First Report of KPC-2 and KPC-3-Producing Enterobacteriaceae in Wild Birds in Africa

Yahia, Houssem Ben; Chairat, Sarra; Gharsa, Haythem; Alonso, Carla Andrea; Sallem, Rym Ben; Porres-Osante, Nerea; Hamdi, Nabil; Torres, Carmén; Slama, Karim Ben

doi:10.1007/s00248-019-01375-x

Cited by 25 publications

(21 citation statements)

References 50 publications

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“…However, our results differ significantly from former studies that have reported higher ESBL detection rates in Chile (67/124, 54%) [33], Spain (68/132, 51.5%) [34], Pakistan (26/150, 17.3%) [35] and The Netherlands (51/414, 12.3%) [36], as well as comparatively elevated CPE detection rates in Tunisia (2/150, 1.3%) [12], Algeria (3/32, 9.4%) [37], France (22/158, 13.9%) [38] and Australia (120/504, 23.8%) [39]. This discrepancy could be attributed either to a lower prevalence of such resistant bacteria in the region or to the fact that many prior studies have only been focused on "target" wild bird species, i.e., migratory, omnivorous and aquatic birds.…”

Section: Discussioncontrasting

confidence: 99%

“…Molecular characterization of the ESBL isolates revealed a dominance of bla CTX-M-1 group, which is consistent with the majority of published studies on wild avian species to date [12,32,[46][47][48][49][50][51]. E. coli producing CTX-M group 1 β-lactamases, especially CTX-M-1 and CTX-M-15, has been described as an alarming cause of human infections globally, while variant CTX-M-1 further prevails among food-producing animals [52][53][54].…”

Section: Discussionsupporting

confidence: 87%

“…Notably, we also detected the acquired AmpC gene bla ACT in four of the isolates, but not bla CMY-2 , even though prior studies worldwide as well as in Greece have described the latter as the most dominant plasmid encoded AmpC beta-lactamase gene in Enterobacteriaceae of wild bird origin [55][56][57]. Co-occurrence of bla ACT and bla CTX-M-1 group has previously been reported in an Escherichia fergusonii isolated from a Cattle egret in Tunisia [12].…”

Section: Discussionsupporting

confidence: 42%

“…Subsequently, wild and feral avian species are deemed as a reservoir and vehicle for AMR dissemination [10]. Indeed, several previous studies have identified clinically relevant resistance determinants, such as the ESBL gene bla CTX-M-15 and the carbapenemase gene bla KPC , among Enterobacteriaceae isolated from wild and feral birds [11][12][13]. Of note, some of these isolates additionally belonged to sequence types frequently detected in human and animal clinical cases, underlining their possible interspecies transmission [14].…”

Section: Introductionmentioning

confidence: 99%

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Occurrence and Characteristics of ESBL- and Carbapenemase- Producing Escherichia coli from Wild and Feral Birds in Greece

et al. 2022

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Wild and feral birds are known to be involved in the maintenance and dissemination of clinically-important antimicrobial-resistant pathogens, such as extended-spectrum β-lactamase (ESBL) and carbapenemase-producing Enterobacteriaceae. The aim of our study was to evaluate the presence of ESBL- and carbapenemase-producing Escherichia coli among wild and feral birds from Greece and to describe their antimicrobial resistance characteristics. In this context, fecal samples of 362 birds were collected and cultured. Subsequently, the antimicrobial resistance pheno- and geno-type of all the obtained E. coli isolates were determined. A total of 12 multidrug-resistant (MDR), ESBL-producing E. coli were recovered from eight different wild bird species. Eleven of these isolates carried a blaCTX-M-1 group gene alone or in combination with blaTEM and one carried only blaTEM. AmpC, fluoroquinolone, trimethoprim/sulfamethoxazole, aminoglycoside and macrolide resistance genes were also detected. Additionally, one carbapenemase-producing E. coli was identified, harboring blaNDM along with a combination of additional resistance genes. This report describes the occurrence of ESBL- and carbapenemase-producing E. coli among wild avian species in Greece, emphasizing the importance of incorporating wild birds in the assessment of AMR circulation in non-clinical settings.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 42%

Section: Introductionmentioning

confidence: 99%

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Occurrence and Characteristics of ESBL- and Carbapenemase- Producing Escherichia coli from Wild and Feral Birds in Greece

et al. 2022

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“…E nterobacteriaceae are a large family of gramnegative Bacilli, being Escherichia coli one of the most representative species of this family. These bacteria can be found in many ecosystems (soil, water, vegetation, and is part of the normal intestinal flora of humans and animals) (Ben Yahia et al, 2020). Some E. coli strains have developed mechanisms of pathogenicity; they are considered to be the most important opportunistic pathogens, which means that they can cause human and animal diseases (Ben Said et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Bacteriophages as Antimicrobial Agents? Proteomic Insights on Three Novel Lytic Bacteriophages Infecting ESBL-Producing Escherichia coli

Dkhili

Ribeiro

Ghariani

et al. 2021

OMICS: A Journal of Integrative Biology

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With the emergence of multiresistant bacteria, the use of bacteriophages is gaining renewed interest as potential antimicrobial agents. The aim of this study was to analyze the structure of three lytic bacteriophages infecting Escherichia coli (SD1, SD2, and SD3) using a gel-based proteomics approach and the cellular response of this bacterium to phage SD1 infection at the proteome level. The combination of the results of 1-DE and 2-DE followed by mass spectrometry led to the identification of 3, 14, and 9 structure proteins for SD1, SD2, and SD3 phages, respectively. Different protein profiles with common proteins were noticed. We also analyzed phageinduced effects by comparing samples from infected cells to those of noninfected cells. We verified important changes in E. coli proteins expression during phage SD1 infection, where there was an overexpression of proteins involved in stress response. Our results indicated that viral infection caused bacterial oxidative stress and bacterial cells response to stress was orchestrated by antioxidant defense mechanisms. This article makes an empirical scientific contribution toward the concept of bacteriophages as potential antimicrobial agents. With converging ecological threats in the 21st century, novel approaches to address the innovation gaps in antimicrobial development are more essential than ever. Further research on bacteriophages is called for in this broader context of planetary health and integrative biology.

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KPC-2-producing Pseudomonas aeruginosa isolated from wild animals in Brazil

dos Santos Costa,

dos Santos,

de Souza

et al. 2023

Braz J Microbiol

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First Report of KPC-2 and KPC-3-Producing Enterobacteriaceae in Wild Birds in Africa

Cited by 25 publications

References 50 publications

Occurrence and Characteristics of ESBL- and Carbapenemase- Producing Escherichia coli from Wild and Feral Birds in Greece

Occurrence and Characteristics of ESBL- and Carbapenemase- Producing Escherichia coli from Wild and Feral Birds in Greece

Bacteriophages as Antimicrobial Agents? Proteomic Insights on Three Novel Lytic Bacteriophages Infecting ESBL-Producing Escherichia coli

KPC-2-producing Pseudomonas aeruginosa isolated from wild animals in Brazil

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