First sexual intercourse and high parity are the most influential factors of precancerous cervical lesion

Abstract

Objectives: to analyze the relationship between characteristics, parity and maternal reproductive history with the risk of cervical pre-cancerous lesions.Materials and Methods: Cross Sectional Survey, in 2016 Non-Communicable Disease study, with a population of women aged 25-64 years, living in urban areas. A total of 1,547 samples were selected from the census blocks that were prepared to IVA examination. The variables in this article are maternal characteristics, menarche, age of first sexual intercourse, number of partners, parity and contraceptive use, as independent variables and cervical pre-cancerous lesions as dependent variables.Results: Factors influencing cervical pre-cancerous lesions were: Menarche with a value of P = 0.018; Age of first sexual intercourse with a value of P = 0,000; Number of sexual partners with a value of P = 0.023; and parity with a value of P = 0.049. Multivariate test results show that the age of first time having sex less than 20 years has a 2.3 risk; Mothers with high parity (> 4 children) and having more than one sexual partner have a 16.5 risk.Conclusion: Menarche, age of first sexual intercourse, number of sexual partners and parity affect the incidence of cervical cancerous lesions. The most influential Factors are: the age of first sexual intercourse less than 20 years, and mothers with high parity who have more than one sexual partner.

Eliminating HPV DNA Positive Result with Large Loop Excision of the Transformation Zone (LLETZ)/Loop Electrosurgical Excision Procedure (LEEP) in Precancerous Cervical Lesions

“…Women who often give birth (or give birth to many children) automatically experience injuries to their reproductive organs including the cervix, especially in women with short birth intervals, these injuries often include a higher risk of HPV infection. 13,14 HPV is a member of the Papillomaviridae family which is divided into 2 subfamilies with more than 50 genera, however, only 5 genera (classifi cation based on L1 sequence) are associated with infection in humans namely Alpha-, Beta-, Gamma-, Nu-, and Mu-papillomavirus. In this study, 24 samples (100%) of patients with cervical precancerous lesions had positive HPV DNA, with a high-risk type of 54.2% and a low risk of 41.7% and 4.2% other types of HPV.…”

The Risks of Sexual and Reproductive Activity on the Occurrence of Cervical Cancer in Central Sulawesi Province: Case Study of patients of Undata Hospital

“…The analysis showed that respondents with more than 3 pregnancies had a 4 times greater risk of suffering from cervical cancer than those with less than or equal to 3 pregnancies (OR = 4,000; CI 95% 1.712-9.346). Based on research Ashar H et al (2020) (17), the results of multivariate analysis showed that mothers with high parity (> 4 children) and having more than one sexual partner had the highest risk of precancerous lesions of 16.5 times. A study with a meta-analysis was also conducted to see the relationship between parity and cervical cancer, and the results showed that women with high parity had a 2.65 times higher chance of developing cervical cancer compared to the control group (OR=2.65, CI 95% 2.08-3.38) (18).…”