First reported human isolation of Staphylococcus delphini

Magleby, Reed; Bemis, David A.; Kim, David; Carroll, Karen C.; Castanheira, Mariana; Kania, Stephen A.; Jenkins, Stephen G.; Westblade, Lars F.

doi:10.1016/j.diagmicrobio.2019.01.014

Cited by 23 publications

(14 citation statements)

References 23 publications

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“…This may also hold true for other staphylococci belonging to the "Staphylococcus intermedius group" as some of these bacteria bear homologues of staphylococcal adsA and nuclease-encoding genes in their core genomes. Interestingly, some of these species (i.e., Staphylococcus intermedius, Staphylococcus cornubiensis, or Staphylococcus delphini) can cause abscesses, wound infections, or bacteremia in humans raising the possibility that these bacteria may also use a Nuc/AdsA signaling cascade to perturb host immune cell assemblies during pathogenesis [51][52][53][54]. Consequently, pharmacological inhibition or antibody-based targeting of Nuc/AdsA in combination with appropriate antibiotic treatment might become a suitable strategy to improve clinical outcomes of animal or human infections caused by MRSP and related pathogenic staphylococci that exploit the toxigenic properties of dAdo.…”

Section: Discussionmentioning

confidence: 99%

Methicillin-resistant Staphylococcus pseudintermedius synthesizes deoxyadenosine to cause persistent infection

et al. 2021

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Methicillin-resistant Staphylococcus pseudintermedius (MRSP) is an emerging zoonotic pathogen of canine origin that causes an array of fatal diseases, including bacteremia and endocarditis. Despite large-scale genome sequencing projects have gained substantial insights into the genomic landscape of MRSP, current knowledge on virulence determinants that contribute to S. pseudintermedius pathogenesis during human or canine infection is very limited. Using a panel of genetically engineered MRSP variants and a mouse abscess model, we here identified the major secreted nuclease of S. pseudintermedius designated NucB and adenosine synthase A (AdsA) as two synergistically acting enzymes required for MRSP pathogenesis. Similar to Staphylococcus aureus, S. pseudintermedius requires nuclease secretion along with the activity of AdsA to degrade mammalian DNA for subsequent biosynthesis of cytotoxic deoxyadenosine. In this manner, S. pseudintermedius selectively kills macrophages during abscess formation thereby antagonizing crucial host immune cell responses. Ultimately, bioinformatics analyses revealed that NucB and AdsA are widespread in the global S. pseudintermedius population. Together, these data suggest that S. pseudintermedius deploys the canonical Nuc/AdsA pathway to persist during invasive disease and may aid in the development of new therapeutic strategies to combat infections caused by MRSP.

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Section: Discussionmentioning

confidence: 99%

Methicillin-resistant Staphylococcus pseudintermedius synthesizes deoxyadenosine to cause persistent infection

et al. 2021

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“…Recently, the first case of human infection due to S. delphini has been described (Magleby et al 2019), but virulence factors that might be present were not studied.…”

Section: Human Health Implications Of These Virulence Factorsmentioning

confidence: 99%

Virulence factors in coagulase-positive staphylococci of veterinary interest other than Staphylococcus aureus

González-Martín

Corbera

Suárez‐Bonnet

et al. 2020

Veterinary Quarterly

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Coagulase-positive Staphylococci (CoPS) can exist as commensals in humans, companion and food-producing animals, but can cause severe or even lethal diseases. Exchange of these bacteria between humans and animals has been described. Special attention has been focused on Methicillin-Resistant Staphylococcus aureus, but other CoPS can also represent an important threat. In addition to significant antimicrobial resistance, these bacteria may carry a plethora of virulence factors-molecules that allow bacteria to establish on or within a host and increase their ability to cause disease. These virulence factors have been widely described in S. aureus but information about other species of CoPS is scarce. The aim of this paper is to review the recent literature about the virulence factors of non-aureus CoPS of animal origin. Their possible effects on human health are also described. The role and prevalence of different virulence factors including leukocidins, hemolysins, adhesins, enterotoxins, exfoliative and toxic shock syndrome toxins as well as superantigen-like proteins are addressed. The effect of these virulence factors on human health is also described. The possibility of misdiagnosis of species of CoPS has been demonstrated in human clinical samples. Prevalence of zoonotic infections could be higher than thought and medical laboratories should be aware of these other staphylococcal species. In keeping with the 'One Health' approach to animal and human disease, medical professionals, veterinarians and health workers should be aware of the risks derived from exposure to these bacteria in people in close contact with animals, including pet owners, farmers and veterinarians themselves.

