First report of occurrence of choroid plexus papilloma and medulloblastoma in the same patient

Banka, Siddharth; Walsh, Richard; Bründler, Marie Anne

doi:10.1007/s00381-006-0249-6

Cited by 6 publications

(5 citation statements)

References 12 publications

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“…In some cases confrontation was not required as the patient had admitted to fabricating illness [33,34,35,36]. Some authors reported that confrontation was not used for fear of damaging the therapeutic relationship [37, 38].…”

Section: Resultsmentioning

confidence: 99%

Management of Factitious Disorders: A Systematic Review

Eastwood

Bisson

2008

Psychother Psychosom

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Background: The literature regarding the management of factitious disorder (FD) is diverse and generally of case reports or case series. To date there has been no systematic review of the effectiveness of management techniques. Methods: Systematic review of all evidence reporting the management and subsequent outcome in FD. Data were extracted and outcomes were assessed using an adaptation of the Global Improvement Scale. Results were analysed by parametric statistical tests; a meta-analysis was not possible. Results: Thirty-two case reports and 13 case series were eligible for inclusion. Analysis of the case reports found no significant difference in outcomes between confrontational and non-confrontational approaches [t(29) = 0.72, p = 0.48], between treatment with psychotherapy compared to no psychotherapy [t(30) = 0.69, p = 0.48], and when psychiatric medication had been prescribed compared with not [t(30) = 0.35, p = 0.73]. A trend was observed that a longer length of treatment lead to better outcomes, but this was not significant [F(5, 26) = 1.17, p = 0.35]. The consecutive case series demonstrated that many FD sufferers were not engaged in treatment and were lost to follow-up but did not provide any strong evidence regarding the effectiveness of different management approaches. Conclusions: There is an absence of sufficient robust research to determine the effectiveness of any management technique for FD. The establishment of a central reporting register to facilitate the development of evidence-based guidelines is recommended.

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Section: Resultsmentioning

confidence: 99%

Management of Factitious Disorders: A Systematic Review

Eastwood

Bisson

2008

Psychother Psychosom

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“…However other signaling pathways, most notably the Notch pathway, have been implicated in the formation of choroid plexus neoplasias, as Gdf7-Cre driven expression of the activated ligand Notch ICD [10] led to persistent proliferation of hChPe cells and retrovirus-driven expression of the ligand Notch3 [54] resulted in choroid plexus papillomas. As choroid plexus dysfunction is often linked to hydrocephalus [55] , [56] , it is tempting to speculate that a subset of medulloblastoma patients may have defective choroid plexus function [57] and thus, a common pathological pathway and cellular origin of these diseases.…”

Section: Discussionmentioning

confidence: 99%

Widespread Contribution of Gdf7 Lineage to Cerebellar Cell Types and Implications for Hedgehog-Driven Medulloblastoma Formation

et al. 2012

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The roof plate is a specialized embryonic midline tissue of the central nervous system that functions as a signaling center regulating dorsal neural patterning. In the developing hindbrain, roof plate cells express Gdf7 and previous genetic fate mapping studies showed that these cells contribute mostly to non-neural choroid plexus epithelium. We demonstrate here that constitutive activation of the Sonic hedgehog signaling pathway in the Gdf7 lineage invariably leads to medulloblastoma. Lineage tracing analysis reveals that Gdf7-lineage cells not only are a source of choroid plexus epithelial cells, but are also present in the cerebellar rhombic lip and contribute to a subset of cerebellar granule neuron precursors, the presumed cell-of-origin for Sonic hedgehog-driven medulloblastoma. We further show that Gdf7-lineage cells also contribute to multiple neuronal and glial cell types in the cerebellum, including glutamatergic granule neurons, unipolar brush cells, Purkinje neurons, GABAergic interneurons, Bergmann glial cells, and white matter astrocytes. These findings establish hindbrain roof plate as a novel source of diverse neural cell types in the cerebellum that is also susceptible to oncogenic transformation by deregulated Sonic hedgehog signaling.

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“…[5–7] Although café-au-lait lesions occur with variable frequency in a number of disorders, such as neurofibromatosis types 1 (NF1) and 2, Albright syndrome, among others,[27] to the best of our knowledge this phenotype has never been reported before in association with a non-radiation-induced brain CH and medulloblastoma.…”

Section: Introductionmentioning

confidence: 99%

Metachronous occurrence of nonradiation-induced brain cavernous hemangioma and medulloblastoma in a child with neurofibromatosis type I phenotype

et al. 2012

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Cavernous hemangioma (CH) is a sporadic vascular malformation occurring either as an autosomal dominant condition or as a well-known complication of radiation exposure. Medulloblastoma is a primitive neuroectodermal tumor common in children and currently treated with surgical resection, chemotherapy, and radiotherapy. Neurofibromatosis is the most common single-gene disorder of the central nervous system. Posterior fossa malignant tumors in the context of neurofibromatosis type I (NF1) are very infrequent. This is the first documented case of an unusual metachronous occurrence of non-radiation-induced CH and medulloblastoma in a child with NF1 phenotype. We report the case of a 13-month-old boy with café-au-lait skin lesions associated with NF1-like phenotype who underwent surgical resection of a single CH in the temporal lobe due to recurrent seizures. Four years later he presented with signs of raised intracranial pressure associated with a posterior fossa tumor and hydrocephalus, thus requiring gross total resection of the lesion. Histological analysis revealed a medulloblastoma. After being treated with radiotherapy and chemotherapy, he achieved total remission. Six years later a massive recurrence of the tumor was observed and the child eventually died. The interest in this case lies in the rarity of NF1-like phenotype associated with a non-radiation-induced brain CH and medulloblastoma in a child.

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First report of occurrence of choroid plexus papilloma and medulloblastoma in the same patient

Abstract: The authors review literature for incidence and aetiology of the two tumours.

Cited by 6 publications

References 12 publications

Management of Factitious Disorders: A Systematic Review

Management of Factitious Disorders: A Systematic Review

Widespread Contribution of Gdf7 Lineage to Cerebellar Cell Types and Implications for Hedgehog-Driven Medulloblastoma Formation

Metachronous occurrence of nonradiation-induced brain cavernous hemangioma and medulloblastoma in a child with neurofibromatosis type I phenotype

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