Background: In a recently reported randomized trial, lowdose
intravenous liposomal amphotericin B (L-AmB) reduced
the incidence of invasive fungal infections (20.2
vs. 4.6%, p < 0.001) in high-risk patients with hematological
malignancies and prolonged neutropenia. Patients
and Methods: In the present study, we performed a retrospective
cost-benefit analysis of L-AmB prophylaxis
from the hospital perspective. Results: Ninety-nine patients
were eligible; baseline characteristics were balanced
for age, sex, underlying disease, and duration of
neutropenia. The mean duration of hospitalization was
42.9 days and 52.3 days in the prophylaxis arm and
in patients without antifungal prophylaxis, respectively
(p = 0.096). The L-AmB prophylaxis was associated with
additional costs of approximately EUR 630 per patient.
However, total medication costs (including L-AmB prophylaxis)
were EUR 1,219 and EUR 2,815 in patients with
L-AmB prophylaxis and in patients in the control arm, respectively
(p < 0.001). When involving also costs for
medical procedures, the L-AmB prophylaxis reaches a
positive net benefit of EUR 1,094 per patient. Conclusions:
Our data shows that antifungal prophylaxis, e.g.
with L-AmB, can be a safe and effective strategy to reduce
the frequency of invasive fungal infections in selected
high-risk patients and to obtain significant cost
savings for the hospital.
Cost-Benefit Assessment of Antifungal Prophylaxis with
Liposomal Amphotericin B in Neutropenic Patients
Olaf Penacka Thomas Reinholdb Eckhard Thiela Igor Wolfgang Blaua
a Department of Hematology, Oncology, and Transfusion Medicine, Charité Campus Benjamin Franklin,
bInstitute for Social Medicine, Epidemiology and Health Economics, Charité Campus Mitte, Berlin, Germany