First Report of <i>Ilyonectria vredehoekensis</i> Causing Rusty Root on American Ginseng in China

Zhang, X.-M.; Xiao, Lu; Jiao, X. L.; Bi, Yang; Gao, Weiwei

doi:10.1094/pdis-01-19-0008-pdn

Cited by 2 publications

(1 citation statement)

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“…Historically, the plant was native to the USA and Canada. Since Wendeng (China) has a comparable latitude and similar climate to the producing areas in the USA, P. quinquefolius has been cultivated in the county in recent decades 4 . The active components of P. quinquefolius are known as ginsenosides.…”

Section: Introductionmentioning

confidence: 99%

LC-MS Analysis of Ginsenosides in Different Parts of Panax quinquefolius and Their Potential for Coronary Disease Improvement

et al. 2023

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Seven main ginsenosides, including ginsenoside Re, ginsenoside Rb1, pseudoginsenoside F11, ginsenoside Rb2, ginsenoside Rb3, ginsenoside Rd and ginsenoside F2, were identified by LC-QTOF MS/MS from root, leaf and flower extracts of Panax quinquefolius. These extracts promoted intersegmental vessel growth in a zebrafish model, indicating their potential cardiovascular health benefits. Network pharmacology analysis was then conducted to reveal the potential mechanisms of ginsenoside activity in the treatment of coronary artery disease. GO and KEGG enrichment analyses elucidated that G protein-coupled receptors played a critical role in VEGF-mediated signal transduction and that the molecular pathways associated with ginsenoside activity are involved in neuroactive ligand-receptor interaction, cholesterol metabolism and the cGMP–PKG signaling pathway, etc. Moreover, VEGF, FGF2, and STAT3 were confirmed as the major targets inducing proliferation of endothelial cells and driving the pro-angiogenic process. Overall, ginsenosides could be potent nutraceutical agents that act to reduce the risks of cardiovascular disease. Our findings will provide a basis to utilize the whole P. quinquefolius plant in drugs and functional foods.

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Section: Introductionmentioning

confidence: 99%