First Results of Laparoscopic Pressurized Intraperitoneal Aerosol Chemotherapy (Pipac) in Treatment for Peritoneal Carcinomatosis in Patients With Gastric Cancer

Abstract

The results of treatment of gastric cancer with peritoneal dissemination are not very comforting. The average life expectancy of patients after diagnosis is less than 6 months. Methods of systemic treatment are ineffective. The most effective strategy is regional treatment, a special place in recent years has taken intraperitoneal chemotherapy with low-dose Cisplatin and Doxorubicin administered as a pressurized aerosol (PIPAC). This article presents the analysis of the first results of treatment of patients with gastric cancer with peritoneal carcinomatosis, which was used PIPAC at conventional regimens (standard for this technique, low-dose cytostatics, exposure time and intraperitoneal pressure) and in the experimentally developed effective regimen. The developed PIPAC regimen proposed by the authors proved its safety and objectively more effective than the standard for such parameters as objective tumor response, histological response and overall survival of patients. The study will be continued to obtain statistically reliable results.