First report of invasive pulmonary infection by Didymella microchlamydospora and successful treatment with voriconazole

Salehi, Mohammadreza; Zibafar, Ensieh; Mahmoudi, Shahram; Hashemi, Seyed Hossein; Gatmiri, S.M.; Shoar, Mohsen Gerami; Manshadi, Seyed Ali Dehghan; Jahanbin, Behnaz; Alizadeh, Rafieh; Hosseinpour, Leila; Ardi, Pegah; Ghazvini, Roshanak Daie

doi:10.1016/j.cmi.2018.10.018

Cited by 3 publications

(3 citation statements)

References 4 publications

(6 reference statements)

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“…Among them, Alternaria , Cladosporium , and Penicillium (present in all localities), and Aspergillus , Aureobasidium , Beauveria , Curvularia , Epicoccum , Fusarium, and Trichoderma (present only in Els Pallaresos and Reus) have been previously described as allergenic to humans [ 11 , 16 , 22 , 98 , 99 ]. Within these genera, 64 species have been identified, including Alternaria infectoria , Aureobasidium pullulans , Didymella glomerata , Didymella microchlamydospora , Exophiala xenobiotica , Knufia epidermdis , Neoscytalidium dimidiatum , and Stemphylium vesicarium (all found in Els Pallaresos, Montbrió del Camp and Reus), which are considered opportunistic pathogens for humans ( Table S1 ) [ 27 , 36 , 42 , 100 , 101 , 102 , 103 , 104 ].…”

Section: Discussionmentioning

confidence: 99%

Diversity of Rock-Inhabiting Fungi in Tarragona Province, Spain

Sastoque,

Cano-Lira,

Stchigel

2024

JoF

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Rock-inhabiting fungi (RIF) are usually extremely tolerant or extremophilic, as they can survive on natural and artificial rocks despite being exposed to stressful conditions. RIF have serious negative effects on the appearance and cohesion of rocky substrates, causing the alteration and decomposition of building materials, but also on human and animal health, as they can act as opportunistic pathogens. Their identification is therefore of great importance, especially in urban areas. In the present study, culturing techniques for isolating fungi, and a polyphasic taxonomic approach to their identification, were used to assess the diversity of micromycetes that darken the surfaces of buildings in various villages and cities in Tarragona Province (Spain). Sixty-four species of RIF belonging to forty-one genera were identified, including a new genus (Coccodomyces) and the following six new fungal species: Coccodomyces pleiosporus, Exophiala caementiphila, Exophiala multiformis, Neocatenulostroma spinulosum, Neodevriesia longicatenispora, and Paradevriesia holothallica. Thus, we have established that building materials are ecological niches where a high biodiversity of RIF can develop.

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Section: Discussionmentioning

confidence: 99%

Diversity of Rock-Inhabiting Fungi in Tarragona Province, Spain

Sastoque,

Cano-Lira,

Stchigel

2024

JoF

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“…Didymellaceae is a very diverse family in the Pleosporales order, and most reports highlight the importance of this family as a plant fungus. 27 This family has been reported as a human 28,29 and mammal pathogen 17 and as the second most abundant fungus on the skin of West Highland White Terrier puppies. 30 In the present study, Didymellaceae sp and Pleosporales sp were significantly enriched in group 1, which consisted of dogs with relatively less severe periodontal disease.…”

Section: Discussionmentioning

confidence: 99%

The mycobiome of the oral cavity in healthy dogs and dogs with periodontal disease

Niemiec

Gawor²,

Tang³

et al. 2022

ajvr

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OBJECTIVE To investigate the mycobiome of the oral cavity in healthy dogs and dogs with various stages of periodontal disease. ANIMALS 51 dogs without periodontal disease (n = 12) or with mild (10), moderate (19), or severe (10) periodontal disease. PROCEDURES The whole maxillary arcade of each dog was sampled with a sterile swab, and swabs were submitted for next-generation DNA sequencing targeting the internal transcribed spacer 2 region with a commercial sequencing platform. RESULTS Fungi were detected in all samples, with a total of 320 fungal species from 135 families detected in the data set. No single fungal species was found in all samples. The 3 most frequently found fungal species were Cladosporium sp (46/51 samples), Malassezia restricta (44/51 samples), and Malassezia arunalokei (36/51 samples). Certain fungi, specifically those of the family Didymellaceae, the family Irpicaceae, and the order Pleosporales, were significantly associated with different stages of periodontitis. Mycobial analysis indicated that Cladosporium sp could be considered part of the core oral cavity mycobiome. CONCLUSIONS AND CLINICAL RELEVANCE Results highlighted that fungi are present in the oral cavity of dogs and are characterized by substantial species diversity, with different fungal communities associated with various stages of periodontal disease. The next-generation DNA sequencing used in the present study revealed substantially more species of fungi than previous culture-based studies.

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“…Different therapeutic options have been used in clinical cases, most of which had satisfactory outcomes. In the studies performed by Salehi (2019) [ 17 ], Roehm (2012) [ 18 ], and Errera (2008) [ 7 ], voriconazole and amphotericin B showed the best activity against Phoma isolates. These last findings are similar to those observed for P. pedeiae .…”

Section: Discussionmentioning

confidence: 99%

First report of chronic invasive fungal rhinosinusitis in a patient with ovarian cancer caused by Didymella pedeiae and successful treatment with voriconazole: A case report

Raiesi¹,

Hashemi²,

Getso³

et al. 2021

CMM

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Background and Purpose: Didymella pedeiae is a dematiaceous fungus that belongs to the Coelomycetes class. While species within this class are known to cause human infection, D. pedeiae had previously only been known as phytopathogens and had never been isolated from a human sample. Case report: A 51-year-old Iranian female patient with ovarian cancer was admitted with unilateral lesions in paranasal sinuses and a five-month history of nasal obstruction,headache, postnasal drainage, swelling on the left side of the face, and orbital pain.Paranasal sinus computerized tomography scan revealed a soft tissue mass that filled the left nasal cavity, ethmoid, sphenoid, and frontal sinuses with more involvement in the maxillary and ethmoid sinuses. Antifungal treatment was simultaneously initiated with itraconazole+prednisolone 15 mg/day, and levofloxacin. Due to poor clinical response,IV voriconazole and amphotericin B were added to the treatment as well. The patient recovered completely after 10 weeks of therapy. Conclusion: Here, we report the first case of human D. pedeiae infection in a patientwith ovarian cancer.

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First report of invasive pulmonary infection by Didymella microchlamydospora and successful treatment with voriconazole

Cited by 3 publications

References 4 publications

Diversity of Rock-Inhabiting Fungi in Tarragona Province, Spain

Diversity of Rock-Inhabiting Fungi in Tarragona Province, Spain

The mycobiome of the oral cavity in healthy dogs and dogs with periodontal disease

First report of chronic invasive fungal rhinosinusitis in a patient with ovarian cancer caused by Didymella pedeiae and successful treatment with voriconazole: A case report

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