First report of naturally infected Sergentomyia minuta with Leishmania major in Tunisia

Jaouadi, Kaouther; Ghawar, Wissem; Salem, Sadok; Gharbi, Mohamed; Bettaieb, Jihéne; Yazidi, Rihab; Harrabi, Mariem; Hamarsheh, Omar; Salah, Afif Ben

doi:10.1186/s13071-015-1269-4

Cited by 32 publications

(25 citation statements)

References 11 publications

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“…S. minuta is recorded in arid region of Tunisia with an annual precipitation between 88 and 157mm (53), also in Portugal with an annual precipitation equal to 730mm (64). In the present study, it prefers regions with an annual precipitation (Bio 12) between: 50-1100mm, and precipitation seasonality (Bio 15) between: 30-100mm (Supporting Information S1).…”

Section: Discussionsupporting

confidence: 52%

Modeling Spatial Distribution of Sergentomyia minuta (Diptera: Psychodidae) and its Potential Implication in Leishmaniasis Transmission in Morocco

Daoudi¹,

Boussaa²,

Boumezzough³

2020

JAD

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Background: Leishmaniases are parasitic diseases caused by Leishmania species and transmitted by the bite of sand flies. The genus Lutzomyia and Phlebotomus of sand flies are known to be the responsible vector for transmitting almost all Leishmania species to humans. The detection of Leishmania DNA in species of the genus Sergentomyia, in different regions, suggests their likely role in Leishmania transmission. Methods: Our objective was to determine the potential geographical distribution of Sergentomyia minuta, the most dominant Sergentomyia species in Morocco, using ecological niche modeling. Results: The results showed the widespread geographical distribution of S. minuta in Morocco, specifically in northern and central Morocco where visceral and cutaneous leishmaniasis foci occur. There were six abiotic factors affecting the distribution of S. minuta whose annual precipitation, precipitation seasonality and precipitation of driest month as the most important ecological variables of the model. Conclusion: A positive statistical correlation between human leishmaniasis cases and S. minuta abundance was noted suggesting the potential involvement of S. minuta in local Leishmania transmission cycles.

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Section: Discussionsupporting

confidence: 52%

Modeling Spatial Distribution of Sergentomyia minuta (Diptera: Psychodidae) and its Potential Implication in Leishmaniasis Transmission in Morocco

Daoudi¹,

Boussaa²,

Boumezzough³

2020

JAD

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“…Nevertheless, some recent investigations in Tunisia and Portugal have reported the detection of L. major and L. infantum DNA in Se. minuta [ 48 , 52 , 53 ] suggesting its potential role in the transmission of mammal-infecting Leishmania . Also, Senghor et al and Berdjane-Brouk et al suggested that Sergentomyia species could be involved in the transmission of L. major and L. infantum in Africa [ 54 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous leishmaniasis in northwestern Saudi Arabia: identification of sand fly fauna and parasites

et al. 2017

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BackgroundCutaneous leishmaniasis (CL) is a vector-borne disease transmitted by the bite of an infected sand fly. This disease is highly prevalent in Saudi Arabia where Leishmania major and L. tropica are the etiological agents. In the region of Hail, northwestern of Saudi Arabia, the incidence is about 183 cases/year. However, the epidemiology of the disease in this area is not well understood. Thus, an epidemiological survey was conducted in 2015–2016 to identify the circulating parasite and the sand fly fauna in the region of Hail. Skin lesion scrapings were collected from suspected patients with CL.MethodsThe diagnosis was made by microscopic examination of Giemsa-stained smear and PCR. The parasite was identified by PCR and sequencing of the single copy putative translation initiation factor alpha subunit gene. Sand fly specimens were collected and identified morphologically. Total DNA was extracted from the abdomen of female specimens and Leishmania DNA was detected by PCR.ResultsAmong the 57 examined patients, 37 were positive for CL. The identification of the parasite has revealed the single species Leishmania major. The 384 sand flies were collected belonged to two genera (Phlebotomus and Sergentomyia), six sub-genera and six species. Phlebotomus papatasi, Ph. kazeruni and Sergentomyia clydei were the dominant species. Leishmania DNA was detected in two females of Ph. papatasi two of Ph. kazeruni and one specimen of Sergentomyia clydei.Conclusions Leishmania major is confirmed to be the etiological agent of cutaneous leishmaniasis in northwestern Saudi Arabia. The molecular detection of Leishmania DNA in Ph. papatasi and Ph. kazeruni supports the potential role of these two species in the transmission of Leishmania. Further epidemiological studies are needed to prove their role and to evaluate the burden of CL in the study region.

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“…However, these efforts should be pursued and completed by abundance studies [69]. Regarding Sergentomyia species, very little is known, nevertheless these species deserve more attention due to their possible association with TOSV transmission [60] and their putative role in Leishmania transmission [70][71][72][73].…”

Section: Sandflies As Tosv Vectorsmentioning

confidence: 99%

Broader Geographical Distribution of Toscana Virus in the Mediterranean Region Suggests the Existence of Larger Varieties of Sand Fly Vectors

et al. 2020

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Toscana virus (TOSV) is endemic in the Mediterranean basin, where it is transmitted by sand flies. TOSV can infect humans and cause febrile illness as well as neuroinvasive infections affecting the central and peripheral nervous systems. Although TOSV is a significant human pathogen, it remains neglected and there are consequently many gaps of knowledge. Recent seroepidemiology studies and case reports showed that TOSV’s geographic distribution is much wider than was assumed a decade ago. The apparent extension of the TOSV circulation area raises the question of the sandfly species that are able to transmit the virus in natural conditions. Phlebotomus (Ph.) perniciosus and Ph. perfiliewi were historically identified as competent species. Recent results suggest that other species of sand flies could be competent for TOSV maintenance and transmission. Here we organize current knowledge in entomology, epidemiology, and virology supporting the possible existence of additional phlebotomine species such as Ph. longicuspis, Ph. sergenti, Ph. tobbi, Ph. neglectus, and Sergentomyia minuta in TOSV maintenance. We also highlight some of the knowledge gaps to be addressed in future studies.

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First report of naturally infected Sergentomyia minuta with Leishmania major in Tunisia

Cited by 32 publications

References 11 publications

Modeling Spatial Distribution of Sergentomyia minuta (Diptera: Psychodidae) and its Potential Implication in Leishmaniasis Transmission in Morocco

Modeling Spatial Distribution of Sergentomyia minuta (Diptera: Psychodidae) and its Potential Implication in Leishmaniasis Transmission in Morocco

Cutaneous leishmaniasis in northwestern Saudi Arabia: identification of sand fly fauna and parasites

Broader Geographical Distribution of Toscana Virus in the Mediterranean Region Suggests the Existence of Larger Varieties of Sand Fly Vectors

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