Small build‐ups composed primarily of micrite and benthic skeletal remains, termed ‘micro‐bioherms’, have been recognized within Silurian strata of eastern and midcontinental United States for well over 75 years; however, previous research has focused nearly entirely on such structures within the upper Wenlock (Homerian) Waldron Shale. An undolomitized section of the lower Wenlock (Sheinwoodian) Massie Formation in Ripley County, southeastern Indiana, was studied to assess the influence of micro‐bioherms on palaeoecological, taphonomical and sedimentological patterns. Increased baffling of fine‐grained material by organisms composing and/or encrusting build‐ups is evidenced by muddy sediment containing pascichnial traces surrounding micro‐bioherms. Pelmatozoan attachment structures densely encrust micro‐bioherms, but are swollen by secondary stereomic overgrowths reflecting some form of antagonistic interaction or investment in strong affixation to elevated substrates. Clusters of bumastine trilobite material occur in ‘pockets’ related to cavities within build‐ups, and otherwise rare spathacalymenid trilobites, often exceptionally preserved, are found in muds in the vicinity of partially buried micro‐bioherms. Coeval sections nearby are nearly unfossiliferous as result of dolomitization, but contain recognizable skeletal material in greatest abundance in micro‐bioherm flank beds. The occurrence of these bodies within the Massie Formation is genetically linked to a major transgressive episode, but also reflects a mid‐Silurian climatic/palaeoceanographic change.