First Report on<i>Toxoplasma gondii</i>Infection in Bosnia and Herzegovina: Study in Blood Donors

Bobić, Branko; Milosavić, Milanka; Guzijan, Gordana; Djurković–Djaković, Olgica

doi:10.1089/vbz.2016.2028

Cited by 9 publications

(10 citation statements)

References 6 publications

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“…In accordance with previous studies conducted on blood donors [ 19 , 22 ], we have also found that the prevalence increases with age, obviously as a result of the cumulative effect of exposure to the parasite over the years. This increase in the infection prevalence is linear, but, unlike the Bosnia and Herzegovina study [ 19 ], in this study, it was detected in both genders, ranging from 8.7% in the youngest age group (18–29 years) to 39.6% in the oldest (>60 years). For the first time in Serbia, we analyzed the prevalence of T. gondii infection in healthy adult males and showed it has matched or surpassed the prevalence in female donors of the same age, albeit not significantly.…”

Section: Discussionsupporting

confidence: 92%

“…According to worldwide data, one third of them (33%) may be considered to be chronically infected with T. gondii [ 17 ], but the prevalence of infection varies greatly among countries. However, the overall prevalence of toxoplasmosis of 20.5% detected in this study is much lower than that reported among blood donors in the neighboring countries—Croatia (47.8% and 53.8%) [ 18 ] and Bosnia and Herzegovina (30.6%) [ 19 ]—in the past decade. The diagnostic algorithm for toxoplasmosis and methodology applied in our study is widely used in Reference Laboratories for Toxoplasmosis throughout Europe.…”

Section: Discussioncontrasting

confidence: 74%

“…The possibility of methodological bias in our study is bypassed by performing two methodologically different tests for specific IgG—one based on direct agglutination (HSDA) and one ELISA-based (VIDAS Toxo IgG II). More likely, the differences in prevalence between our and the studies performed in these neighboring countries are due to the differences in the size of the study samples and the fact that they were performed more than 12 and 6 years ago, respectively [ 18 , 19 ]. Nowadays, the results in these countries would probably also present a declining prevalence.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiology of Toxoplasmosis in SERBIA: A Cross-Sectional Study on Blood Donors

et al. 2022

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Toxoplasmosis is a globally distributed parasitic zoonosis, affecting approximately one third of the human population. Epidemiological studies on toxoplasmosis conducted in Serbia so far have been focused on women of childbearing age, without a clear insight into the prevalence in the general population. We conducted a cross-sectional study in a representative sample of the healthy adult population consisting of 1095 blood donors of both genders to establish the prevalence and risk factors for Toxoplasma gondii infection. Data on the demographic and clinical characteristics of all study participants, as well as on their lifestyle habits, were collected by means of a questionnaire. The overall prevalence of infection was 20.5% (224/1095) and the avidity of the specific IgG antibodies detected was high in a vast majority of the seropositive donors (98.2%). Interestingly, the remaining 1.8% of the specific IgG positive samples were of borderline avidity (4/224), in complete absence of specific IgM. The multivariate logistic regression analysis showed that independent risk factors included age (from OR (95% CI) 1.9 (1.13–3.28) in the 30–39 age group, to 6.8 (3.27–14.24) in the age group of >60 years), suburban living (OR (95% CI) 2.2 (1.43–3.34)) and contact with soil (OR (95% CI) 1.4 (1.01–1.94)). This first large-scale study on toxoplasmosis in the general population in Serbia shows the lowest prevalence ever reported in this country. Moreover, the novel perspective on risk factors provides an updated basis for future prevention programs.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

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Epidemiology of Toxoplasmosis in SERBIA: A Cross-Sectional Study on Blood Donors

et al. 2022

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“…23 Infection with T. gondii has been detected in blood donors. [24][25][26] However, the extent of the association between blood transfusion and infection with T. gondii remains unclear. To the best of our knowledge, no case-control study has been performed to investigate this issue.…”

