First report of chronic hepatitis E in renal transplant recipients in Portugal

Breda, Filipe; Cochicho, Joana; Mesquita, João R.; Bento, Ana; Oliveira, Rui Caetano; Louro, Emília; Nascimento, María Säo José; Leitão, Jorge; Gomes, Henrique; Carvalho, Armando

doi:10.3855/jidc.4637

Cited by 8 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…19 It was interesting to find that the seroprevalence in the Portuguese population was substantial (16.3%), comparing with the fairly low number of autochthonous hepatitis E cases that have been reported so far. 8,20 In fact, most cases of HEV genotype 3 are asymptomatic and the symptomatic ones are not usually recognized because the rate of icteric illness is low and severe hepatitis is rare. 3 However, the high circulation of HEV genotype3 in both domestic pigs 6 and wild boar 21 in Portugal can help explain the substantial seroprevalence in the Portuguese population, which has a strong tradition of pork consumption.…”

Section: Discussionmentioning

confidence: 99%

A nationwide serosurvey of hepatitis E virus antibodies in the general population of Portugal

Nascimento

Rodrigues

Teixeira

et al. 2017

European Journal of Public Health

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

A nationwide serosurvey of hepatitis E virus antibodies in the general population of Portugal

Nascimento

Rodrigues

Teixeira

et al. 2017

European Journal of Public Health

View full text Add to dashboard Cite

show abstract

“…Further hospitalized due to a severe acute hepatitis complicated by Guillain-Barré syndrome (L. Santos et al, 2013 ). Also two renal transplant recipients with chronic hepatitis were initially diagnosed with an hepatitis E by the presence of anti-HEV IgM (Breda et al, 2014 ). The screening of 71 archived sera from a Portuguese pediatric cohort (1–13 years old) collected in 1992–1995 found anti-HEV IgG in two children and anti-HEV IgM in one, suggesting that HEV was circulating in the pediatric population of Portugal in the early 1990s (Mesquita et al, 2016b ).…”

Section: Resultsmentioning

confidence: 99%

Hepatitis E Virus in the Iberian Peninsula: A Systematic Review

et al. 2023

Self Cite

View full text Add to dashboard Cite

One of the most frequent causes of acute viral hepatitis is hepatitis E virus (HEV) causing 20 million infections worldwide each year and 44,000 deaths. Studies on HEV in the Iberian Peninsula have been increasing through time with HEV infection being identified in humans and animals. The aim of the present systematic review was to compile and evaluate all the published data on HEV from studies performed in humans, animals and environmental samples in the Iberian Peninsula. The electronic databases Mendeley, PubMed, Scopus, and Web of Science were thoroughly searched, and research published up until February 01, 2023 were included. Resulting in a total of 151 eligible papers by full reading and application of PRISMA exclusion/inclusion criteria. Overall, the present review shows that several HEV genotypes, namely HEV-1, 3, 4, and 6 as well as Rocahepevirus, are circulating in humans, animals, and in the environment in the Iberian Peninsula. HEV-3 was the most common genotype circulating in humans in Portugal and Spain, as expected for developed countries, with HEV-1 only being detected in travelers and emigrants from HEV endemic regions. Spain is the biggest pork producer in Europe and given the high circulation of HEV in pigs, with HEV-3 being primarily associated to zoonotic transmission through consumption of swine meat and meat products, in our opinion, the introduction of an HEV surveillance system in swine and inclusion of HEV in diagnostic routines for acute and chronic human hepatitis would be important. Additionally, we propose that establishing a monitoring mechanism for HEV is crucial in order to gain a comprehensive understanding of the prevalence of this illness and the various strains present in the Iberian Peninsula, as well as their potential impact on public health.

show abstract

“…HEV infection is reported to cause chronic hepatitis in 14.1% of solid organ transplant recipients in France [104]. HEV3 was the predominantly genotype reported in HEV infection in HEV-infected solid-organ transplant recipients in France [105], Portugal [106], and Germany [107]. Although HEV3 is not prevalent in South Africa, a case of HEV3 infection in a renal transplant recipient was reported [108].…”

Section: Kidneymentioning

confidence: 99%

“…Patients with chronic HEV are usually reported with persisting high ALT levels and presence of HEV RNA in their serum [106,109]. However, Gerolami et al (2008) revealed a kidney transplant patient with chronic HEV and normal serum ALT concentrations.…”

Section: Kidneymentioning

confidence: 99%

Implications of Hepatitis E Virus in Blood Transfusions, Hemodialysis, and Solid Organ Transplants

et al. 2020

View full text Add to dashboard Cite

Hepatitis E Virus (HEV) is emerging as the primary cause of acute viral hepatitis in humans. The virus is commonly transmitted by the fecal–oral route via contaminated water in endemic regions or through the consumption of inadequately cooked swine products or game meats in industrialized regions. HEV genotypes 1 and 2 are predominantly associated with waterborne transmission in developing countries, whereas HEV3 and HEV4 are mainly zoonotically transmitted in industrialized countries. Seroprevalence in populations determined by detecting anti-HEV antibodies and serum HEV RNA is commonly used to analyze the presence of HEV. Although HEV RNA-based detection is now standardized, there is a lack of agreement between the assaying methods used for gathering seroprevalence data. Since 2004, HEV has been considered as a transmissible infectious agent through blood transfusion. Recent seroprevalence studies in European countries indicate an underestimated risk for blood transfusion and hence warrant testing the blood supply. HEV infection is usually self-limiting and spontaneously cleared. However, in about 60% of recipients of solid organ transplants, HEV progresses to chronic hepatitis. Immunosuppressive drugs such as tacrolimus are a major cause of chronic hepatitis and reducing its dosage results in viral clearance in about 30% of patients. In hemodialysis patients, the parenteral route is implicated as an important mechanism of transmission. In this review, we explore the clinical and epidemiological characteristics of various HEV genotypes in blood donors, hemodialysis patients, and transplant recipients.

show abstract

First report of chronic hepatitis E in renal transplant recipients in Portugal

Cited by 8 publications

References 15 publications

A nationwide serosurvey of hepatitis E virus antibodies in the general population of Portugal

A nationwide serosurvey of hepatitis E virus antibodies in the general population of Portugal

Hepatitis E Virus in the Iberian Peninsula: A Systematic Review

Implications of Hepatitis E Virus in Blood Transfusions, Hemodialysis, and Solid Organ Transplants

Contact Info

Product

Resources

About