First Reported Case of Unilateral Graves' Disease in the Left Lobe of a Bilobar Thyroid Gland

Chen, Louis C.; Green, Jennifer B.

doi:10.1089/thy.2010.0343

Cited by 9 publications

(10 citation statements)

References 11 publications

(9 reference statements)

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“…Previous reports have described cases of unilateral Graves' disease with increased iodine uptake in one lobe and normal uptake on the other side 3 . However, our case displayed different degrees of increased iodine uptake in both lobes.…”

Section: Figcontrasting

confidence: 59%

A case of “asymmetrical” Graves’ disease with lateral radioisotope uptake

Konda

Minamitani

Takatani

et al. 2021

Pediatrics International

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World Health Organization. Coronavirus disease (COVID-19) pandemic. who.int [homepage on the internet] Gen eve: World Health Organization. [Cited 2020 Oct 21]. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019 2 Ministry of Health, Labor and Welfare. Clinical Management of Patients with COVID-19 A guide for front-line healthcare workers Version 3. mhlw.go.jp [homepage on the internet]. Tokyo: Ministry of Health, Labor and Welfare. [Cited 2020 Oct 5]. Available from: https://www.mhlw.go.jp/content/ 000668291.pdf 3 Leber AL, Everhart K, Daly JA et al. Multicenter evaluation of BioFire FilmArray respiratory panel 2 for detection of viruses and bacteria in nasopharyngeal swab samples.

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Section: Figcontrasting

confidence: 59%

A case of “asymmetrical” Graves’ disease with lateral radioisotope uptake

Konda

Minamitani

Takatani

et al. 2021

Pediatrics International

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“…GD usually presents as a diffuse hyperthyroid goitre involving both lobes of the thyroid. There are also reports of a rare form of GD termed ‘unilateral GD’, in which iodine uptake is normal in one lobe and elevated in the other lobe 8–11. Interestingly, most unilateral GD cases involve the right lobe 11.…”

Section: Discussionmentioning

confidence: 99%

“…There are also reports of a rare form of GD termed ‘unilateral GD’, in which iodine uptake is normal in one lobe and elevated in the other lobe 8–11. Interestingly, most unilateral GD cases involve the right lobe 11. As thyroid hemiagenesis mostly involves the left lobe, it is possible that the right lobe has vascular or developmental advantages over the left lobe in terms of both organogenesis and functional status.…”

Section: Discussionmentioning

confidence: 99%

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Asymmetrical Graves’ disease in children: potential usefulness of potassium iodide monotherapy

et al. 2022

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A male junior high school student presented with failure to gain weight and acceleration of growth for 2 years. Free triiodothyronine and free thyroxine levels were elevated, and the thyroid-stimulating hormone (TSH) level was suppressed. TSH receptor antibody (TRAb) and thyroid-stimulating antibody were negative. On I-123 thyroid scintigraphy, iodine uptake was most pronounced in the upper pole of the right lobe. The patient was initially diagnosed with asymmetrical TRAb-negative Graves’ disease (GD). His thyroid hormone level normalised with potassium iodide (KI) alone, and he became TRAb-positive 4 months after the initiation of KI therapy. This case demonstrates a rare presentation of GD that was initially TRAb-negative, which had asymmetrical iodine uptake on a thyroid scan and was confirmed to be TRAb positivity during the follow-up. KI monotherapy could be one of the effective treatment options for GD that is initially TRAb-negative.

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“…We read with interest the article, “Unilateral Graves' disease: The lesser known” by Manthri et al . [1] We congratulate the authors on their new entity of unilateral Graves' disease[2] and also the possible explanations for unilateral Graves' disease. The knifehappy surgeons shall be happy that if surgery needed in these patients of unilateral Graves' disease, might be a hemithyroidectomy rather than total thyroidectomy, thereby preventing the complications of permanent hypoparathyroidism, which is more common with surgery for Graves' disease.…”

mentioning

confidence: 99%