First report of Wohlfahrtiimonas chitiniclastica from soft tissue and bone infection at an unusually high northern latitude

Kõljalg, Siiri; Telling, Kaidi; Huik, Kristi; Murruste, Marko; Saarevet, Virve; Pauskar, Merit; Lutsar, Irja

doi:10.1007/s12223-014-0355-x

Cited by 29 publications

(44 citation statements)

References 14 publications

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“…Many of the patients affected are homeless. Maggots have been identified in some, but not all, of the cases described (8)(9)(10)(11). In one previously described case, a patient from Estonia presented similarly to the patient described here (10).…”

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confidence: 63%

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First Report of Wohlfahrtiimonaschitiniclastica Isolation from a Patient with Cellulitis in the United States

et al. 2015

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We report the first documented isolation of Wohlfahrtiimonas chitiniclastica from a human in the United States. Initially misidentified as Acinetobacter lwoffii by Vitek-2, the isolate was subsequently identified as W. chitiniclastica by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and 16S rRNA gene sequencing. While the clinical significance of the isolate in this case is unclear, it highlights the superior performance of MALDI-TOF MS for bacterial identification. CASE REPORTA 26-year-old morbidly obese male courier worker was admitted with worsening right leg swelling and draining ulcers. He had developed lymphedema of the right leg during the preceding year after undergoing surgical correction of a right lower extremity varus deformity. A few weeks prior to the current admission, he had noticed right leg ulcers draining yellowish green serosanguineous fluid. On admission, he was afebrile and his white blood cell count was 11,100/l. He was found to have right lower extremity cellulitis.A swab was collected from the right leg and sent to the microbiology laboratory for wound cultures. The sample was inoculated onto blood, chocolate, and MacConkey agars and incubated under aerobic conditions at 37°C. Gram staining revealed many Gram-negative bacilli and moderate Gram-positive cocci. Four different organisms were isolated from the swab after growth. Microbial identification of each isolate was performed by using routine biochemical tests, including automated identification by the Vitek 2 system (bioMérieux, Marcy l'Etoile, France). The organisms were identified as Proteus vulgaris, Klebsiella pneumoniae, Acinetobacter lwoffii, and Staphylococcus aureus. The isolates were subsequently analyzed in triplicate by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) (RUO version 3.1, Bruker Biotyper; Bruker Daltonics, Bremen, Germany). Of note, the isolate identified as A. lwoffii by the Vitek 2 system was identified by MALDI-TOF MS as Wohlfahrtiimonas chitiniclastica, with identification log (score) values of 2.253, 2.296, and 2.229. Log (score)

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confidence: 63%

“…Maggots have been identified in some, but not all, of the cases described (8)(9)(10)(11). In one previously described case, a patient from Estonia presented similarly to the patient described here (10). Other reported cases that have been described include septicemia and skin and soft tissue infections (8)(9)(10)(11).…”

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confidence: 64%

First Report of Wohlfahrtiimonaschitiniclastica Isolation from a Patient with Cellulitis in the United States

et al. 2015

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“…For instance, as described in case 3, the common green bottle fly Lucilia sericata was identified as source of a W. chitiniclastica infection [12]. Furthermore, W. chitiniclastica could be isolated from the flies Chrysomya megacephala and Musca domestica [7,23]. Based on the current literature and our own experience biochemical approaches such as API (Analyical Profile Index, bioMérieux, Germany) or VITEK 2 (bioMérieux) to identify W. chitiniclastica lead to wrong and misleading results.…”

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confidence: 99%

Wohlfahrtiimonas chitiniclastica: current insights into an emerging human pathogen

et al. 2017

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Since the first description of Wohlfahrtiimonas chitiniclastica in 2008, a number of well described case reports demonstrating its pathogenic role in humans have been published. Infections may be closely linked to flies, such as Wohlfahrtia magnifica, Lucilia sericata, Chrysomya megacephala or Musca domestica. These insects are potent vectors for the distribution of W. chitiniclastica causing local or systemic infections originating from wounds infested with fly larvae. However, other potential sources of transmission of W. chitiniclastica have been described such as soil or chicken meat. Infections in humans reported to date comprise wound infections, cellulitis, osteomyelitis and sepsis. This review summarizes all the literature available up to now and gives the current knowledge about this emerging human pathogen. Additionally, four patients with proven W. chitiniclastica infections treated at Dresden University Hospital between 2013 and 2015, are included. Special focus was placed on microbiological identification and antibiotic susceptibility testing of the pathogen.

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“…A skin and soft tissue infection was reported in a child with orofacial gangrene (noma) in Niger ( 6 ), and an osteomyelitis case was reported in India ( 7 ). The northernmost region from which a case has been reported is Estonia, where a 64-year-old man with chronic foot gangrene was coinfected with W. chitiniclastica and Myroides odoratimimus ( 8 ). Cases from the United States include septicemia in a deer in Michigan ( 9 ) and a leg wound infection in a 26-year-old man in New York ( 10 ).…”

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Wohlfahrtiimonas chitiniclasticaInfections in 2 Elderly Patients, Hawaii, USA

Nogi¹,

Bankowski²,

Pien³

2016

Emerg. Infect. Dis.

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First report of Wohlfahrtiimonas chitiniclastica from soft tissue and bone infection at an unusually high northern latitude

Cited by 29 publications

References 14 publications

First Report of Wohlfahrtiimonaschitiniclastica Isolation from a Patient with Cellulitis in the United States

First Report of Wohlfahrtiimonaschitiniclastica Isolation from a Patient with Cellulitis in the United States

Wohlfahrtiimonas chitiniclastica: current insights into an emerging human pathogen

Wohlfahrtiimonas chitiniclasticaInfections in 2 Elderly Patients, Hawaii, USA

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