First report of canine African trypanosomosis in the UK

Gow, Adam; Simpson, Juliet K.; Picozzi, Kim

doi:10.1111/j.1748-5827.2007.00423.x

Cited by 26 publications

(28 citation statements)

References 12 publications

(14 reference statements)

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“…According to CON2-LAMP, the majority of dogs were infected with T. congolense. In agreement with previous reports, 3 T. congolense-infected dogs tended to exhibit chronic infections unlike those infected with T. brucei subspecies that showed more acute symptoms. Such chronically infected dogs may act as a source of infection to other domestic animals 4 in tsetseinfested regions.…”

Section: 3supporting

confidence: 82%

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Preliminary Investigation of Trypanosomosis in Exotic Dog Breeds from Zambia's Luangwa and Zambezi Valleys Using LAMP

Namangala

Oparaocha²,

Kajino³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Canine African trypanosomosis (CAT) is rarely reported in the literature. In this preliminary study, we evaluated the performance of loop-mediated isothermal amplification (LAMP) against microscopy to detect CAT in six exotic dog breeds naturally infected with trypanosomes from Zambia's South Luangwa National Park and Chiawa Game Management Area. To our knowledge, this is the first report of CAT in Zambia. The patients exhibited a variety of aspecific clinical signs. The LAMP did not only confirm all six parasitologically positive CAT cases detected passively between April 2010 and January 2012, but was also critical in trypanosome speciation. According to LAMP, the majority of the dogs had monolytic infections with either Trypanosoma congolense or Trypanosoma brucei rhodesiense. The LAMP is thus a potential simple and cost-effective tool for trypanosome diagnosis in endemic regions. The rare report of zoonotic trypanosomes in dogs in Zambia has public health implications and justifies further investigations of CAT.

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Section: 3supporting

confidence: 82%

“…3,5 This communication evaluates the performance of loop-mediated isothermal amplification (LAMP) in detecting CAT from six exotic dogs naturally infected with trypanosomes from Zambia's South Luangwa National Park (SLNP) and Chiawa Game Management Area (CGMA), against routine microscopy.…”

Section: 3mentioning

confidence: 99%

Preliminary Investigation of Trypanosomosis in Exotic Dog Breeds from Zambia's Luangwa and Zambezi Valleys Using LAMP

Namangala

Oparaocha²,

Kajino³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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“…In contrast, non-indigenous dogs may show a persistent high parasitemia and die rapidly after infection. Few imported cases of T. congolense infection have been reported during the past 20 years (Harrus et al, 1995;Davoust et al,2006b;Gow et al, 2007). The acute flare up of chronic disease could be due to the stress caused by environmental changes or an underlying disease process.…”

Section: Resultsmentioning

confidence: 99%

Epidemiological study of canine Trypanosomosis in an urban area of Ivory coast

et al. 2009

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Summary :Following confirmed cases of trypanosomosis in military working dogs, a cross-sectional study was undertaken to evaluate the source of infection and determine the prevalence of canine infection with Trypanosoma congolense in the urban focus of Abidjan, Ivory Coast. Blood from 123 dogs were collected and subjected to PCR using specific primers for Trypanosoma congolense "forest type". In addition, an entomological study was conducted in an urban area near the forest surronding the military camp. The observed prevalence was 30.1 % and PCR positivity to Trypanosoma congolense was not significantly associated with sex or age of animals. This study demonstrates the high contamination rate of dogs in enzootic zones, the potential risk of introduction of the disease in free animal populations and the ability of Glossina palpalis to adapt to urban areas and to transmit trypanosomosis in such areas. The factors leading to a possible emergence of canine trypanosomiasis in enzootic zones need further investigations. Résumé

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“…Also serum protein changes have been reported in trypanosomosis due to experimental T. brucei infection in West African Dwarf sheep (Ogunsanmi, 1994) T. vivax infection in sheep (Omotainse et al, 2000) and T. congolense infected sheep (Bisalla et al, 2007). Other biochemical changes that have been reported in trypanosomosis include hypoglycaemia (Anosa, 1988b), increased plasma bilirubin in T. brucei infected dogs (Omotainse et al, 1994), and rabbits (Arowolo et al, 1988) and in T. congolense infected dogs (Gow, et al, 2007). An increase in serum urea in rats experimentally infected with T. brucei have also been reported (Wellde et al, 1974;Egbe-Nwiyi et al, 2005) Information on on the haematological, pathological and serum biochemical alterations due to T. congolense infection in rabbits and from a single species of animal so as to relate these changes to the infection is scanty.…”

Section: Introductionmentioning

confidence: 99%

“…In this study, rabbits were challenged with T. congolense and the subsequent parasitaemia in relation to the haematological, biochemical and pathological changes monitored and reported. This research becomes imperative because of the increasing rate at which animal pets that could act as reservoirs of zoonotic and non-zoonotic diseases are been imported and exported in and out of different countries (Gow et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Haematological, pathological and plasma biochemical changes in rabbits experimentally infected with <i>Trypanosoma congolense</i>

Takeet¹,

Fagbemi²

2010

Science World Journal

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Chinchilla x New Zealand white cross breed rabbits (N=24)were challenged with strain of T. congolense. The infections were characterized by intermittent pyrexia, undulating parasitaemia, anorexia and emaciation. The major haematological changes observed were anaemia that was macrocytic normochromic at the first week of the infection and later became normochromic normocytic till the end of the experiment and leucopaenia that is characterized by neutropaenia, eosinopaenia and lymphocytosis. Plasma biochemical changes include hypoglycaemia, elevated total protein and plasma cholesterol. There were significant (p<0.05) elevation of Alkaline phospatase (ALP), Aspertate aminotransferase (AST), total bilirubin and fluctuating changes in the levels of plasma Alanine aminotransferase (ALT) and urea. Gross pathological changes include congested and oedematous lungs, mucoid enteritis, hepatomegaly and splenomegaly. Histopathological changes include mild congestion of the splenic pulp, mild venous congestion of the liver, pulmonary congestion, acute bronchopneumonia, severe emphysema of the lung, and focal centrilobular necrosis and periportal mononuclear cell aggregation in the kidney. This study shed light on the dynamics of haematological alteration and distortion of architectural frame work of various tissues of rabbits experimentally infected with T. congolense and suggested that rabbit is susceptible to T. congolense and could act as reservoir for trypanosomosis of ruminants and domesticated dogs used for hunting.

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First report of canine African trypanosomosis in the UK

Cited by 26 publications

References 12 publications

Preliminary Investigation of Trypanosomosis in Exotic Dog Breeds from Zambia's Luangwa and Zambezi Valleys Using LAMP

Preliminary Investigation of Trypanosomosis in Exotic Dog Breeds from Zambia's Luangwa and Zambezi Valleys Using LAMP

Epidemiological study of canine Trypanosomosis in an urban area of Ivory coast

Haematological, pathological and plasma biochemical changes in rabbits experimentally infected with <i>Trypanosoma congolense</i>

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