correlation was found between the presence of the C2491T FV mutation and hypertension (P=0.02), which is associated with myocardial infarction. In conclusion, the results of the present study suggested that the C2491T non-sense mutation of the FV gene may be a risk factor for myocardial infarction in a Moroccan population.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

G2691A and C2491T mutations of factor V gene and pre-disposition to myocardial infarction in Morocco

et al. 2016

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“…Studies included in the present critical review of the literature have revealed several risk factors associated with cerebral ischemia in the local populations of interest. Indeed, high blood pressure (HBP), diabetes, smoking and heart disease were the four main risk factors listed and are as follows: HBP was reported in ( n = 20) studies (31 to 65.4%) [13, 15, 17, 18, 20, 21, 23, 25–28, 30, 33, 35–38, 40–42], diabetes in ( n = 20) studies (12–41.8%) [13, 15, 17, 18, 20, 21, 23, 25–28, 30, 33, 35–38, 40–42], cardiac diseases in 14 studies (7–44.3%) [13, 15, 17, 20, 21, 23, 25–28, 30, 33, 35, 42], atrial fibrillation as associated heart disease was specified in 9 studies (2,5–22%), and smoking in ( n = 19) studies (4–41.8%) [13, 15, 17, 18, 20, 21, 23, 25–28, 30, 33, 35, 37, 38, 40–42].…”

Section: Resultsmentioning

confidence: 99%

“…In addition to these risk factors, other risk factors have been reported such as dyslipidemia in ( n = 16) studies (0–61.8%) [13, 15, 17, 18, 20, 23, 25–28, 30, 33, 35–37, 42], obesity in ( n = 6) studies (10.7–26.1%) [13, 17, 18, 26, 30, 35], the notion of a previous stroke was noted in ( n = 10) hospital series (5–26.6%) [13, 15, 23, 25–28, 30, 32, 35], alcoholism in ( n = 10) studies [13, 15, 20, 25, 32, 33, 35, 38, 40, 41], oral contraception in ( n = 3) studies (6.6–12.2%) [30, 32, 33], and migraine in a single study at 6.5% [30].…”

Section: Resultsmentioning

confidence: 99%

Ischemic stroke in Morocco: a systematic review

et al. 2019

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BackgroundThe aim of this systematic review is to determine the epidemiological and etiological profiles, the influential factors of the prehospital delay, thrombolysis management, the acute and 3-month mortality rate and the genetic aspect of ischemic stroke in Morocco.MethodsThe present work is a systematic review that was conducted according to the recommendations of the “Preferred reporting items for systematic reviews and meta-analysis”. We used Pubmed, Sciencedirect, Scopus, Clinicalkey, and Google scholar databases for the raking of the gray literature during the time frame 2009 and 2018. The protocol of the review was registered in the PROSPERO register (CRD42018115206).These studies were analyzed based on: Age, sex ratio, risk factors, etiological profile according to Trial of ORG classification 10,172 in Acute Stroke Treatment, prehospital delay average and its influential factors, thrombolyzed patients’ proportion, acute and 3-month mortality and the genetic factors of ischemic stroke in Morocco.ResultsTwenty-nine (n = 29) studies were selected. The average age ranged from 49 ± 15.2 to 67.3 ± 9.9 years old. Moreover, we reported male predominance within all ages in 13 studies. High blood pressure, diabetes, smoking and heart disease were the four identified main risk factors by the prementioned studies. Atherosclerosis and cardioembolic were the main described etiologies of cerebral ischemia, and the average prehospital time ranged from 26 to 61.9 h. The proportion of thrombolysed patients ranged from 1.8% to 2.9%, the mortality rate varied in the acute phase from 3 to 13%, and the 3-month mortality ranged from 4.3 to 32.5%. It is also important to highlight that most of these studies, which were conducted in hospital environment, have a reduced sample size and no confidence interval.ConclusionsIschemic stroke is affecting more likely the young population with male predominance. Moreover, the long prehospital delay and the low proportion of thrombolysed patients are alarming. This indicates the need to investigate in depth the key factors influencing the access to care for Moroccan patients in order to improve the management of this neurologic deficit in Morocco.

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“…In addition, another genetic study byDiakite et al (2015) evaluated the association of the FVF C2491T mutation with the risk of IS, suggesting that carriers of the mutated T allele were associated with a high risk of IS. But this risk was 8.95 times higher when the subject had the TT genotype (P <0.0001) and 4.08 times higher with the CT genotype, and they concluded that the FVF C2491T mutation could be a genetic risk factor for IS in the Moroccan population[25].…”

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confidence: 99%

Ischemic stroke in Morocco: A systematic review

Kharbach

Obtel

Lahlou

et al. 2019

Preprint

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Background: The aim of this systematic review is to determine; the epidemiological and etiological profiles, the influential factors of the prehospital delay, thrombolysis management, the acute and 3-month mortality rate and the genetic aspect of ischemic stroke in Morocco.Methods: The present work is a systematic review that was conducted according to the recommendations of the "Preferred reporting items for systematic reviews and meta-analysis". We used Pubmed, Sciencedirect, Scopus, Clinicalkey, and Google scholar databases for the raking of the gray literature during the period between 2009 and 2018. The protocol of the review was registered in the PROSPERO register (CRD42018115206). These studies were analyzed based on: Age, sex ratio, risk factors, etiological profile according to Trial of ORG classification 10172 in Acute Stroke Treatment, prehospital delay average and it’s influential factors, thrombolyzed patients proportion, acute and 3-month mortality and the genetic factors of ischemic stroke in Morocco. Results: Twenty-nine (n = 29) studies were selected. The average age ranged from 49±15.2 to 67.3 ± 9.9 years old. Moreover, we reported male predominance within all ages in 13 studies. High blood pressure, diabetes, smoking and heart disease were the four identified main risk factors by these studies. Atherosclerosis and cardioembolic were the main described etiologies of cerebral ischemia, and the average prehospital time ranged from 26 to 61.9 hours. The proportion of thrombolysed patients ranged from 1.8% to 2.9%, the mortality rate varied in the acute phase from 3 to 13%, and the 3-month mortality ranged from 4.3 to 32.5%. It is also important to highlight that most of these studies have a reduced sample size, conducted in hospital environment, and no confidence interval was reported. Conclusions: Ischemic stroke is affecting more likely the young population with male predominance. Moreover, the long prehospital delay and the low proportion of thrombolysed patients are alarming. Indicating, thus, the need to investigate in depth the key factors influencing the access to care for Moroccan patients in order to improve the management of this neurologic deficit in Morocco. Key words: Ischemic stroke, Trial of ORG classification 10172 in Acute Stroke Treatment classification, prehospital delay, thrombolysis, Morocco.

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First study of C2491T FV mutation with ischaemic stroke risk in Morocco

Cited by 9 publications

References 10 publications

G2691A and C2491T mutations of factor V gene and pre-disposition to myocardial infarction in Morocco

G2691A and C2491T mutations of factor V gene and pre-disposition to myocardial infarction in Morocco

Ischemic stroke in Morocco: a systematic review

Ischemic stroke in Morocco: A systematic review

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