First reported case of Alcaligenes faecalis isolated from bronchoalveolar lavage in a patient with dengue hemorrhagic fever

Agarwal, Arun; Sharma, Samiksha; Bhargava, Vivek; Bhargava, Vibha; Agarwal, Mamta; Airun, Mala

doi:10.4103/2320-8775.177512

Cited by 12 publications

(29 citation statements)

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“…Colistin and meropenem were given, but the patient later succumbed to his illness. 20 In our Case 7 and Case 8, the antibiotic sensitivity test was the same as in the cases of Agarwal and Junejo. In 2019,…”

Section: Resultsmentioning

confidence: 88%

“…One case was a cured foot ulcer, and the other case was a recurrence of foot ulcer. 17 19,20,25 In 2010, Junejo reported on a 73-year-old male with A. faecalis pneumonia. The sensitivity analysis of sputum culture showed that the isolated A. faecalis was resistant to anti-pseudomonas penicillins, carbapenems, aminoglycosides, and quinolones.…”

Section: Resultsmentioning

confidence: 99%

“…[10][11][12] A. faecalis has been associated with endocarditis, bacteremia, meningitis, endophthalmitis, skin and soft tissue infection, urinary tract infection, otitis media, peritonitis, and pneumonia. [13][14][15][16][17][18][19][20] We here report a series of patients with diabetic foot ulcer with A. faecalis infection, in order to improve the clinical care of such patients.…”

Section: Textmentioning

confidence: 99%

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Diabetic Foot Ulcer with Alcaligenes Faecalis Infection

Huang¹

2020

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Background: Diabetic foot ulcers are an increasingly common complex problem and are associated with a very considerable health care burden. Diabetic foot ulcer with Alcaligenes faecalis infection is rarely reported in the literature. We report a case series of diabetic foot ulcer with Alcaligenes faecalis infection treated at our facility. Methods: We conducted a retrospective analysis of all patients with diabetic foot ulcer with Alcaligenes faecalis infection seen from January 2014 to April 2019. We analyzed the clinical characteristics, ulcer lesion classification, comorbidities, prior intravenous antibiotic use within three months, wound culture, antibiotics sensitivity test, and clinical outcomes of these patients. Results: Eight cases of diabetic foot ulcer with Alcaligenes faecalis infection were seen in five males and three females. The mean age was 54.6 years. All patients had other comorbidities, and all ulcer lesions were of chronic duration ( more than 14 days ). All wound cultures revealed polymicrobial infection, with two cases of diabetic foot with extensive-drug resistant Alcaligenes faecalis infection found in 2019. All patients needed intravenous antibiotic therapy and surgical interventions for the chronic ulcer lesion. The wound failed to heal in three patients. Conclusions: All diabetic foot ulcers with Alcaligenes faecalis infection were of chronic duration ( more than 14 days ) and had polymicrobial infection. Extensive-drug resistant Alcaligenes faecalis emerged in 2019. Definitive antibiotic therapy is necessary for all infected wounds and should be based on both the culture results and susceptibility data. All patients will need appropriate wound care, and most will need rapid surgical intervention for an optimal outcome.

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Section: Resultsmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 99%

Section: Textmentioning

confidence: 99%

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Diabetic Foot Ulcer with Alcaligenes Faecalis Infection

Huang¹

2020

Preprint

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“…If the A. faecalis organism is an ESBL strain, carbapenem is an appropriate antibiotic. Four articles mentioned that A. faecalis susceptibility to colistin [8,19,22,23]. We do not have data regarding A. faecalis susceptibility to colistin in this study.…”

Section: Discussion and Literature Reviewmentioning

confidence: 86%

Extensively drug-resistant Alcaligenes faecalis infection

Huang

2020

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Background: Alcaligenes faecalis is usually opportunistic infection in humans. Alcaligenes faecalis infection is often challenging to treat due to its increased resistance to many antibiotics. The results from a clinical study of Alcaligenes faecalis infection may help improve patients’ clinical care. Methods: We conducted a retrospective analysis of all patients presenting with Alcaligenes faecalis infection from January 2014 through December 2019. The medical records of all patients were reviewed for demographic information, clinical symptoms and signs, comorbidities, use of intravenous antibiotics within the past 3 months, bacterial culture, antibiotics sensitivity test, and clinical outcomes. Results: Sixty-one cases of Alcaligenes faecalis infection were seen during the study period, including 25 cases of cystitis, 9 cases of diabetic foot ulcer with infection, 8 cases of pneumonia, 7 cases of acute pyelonephritis, 3 cases of bacteremia, 9 cases of infection at specific sites. Thirty-seven patients (60.7%) had a history of receiving intravenous antibiotics within 3 months of the diagnosis. Fifty-one (83.6%) cases were mixed with other bacterial infections. Extensively drug-resistant infections have been reported since 2018. The best sensitivity rate to A. faecalis was 66.7% for three antibiotics (imipenem, meropenem, and ceftazidime) in 2019. Two antibiotics (ciprofloxacin and piperacillin/tazobactam) sensitivity rates to A. faecalis were less than 50%. Conclusions: The most frequent Alcaligenes faecalis infection sites were in the bloodstream, urinary tract, skin and soft tissue, and middle ear. Alcaligenes faecalis showed markedly decreased sensitivity to commonly used antibiotics and, more recently, extensively drug-resistant Alcaligenes faecalis infections have emerged.

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“…Further studies in a larger sample size are needed for clarification. In India, A. faecalis was recovered from the bronchoalveolar lavage of a hemorrhagic patient with dengue fever and acute respiratory distress syndrome (15). This is probably the first description of bacterial coinfection with this microorganism in a patient with dengue fever.…”

Section: Discussionmentioning

confidence: 87%

First Report of Extended-Spectrum β-Lactamases TEM-116 and OXA-10 in Clinical Isolates of <i>Alcaligenes</i> Species from Kuala Lumpur, Malaysia

2019

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Alcaligenes faecalis, an emerging potential pathogen, is commonly found in soil, water, and hospital environments. It is usually a harmless saprophyte in the microbiota of the human gut but occasionally may give rise to infections especially in immunocompromised hosts. There are reports of A. faecalis infections in patients with acute or chronic otitis media (1), urinary tract infections (UTI) (1,2), wounds (3), skin and soft tissue infections (4), endophthalmitis (5), pancreatic necrosis, and abscess (6). These are usually opportunistic infections and are often linked to contamination of hospital equipment, such as nebulizers and respirators, or fluids used for lavage (2). Filipe and coworkers (7) reported in Angola the isolation of A. faecalis from patients with chronic suppurative otitis media due to the use of bird droppings as a traditional remedy to prevent ear discharge. A. faecalis infection is often difficult to treat due to increased resistance to many antimicrobials, such as β-lactams, aminoglycosides, and quinolones. Previous studies have revealed the presence of extended-spectrum β-lactamase (ESBL)-producing A. faecalis in clinical samples. ESBLs are a group of enzymes capable of breaking down various β-lactam antibiotics. ESBL types PER-1 and TEM-21 have been detected in urinary samples from intensive care patients in Northern Italy

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First reported case of Alcaligenes faecalis isolated from bronchoalveolar lavage in a patient with dengue hemorrhagic fever

Cited by 12 publications

References 0 publications

Diabetic Foot Ulcer with Alcaligenes Faecalis Infection

Diabetic Foot Ulcer with Alcaligenes Faecalis Infection

Extensively drug-resistant Alcaligenes faecalis infection

First Report of Extended-Spectrum β-Lactamases TEM-116 and OXA-10 in Clinical Isolates of <i>Alcaligenes</i> Species from Kuala Lumpur, Malaysia

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