Section: Introductionmentioning

confidence: 99%

Association between Toxoplasma gondii infection and history of blood transfusion: a case-control seroprevalence study

et al. 2018

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ObjectivesThis study was performed to determine the association between seropositivity to Toxoplasma gondii and a history of blood transfusion.MethodsPatients who had undergone blood transfusion (n = 410) and age- and sex-matched controls who had not undergone blood transfusion (n = 1230) were examined for anti-T. gondii IgG and IgM antibodies using enzyme-linked immunoassays.ResultsAnti-T. gondii IgG antibodies were detected in 57 (13.9%) patients and in 129 (10.5%) controls with a borderline difference [odds ratio (OR) = 1.37, 95% confidence interval (CI) = 0.98–1.92]. High anti-T. gondii IgG antibody levels (>150 IU/mL) were found in 27 (47.4%) of the 57 anti-T. gondii IgG-positive patients and in 37 (28.7%) of the 129 anti-T. gondii IgG positive controls with a significant difference (OR = 2.23, 95% CI = 1.17–4.26). Anti-T. gondii IgM antibodies were found in 13 (22.8%) of the 57 seropositive patients and in 37 (28.7%) of the 129 seropositive controls, but the difference was not significant (OR = 0.73, 95% CI = 0.35–1.52). Seroprevalence was significantly higher in patients aged >50 years than in controls of the same age and in female patients than in female controls.ConclusionsThese findings indicate that a history of blood transfusion is a risk factor for T. gondii infection.

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“…Toxoplasma parasitemia could be diagnosed using blood smears examination and by polymerase chain reaction . T gondii infection has been distinguished in blood donors and previous studies reported a correlation between Toxoplasma infection and blood transfusion and recommended molecular screening for Toxoplasma infection before blood transfusion especially in the immunocompromised patients …”

Section: Introductionmentioning

confidence: 99%

Serological and molecular screening of umbilical cord blood for Toxoplasma gondii infection

Botein

Darwish

El-Tantawy

et al. 2019

Transplant Infectious Dis

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Background: Human umbilical cord blood has proven to be a successful alternate source of hematopoietic stem cells for pediatric patients with major hematologic disorders. Toxoplasma gondii is a global opportunistic protozoan which cause fatal complications in immunocompromised individuals. Aim:Our goal is to study the prevalence of toxoplasmosis in umbilical cord blood (UCB) and to assess the sensitivity of ELISA and PCR for Toxoplasma infection screening. Material and Methods:One hundred cord blood samples were collected immediately after delivery. Anti-Toxoplasma IgG and IgM antibodies were determined using ELISA method; Toxoplasma DNA was detected using nested PCR technique. Total nucleated cells (TNC) and HB were also determined. Demographic data and risk factors data related to the transmission of toxoplasmosis, were collected from mothers. Results:Among 100 cord blood samples, 36 (36%) were positive for anti-Toxoplasma IgG antibodies and 6 (6%) were positive for anti-Toxoplasma IgM antibodies. The nested PCR showed 11 (11%) samples containing Toxoplasma DNA from which, 6 (55%) samples were IgM positive. There was no significant association between the risk of Toxoplasma transmission and cord blood positivity for toxoplasmosis. Conclusion:Owing to the prevalence of toxoplasmosis, its rapid progression and its fatal outcome in immunocompromised patients, cord blood screening for toxoplasmosis with nested PCR should be incorporated into cord blood bank screening protocols. K E Y W O R D Sbank, cord blood, diagnosis, screening, Toxoplasma

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First Report onToxoplasma gondiiInfection in Bosnia and Herzegovina: Study in Blood Donors

Abstract: This study provided the first data on the prevalence of Toxoplasma infection in B&H, as well as insight into the demographic risk factors as a basis for a future prevention program for Toxoplasma infection.

Cited by 9 publications

References 6 publications

Epidemiology of Toxoplasmosis in SERBIA: A Cross-Sectional Study on Blood Donors

Epidemiology of Toxoplasmosis in SERBIA: A Cross-Sectional Study on Blood Donors

Association between Toxoplasma gondii infection and history of blood transfusion: a case-control seroprevalence study

Serological and molecular screening of umbilical cord blood for Toxoplasma gondii infection

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