First Report of the Protective Effects of Remote Per- and Postconditioning on Ischemia/Reperfusion-Induced Renal Injury

Kadkhodaee, Mehri; Seifi, Behjat; Najafi, Atabak; Sedaghat, Zahra

doi:10.1097/tp.0b013e31823411f8

Cited by 29 publications

(32 citation statements)

References 4 publications

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“…This is in accordance with our previous fi nding, which have been recently published (7). After 24 hours of renal reperfusion, plasma levels of ALT (142.…”

Section: Effect Of Rpec On the Liver Functional Indicessupporting

confidence: 81%

Hepatoprotective effects of remote perconditioning during renal ischemia

Sedaghat¹,

Kadkhodaee²,

Seifi³

et al. 2014

BLL

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Abstract:Background: Novel treatment strategies are required to reduce the development of hepatic injury during surgical procedure in which renal ischemia/reperfusion (IR) is inevitable. Remote perconditioning (rPeC) has been proved to reduce the extent of kidney damages induced by renal IR injury. The aim of this study was to determine the protective effect of rPeC against hepatic injury caused by renal ischemia. Methods: Male rats were subjected to the right nephrectomy and randomized as: sham, no additional intervention; IR, 45 min of left renal pedicle occlusion; rPeC, four cycles of 5-min limb IR administered at the beginning of renal ischemia. After 24-h of reperfusion, the plasma and tissue samples were taken. Results: A signifi cant improvement in hepatic functional injury and oxidative damages were observed in the rPeC group compared to the IR group. However, histological evaluation and plasma levels of TNF-α revealed no signifi cant difference among groups. Conclusions: It is concluded that rPeC exerted protective effects on renal IR-induced hepatic injury as a remote organ. The protection may be a consequence of the reduction in oxidative stress in the liver. This simple approach may be a promising strategy against IR-induced remote organ damages in the clinical practice (Fig. 4

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“…This is in accordance with our previous fi nding, which have been recently published (7). After 24 hours of renal reperfusion, plasma levels of ALT (142.…”

Section: Effect Of Rpec On the Liver Functional Indicessupporting

confidence: 81%

Hepatoprotective effects of remote perconditioning during renal ischemia

Sedaghat¹,

Kadkhodaee²,

Seifi³

et al. 2014

BLL

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“…We have recently demonstrated the protective effect of remote PoC in a renal IRI model. 5 However, postconditioning has also limited clinical applicability and is mostly applicable to patients undergoing manual reperfusion. Some detrimental effects of AKI begin during ischemia and before reperfusion which may result in the activation of programmed cell death during the reperfusion phase.…”

Section: Introductionmentioning

confidence: 99%

Hind limb perconditioning renoprotection by modulation of inflammatory cytokines after renal ischemia/reperfusion

et al. 2016

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Purpose Renal ischemia/reperfusion (I/R) injury is a common clinical problem associated with significant mortality and morbidity. One newly described strategy to reduce this damage is remote perconditioning (RPEC), in which short-time ischemia of a limb during renal ischemia reduces the I/ R-induced kidney injury. This study aimed to assess whether RPEC confer protection through changes in pro-inflammatory mediators. Methods Rats were subjected to right nephrectomy and randomized into: sham (no intervention), I/R (subjected to 45-min left renal ischemia) and RPEC group (subjected to four cycles of 5-min I/R of the femoral artery administered during renal ischemia). After 24-h, blood, urine, and kidney samples were collected. Biochemical indicators of renal dysfunction were measured in the cases of Neutrophil gelatinase-associated lipocalin (NGAL), and N-acetyl-B-diglucosaminidase (NAG) activity. Inflammatory cytokines [interleukin (IL)-6 and tumor necrosis factor-alpha, TNF-a] expression in the renal tissues as well as Periodic acid-Schiff stained histological sections were evaluated. Results I/R resulted in renal dysfunction, as evidenced by higher renal NGAL expression and urinary NAG activities. This was accompanied by increased TNF-a and IL-6 expressions as well as histological changes in this group. However, RPEC improved renal histology and function compared with the I/R group. Furthermore, the RPEC group showed decreases in TNF-a and IL-6 expression. Conclusions These results suggest that RPEC reduces the dysfunction and injury associated with I/R of the kidney. This technique reduced the proinflammatory cytokine in the kidney. RPEC could be a promising strategy against I/R-induced acute kidney injury partly by down-regulation of inflammatory mediators. ARTICLE HISTORY

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“…Kadkhodaee et al [19 ]reported a beneficial effect of rIPerC on renal IRI in a rat model, applying a protocol of 4 × 5 + 5 min of IR by clamping the left femoral artery, while the renal artery was clamped for 45 min. In 2010, it was reported by Bøtker et al [20 ]that rIPerC applied to the arm prior to percutaneous coronary intervention increased myocardial salvage in patients with myocardial infarction.…”

Section: The Evolving Concept Of Icmentioning

confidence: 99%

Molecular Mechanisms of Renal Ischemic Conditioning Strategies

et al. 2015

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Ischemia-reperfusion injury is the leading cause of acute kidney injury in a variety of clinical settings such as renal transplantation and hypovolemic and/or septic shock. Strategies to reduce ischemia-reperfusion injury are obviously clinically relevant. Ischemic conditioning is an inherent part of the renal defense mechanism against ischemia and can be triggered by short periods of intermittent ischemia and reperfusion. Understanding the signaling transduction pathways of renal ischemic conditioning can promote further clinical translation and pharmacological advancements in this era. This review summarizes research on the molecular mechanisms underlying both local and remote ischemic pre-, per- and postconditioning of the kidney. The different types of conditioning strategies in the kidney recruit similar powerful pro-survival mechanisms. Likewise, renal ischemic conditioning mobilizes many of the same protective signaling pathways as in other organs, but differences are recognized.

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First Report of the Protective Effects of Remote Per- and Postconditioning on Ischemia/Reperfusion-Induced Renal Injury

Cited by 29 publications

References 4 publications

Hepatoprotective effects of remote perconditioning during renal ischemia

Hepatoprotective effects of remote perconditioning during renal ischemia

Hind limb perconditioning renoprotection by modulation of inflammatory cytokines after renal ischemia/reperfusion

Molecular Mechanisms of Renal Ischemic Conditioning Strategies

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