First Reported Infections Caused by Three Newly Described Genera in the Family Xanthomonadaceae

Abstract

Members of the family of Xanthomonadaceae are typically characterized as environmental organisms. With the exception of Stenotrophomonas maltophilia, these organisms are infrequently implicated as human pathogens. We describe three cases of central venous catheter-associated bloodstream infections caused by Dokdonella koreensis, Aquimonas voraii, and a Luteibacter sp., all newly named genera within the family Xanthomonadaceae. The three patients all had histories of underlying hematological disorders, presented with fever, and recovered fully following treatment. These isolates required 16S rRNA gene sequencing for identification and, unlike S. maltophilia, demonstrated susceptibility to most antibiotics tested. This report represents the first description of human infections caused by these organisms.

Current microbiology of percutaneous endoscopic gastrostomy tube (PEG tube) insertion site infections in patients with cancer

“…Enterobacteriaceae and most facultative anaerobes were identified using the VITEK 1 System (BioMerieux, Marcy l'Etoile, France). For organisms with questionable identification, 16 s sequencing was used [15]. Susceptibility testing was performed using the VITEK 1 system using GPS card 119 and GNS card 132 and 134, or E-test method for non-fermenters, fastidious organisms, and enterococci (AB Biodisk, Solna, Sweden).…”

Epiphytic bacterial communities on two common submerged macrophytes in Taihu Lake: diversity and host-specificity

“…The H. verticillata community supports bacteria closest to Dokdonella, found on humic-based biofilms (Rodrigues et al, 2010) and root tissues of maize (Haichar et al, 2008). Some strains of Dokdonella are human pathogens (Lasala et al, 2007). A new facultative autotrophic hydrogenoxidizing species, Betaproteobacterium Hydrogenophaga sp.…”

Dokdonella Koreensis Bacteremia: A Case Report and Review of the Literature

“…Little is known about Dokdonella colonization in the hospital environment or pathogenicity in humans. To our knowledge, there has been only one previously published case of D koreensis infection in humans reported in the English-language medical literature ( 8 ). Similar to our case, the patient was immunocompromised (bone marrow transplant recipient) and had a bloodstream infection related to a centrally inserted venous catheter.…”