First Report of Human Infection with Haemonchus contortus, Ostertagia ostertagi, and Marshallagia marshalli (Family Trichostrongylidae) in Iran

Ghadirian, E.; Arfaa, F.

doi:10.2307/3278661

Cited by 22 publications

(20 citation statements)

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“…The infection rate of trichostrongylids in caprines is high, and infective larvae may spread to all areas in close proximity to houses, and also through contact with fomites, or nearby where vegetables are cultivated and eaten raw. There is a high potential for active transmission not only of Trichostrongylus spp., as described previously, but also of other animal nematodes in humans, such as Haemonchus and Oesophagostomum, as previously described (GHADIRIAN;ARFAA, 1973;BLOTKAMP et al, 1993). We recommend that these infections be considered an important issue for public health concern in Laos and other Southeast Asian countries.…”

Section: Resultssupporting

confidence: 70%

“…While Trichostrongylus infection in humans has already been reported in this area (SATO et al, 2010, 2011), there are no reports of oesophagostomosis and haemonchosis among humans in Laos. There is a high possibility of infection in Lahanam Village, since the way of infection could be similar for these species, and there are studies showing Haemonchus (GHADIRIAN;ARFAA, 1973) and Oesophagostomum (BLOTKAMP et al, 1993) infection in humans. More studies are required involving DNA confirmation of Strongyloidea eggs found in human faeces, because the severity of the pathogenicity of Haemonchus and Oesophagostomum can be more important than that caused by Trichostrongylus.…”

Section: Resultsmentioning

confidence: 99%

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Nematode infection among ruminants in monsoon climate (Ban-Lahanam, Lao PDR) and its role as food-borne zoonosis

Sato

Chaisiri

et al. 2014

Rev. Bras. Parasitol. Vet.

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Trichostrongylids infection has gained significant public health importance since Trichostrongylus spp. infections have been reported in humans in Lao PDR. In this study, gastrointestinal nematodes were identified and the intensity of infections was determined in goats and cattle, which are animals greatly used for meat production in Lahanam Village, Lao PDR. The total number of goats and bovines was 23 and 29, respectively, pertaining to 32 households surveyed in the area. Feacal samples were randomly collected from 14 goats and 11 bovines. Ninety three percent (13/14) of goats and 36% (3/11) of cattle were infected, with an average of 1,728 and 86 eggs per gram of faeces (EPG), respectively. Coproculture showed Trichostrongylus spp. (goats 16%; bovines 48%), Haemonchus spp. (goats 69%; bovines 37%), Cooperia spp. (bovines 8%) and Oesophagostomum spp. (goats 15%; bovines 6%). After performing the necropsy on an adult goat, Trichuris spp. was also found. We confirmed the presence of Oesophagostomum spp., H. contortus and T. colubriformis by morphology and DNA sequencing analysis of the ITS region of rDNA. Due to interactions between humans and goats in Lahanam Village and high EPG results, the diagnosis of species and the intensity of gastrointestinal nematode infection in these animals are important public-health issues. Other ruminant parasites, such as Oesophagostomum and Haemonchus, found in caprines and bovines, are reported to be causes of zoonosis and their presence in humans should be investigated in future field surveys in this area.

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Section: Resultssupporting

confidence: 70%

Section: Resultsmentioning

confidence: 99%

Nematode infection among ruminants in monsoon climate (Ban-Lahanam, Lao PDR) and its role as food-borne zoonosis

Sato

Chaisiri

et al. 2014

Rev. Bras. Parasitol. Vet.

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“…It is found with a lesser extent in sheep, goats, wild ruminants and horses [1,40]. It was also reported occasionally in humans from Iran and Azerbaidjan [3]. T. circumcincta is the most important species of the genus found in sheep but it occurs in a variety of other ruminants such as goats and camels.…”

Section: Discussionmentioning

confidence: 99%

“…Among the Trichostrongyloidae, Trichostrongylus is the most common genus infecting humans in endemic regions [1]. Other genera of trichostrongyloid nematodes such as Haemonchus contortus, Marshallagia marshalli, Nematodirus abnormalis, Ostertagia ostertagi and O. circumcincta (Teladorsagia circumcincta) have been reported in humans, particularly in Iran and Azerbaidjan, of former Soviet Union [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…O. ostertagi mainly infects cattle, but also sheep, goats and other domestic and wild ruminants [1]. It has been reported from two persons in central part of Iran and one person in Azerbaijan of former Soviet Union [3]. T. circumcincta, which was originally placed in the genus Ostertagia, is a parasitic nematode of gastric glands of the stomach that infects sheep and goats all around the world and leads to weight loss, decreased wool production and death [18].…”

