First serological evidence of hantavirus among febrile patients in Mozambique

Chau, Ramalho Maximiano; Bhatt, Nilesh; Manhiça, Ivan; Cândido, Sandra; Deus, Nilsa de; Guiliche, Onélia; Tivane, Almiro; Evaristo, Lara Virgínia; Guterres, Alexandro; Monteiro, Vanessa; Fernandes, Jorlan; Oliveira, Renata Carvalho de; Lemos, Elba Regina Sampaio de; Gudo, Eduardo Samo

doi:10.1016/j.ijid.2017.06.001

Cited by 5 publications

(5 citation statements)

References 30 publications

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“…Due to the non-pathognomonic nature of CCHF clinical presentations, the disease has a wide range of possible etiologies including other VHFs, such as HFRS.In the present study, serological evidence of Hantavirus infection was observed among CCHF-negative cases. However, in agreement with previous studies,8,14,15 none of the specimens was positive for a Hantavirus genome. This may be explained by the fact that viremia persists only for a few days14 and a viral RNA cannot be detected in the majority of the infections, especially in mild cases 16,17.…”

supporting

confidence: 92%

“…4 Recently, the significance of Hantaviruses to public health has intensified notably as an increasing number of infections in humans and reservoirs has been reported from different countries in the Americas and Eurasia. 4,7,8 About 150,000 to 200,000 cases of Hantavirus diseases are diagnosed in Asia and Europe each year 4 where the epidemiology is mostly studied, as well as in the Americas and Far East Asia. 4,7,8 However, little is known about their circulation in Africa, the Indian subcontinent, and the Middle East.…”

mentioning

confidence: 99%

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Hantavirus infection in Iranian patients suspected to viral hemorrhagic fever

Salehi‐Vaziri

Kaleji

Fazlalipour

et al. 2019

Journal of Medical Virology

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Background: Hantaviruses are a group of emerging pathogens causing hemorrhagic fever with renal syndrome and Hantavirus cardiopulmonary syndrome in human. This study was conducted to investigate Hantavirus infection among Iranian viral hemorrhagic fever suspected patients. Methods: From April 2014 to June 2016, 113 cases from 25 different provinces of Iran were analyzed for Hantavirus infection by IgM/IgG ELISA and pan‐Hantavirus RT‐PCR tests. Results: Although, viral genome was detected in none of the subjects, IgM and IgG antibodies were detected in 19 and 4 cases, respectively. Differentiation of the anti‐Hantavirus antibodies according to virus species by EUROLINE Anti‐Hantavirus Profile Kit revealed three Puumala virus IgM positive, one Hantaan virus IgM positive, one Hantaan virus IgM borderline, and two Puumala virus IgG borderline cases. Conclusions: This study demonstrates the circulation of Hantaviruses in Iran and calls for further investigations of these life‐threatening viruses in the country.

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supporting

confidence: 92%

mentioning

confidence: 99%

Hantavirus infection in Iranian patients suspected to viral hemorrhagic fever

Salehi‐Vaziri

Kaleji

Fazlalipour

et al. 2019

Journal of Medical Virology

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“…In addition, the use of only serological testing minimizes reliability due to other potential infections in the region that tend to produce cross‐reactive antibodies. A recent case study of 200 febrile patients, attending the out patient appointment clinic at a primary health care center at Mozambique, demonstrated the presence of IgM, and IgG antibodies in the serum samples of four patients . In the European continent, Eastern Europe accounts for most of the infections with an average of 7476 cases reported between 1999 and 2008.…”

Section: Epidemologymentioning

confidence: 99%

Hantavirus induced cardiopulmonary syndrome: A public health concern

Llah

Mir²,

Sharif

et al. 2018

Journal of Medical Virology

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Hantavirus cardiopulmonary syndrome is characterized by pulmonary capillary leakage and alveolar flooding, resulting in 50% mortality due to fulminant hypoxic respiratory failure. In addition, depression of cardiac function ensues, which complicates the picture with cardiogenic shock. Early diagnosis and appropriate use of extracorporeal membrane oxygenation (ECMO) are amongst the lifesaving interventions in this fatal illness. However, a recent case report demonstrates that implementation of high volume continuous hemofilteration along with protective ventilation reverses the cardiogenic shock within few hours in hantavirus infected patients. This review article is focused on the recent advances in clinical features, diagnosis, management, epidemiology, and pathogenesis of hantavirus induced cardiopulmonary syndrome. It provides information for clinicians to help in correct diagnosis during the early stages of viral infection that could improve the prognosis of this viral illness.

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“…A surveillance system was established in 2015 to monitor the occurrence of arboviruses and other emerging viruses as well as building capacity for early detection of these emerging pathogens. Data from the established surveillance for emerging viruses found cases of dengue, chikungunya, Rift Valley fever, hantavirus, and Crimean-Congo hemorrhagic fever across different sentinel sites (Chau et al, 2017;Mugabe et al, 2018;Muianga et al, 2017;Oludele et al, 2017). These results have driven the establishment of diagnostic capacity for early detection of and rapid response to emerging viruses in Mozambique.…”

Section: Alphaviruses (Chikungunya): Molecular Biology Pathogenesismentioning

confidence: 99%

Third Tofo Advanced Study Week on Emerging and Re-emerging Viruses, 2018

et al. 2019

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Singapore, and the USA. Meeting sessions covered aspects of the epidemiology, diagnosis, molecular and structural biology, vaccine development, and antiviral drug discovery for emerging RNA viruses that are current threats in Africa and included flaviviruses (dengue and Zika), alphaviruses (chikungunya), coronaviruses, filoviruses (Ebola), influenza viruses, Crimean Congo hemorrhagic fever virus, Rift Valley fever Virus, Lassa virus, and others. Data were presented on recent flavivirus and/or chikungunyavirus outbreaks in Angola, Burkina Faso, and Mozambique. In addition, these viruses are endemic in many sub-Saharan countries. The TASW series on emerging viruses is unique in Africa and successful in promoting collaborations between researchers in Africa and other parts of the world, as well as among African scientists. This report summarizes the lectures held at the meeting and highlights advances in the field.

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First serological evidence of hantavirus among febrile patients in Mozambique

Abstract: The findings of this study demonstrate human exposure to hantavirus in Mozambique for the first time; however, further studies should be conducted to investigate its clinical implications.

Cited by 5 publications

References 30 publications

Hantavirus infection in Iranian patients suspected to viral hemorrhagic fever

Hantavirus infection in Iranian patients suspected to viral hemorrhagic fever

Hantavirus induced cardiopulmonary syndrome: A public health concern

Third Tofo Advanced Study Week on Emerging and Re-emerging Viruses, 2018

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