First Series of Combined Heart &amp; Lung Transplantation from India

Rahulan, V.; Yadav, Pavan; Jindal, Apar; Narayanan, Arul; Balasubramani, G.K.; Dutta, Parikshit; Attawar, Sandeep

doi:10.1016/j.healun.2020.01.505

The Journal of Heart and Lung Transplantation

2020

DOI: 10.1016/j.healun.2020.01.505

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First Series of Combined Heart & Lung Transplantation from India

V. Rahulan¹,

Pavan Yadav²,

Apar Jindal³

et al.

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2021

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“… 9 Combined heart and lung transplantation for pulmonary hypertension in India is still in its nascency but promising outcomes have been reported. 10 Being a developing country, India faces unique challenges such as unpredictable organ transportation, inconsistent medication supply and limited opportunities for post-transplant follow-up due to multitude of patient and institutional socioeconomic barriers. India still grapples with tropical infections, water-borne illnesses and tuberculosis, all of which can severely affect post-transplant survival independent of the traditional predictors such as ischemic time or hemodialysis.…”

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confidence: 99%

Heart transplantation in India

Vaidya

2021

Indian Heart Journal

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mentioning

confidence: 99%

Heart transplantation in India

Vaidya

2021

Indian Heart Journal

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The evolution of lung transplantation in India and the current scenario

Sunder

2021

Indian J Thorac Cardiovasc Surg

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Challenges, experiences, and postoperative outcomes in setting up first successful lung transplant unit in India

Rahulan¹,

Shah²,

Yadav³

et al. 2021

Lung India

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Background: Lung transplantation (LT) has emerged as a definitive cure for a plethora of end-stage lung diseases (ESLDs). With improvements in immune-suppression protocols, the posttransplantation survival rates have gone up. Aim: The study reported the initial experience of the India's single largest lung transplant program on clinicopathological profile, procedures, challenges encountered, and outcomes. Settings and Design: A retrospective analysis was done from data available at three centers of Institute of Heart and Lung Transplant, Gleneagles Global Hospitals across Chennai, Bengaluru, and Mumbai. Materials and Methods: A total of 132 patients underwent lung (single or bilateral) or combined heart and lung transplant between April 2017 and March 2020. All the participants had 30 days' follow-up. Postoperative complications, graft rejection, and 30-day mortality were reported. Kaplan–Meier survival analysis and logistic regression analysis were performed. Statistical Analysis Used: Kaplan–Meier survival and binary logistic regression was performed. Results: Interstitial lung diseases, 65.91%, were the most common diagnosis. Bilateral LT (81.3%) was the most common type of LT performed. Grade III primary graft dysfunction was observed in 16 (12.1%). Distal airway stenosis (21.97%) was the most common complication followed by anastomotic stenosis (14.30%). Gram-negative bacterial sepsis (52%) was the leading cause of death. Cumulative probability of survival at 1 month was 0.85 (95% confidence interval [CI] 0.80–0.92), and at 1 year, it was 0.78 (95% CI, 0.72–0.86). Conclusion: This study establishes the fact that despite multiple challenges, LT is a viable option for selected patients with ESLDs in India and should encourage early referrals to a transplant center.

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First Series of Combined Heart & Lung Transplantation from India

Cited by 3 publications

References 0 publications

Heart transplantation in India

Heart transplantation in India

The evolution of lung transplantation in India and the current scenario

Challenges, experiences, and postoperative outcomes in setting up first successful lung transplant unit in India

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