Section: Introductionmentioning

confidence: 99%

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Zoonotic transmission of Teladorsagia circumcincta and Trichostrongylus species in Guilan province, northern Iran: molecular and morphological characterizations

et al. 2020

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Background: Parasitic trichostrongyloid nematodes have a worldwide distribution in ruminants and frequently have been reported from humans in Middle and Far East, particularly in rural communities with poor personal hygiene and close cohabitation with herbivorous animals. Different species of the genus Trichostrongylus are the most common trichostrongyloids in humans in endemic areas. Also, Ostertagia species are gastrointestinal nematodes that mainly infect cattle, sheep and goats and in rare occasion humans. The aim of the present study was to identify the trichostrongyloid nematodes obtained from a familial infection in Guilan province, northern Iran, using morphological and molecular criteria. Methods: After anthelmintic treatment, all fecal materials of the patients were collected up to 48 h and male adult worms were isolated. Morphological identification of the adult worms was performed using valid nematode keys. Genomic DNA was extracted from one male worm of each species. PCR amplification of ITS2-rDNA region was carried out, and products were sequenced. Phylogenetic analysis of the nucleotide sequence data was performed using MEGA 6.0 software. Results: Adult worms expelled from the patients were identified as T. colubriformis, T. vitrinus and Teladorsagia circumcincta based on morphological characteristics of the males. Phylogenetic analysis illustrated that each species obtained in current study was placed together with reference sequences submitted to GenBank database. Conclusions: The finding of current study confirms the zoonotic aspect of Trichostrongylus species and T. circumcincta in inhabitants of Guilan province. The occurrence of natural human infection by T. circumcincta is reported for the first time in Iran and the second time in the world.

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Genetic characterization of selected parasites from people with histories of gastrointestinal disorders using a mutation scanning‐coupled approach

et al. 2013

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A SSCP analysis and targeted sequencing approach was used for the genetic characterization of some major pathogens from a cohort of 227 people with histories of gastrointestinal disorders. Genomic DNAs from fecal samples were subjected to PCR-amplification of regions in the glycoprotein (gp60) or triose phosphate isomerase (tpi) gene, or the second internal transcribed spacer of nuclear ribosomal DNA (ITS-2). Cryptosporidium, Giardia, and strongylid nematodes were detected in 94, 132 and 12 samples. Cryptosporidium hominis subgenotypes IbA10G2, IdA15G1, IgA17, IgA18, and IfA13G1 were identified in 74.6, 16.9, 5.6, 1.4, and 1.4% of 71 samples, respectively. For Cryptosporidium parvum, subgenotypes IIaA17G2R1 (47.6%) and IIaA18G3R1 (23.8%) were identified in 23 samples. Giardia duodenalis assemblage B (78%) was more common than assemblage A (22%). In addition, DNA of the nematodes Ancylostoma ceylanicum (n = 2), Ancylostoma duodenale (4), Necator americanus (5), and Haemonchus contortus (1) was specifically detected. This is the first report of A. ceylanicum in two persons in Australia and, we provide molecular evidence of H. contortus in a child. This SSCP-based approach should provide a useful diagnostic and analytical tool for a wide range of pathogens.

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First Report of Human Infection with Haemonchus contortus, Ostertagia ostertagi, and Marshallagia marshalli (Family Trichostrongylidae) in Iran

Cited by 22 publications

References 0 publications

Nematode infection among ruminants in monsoon climate (Ban-Lahanam, Lao PDR) and its role as food-borne zoonosis

Nematode infection among ruminants in monsoon climate (Ban-Lahanam, Lao PDR) and its role as food-borne zoonosis

Zoonotic transmission of Teladorsagia circumcincta and Trichostrongylus species in Guilan province, northern Iran: molecular and morphological characterizations

Genetic characterization of selected parasites from people with histories of gastrointestinal disorders using a mutation scanning‐coupled approach

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