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“…Type strains of S. delphini CCM 4115 T , S. intermedius CCM 5739 T , S. pseudintermedius CCM 7315 T , and S. cornubiensis CCM 8997 T were acquired from the Czech Collection of Microorganisms (Brno, Czech Republic). Reference strains of S. delphini: Nono ( = CCM 4184) /dolphin/, CCM 2618 ( = CCUG 51769) /mink/, P12548, P12549, and P12550 ( = 16-9169-2, 17-7762-1, and 18-3863-5, respectively) /all from minks/ [37], P12456 ( = HT 2030677) /camel/, P12457 and P12458 ( = 8086 and 9106) /both from horses/ [11] and CCM 8998 ( = MI 18-1587) /human/ [36] were described previously and kindly provided by the authors.…”

Section: Bacterial Strains and Their Biochemical Characterizationmentioning

confidence: 99%

“…The taxonomic description of S. delphini, in 1988 [15], was based on two strains isolated from purulent skin lesions of two dolphins. Recently, developments in diagnostics have led to the detection of S. delphini in a broad range of animals [11,12,35] and one reported human case, probably of zoonotic origin [36]. According to the multilocus sequence analysis of the sodA, hsp60, and nuc genes, S. delphini is divided into two phylogenetically distinct clades; group A closely related to the S. delphini type strain, and group B related to the S. pseudintermedius type strain [12].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Staphylococcus intermedius Group Isolates Associated with Animals from Antarctica and Emended Description of Staphylococcus delphini

et al. 2020

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Members of the genus Staphylococcus are widespread in nature and occupy a variety of niches, however, staphylococcal colonization of animals in the Antarctic environment has not been adequately studied. Here, we describe the first isolation and characterization of two Staphylococcus intermedius group (SIG) members, Staphylococcus delphini and Staphylococcus pseudintermedius, in Antarctic wildlife. Staphylococcus delphini were found exclusively in Adélie penguins. The report of S. pseudintermedius from Weddell seals confirmed its occurrence in all families of the suborder Caniformia. Partial RNA polymerase beta-subunit (rpoB) gene sequencing, repetitive PCR fingerprinting with the (GTG)5 primer, and matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry gave consistent identification results and proved to be suitable for identifying SIG members. Comparative genomics of S. delphini isolates revealed variable genomic elements, including new prophages, a novel phage-inducible chromosomal island, and numerous putative virulence factors. Surface and extracellular protein distribution were compared between genomes and showed strain-specific profiles. The pathogenic potential of S. delphini was enhanced by a novel type of exfoliative toxin, trypsin-like serine protease cluster, and enterotoxin C. Detailed analysis of phenotypic characteristics performed on six Antarctic isolates of S. delphini and eight reference strains from different animal sources enabled us to emend the species description of S. delphini.

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First reported human isolation of Staphylococcus delphini

Cited by 23 publications

References 23 publications

Methicillin-resistant Staphylococcus pseudintermedius synthesizes deoxyadenosine to cause persistent infection

Methicillin-resistant Staphylococcus pseudintermedius synthesizes deoxyadenosine to cause persistent infection

Virulence factors in coagulase-positive staphylococci of veterinary interest other than Staphylococcus aureus

Characterization of Staphylococcus intermedius Group Isolates Associated with Animals from Antarctica and Emended Description of Staphylococcus delphini

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