First Report of Bacillary Angiomatosis by Bartonella elizabethae in an HIV-Positive Patient

Corral, Julieta; Robles, Amairani Manríquez; Caire, Sonia Toussaint; Hernández‐Castro, Rigoberto; Moreno‐Coutiño, Gabriela

doi:10.1097/dad.0000000000001439

Cited by 10 publications

(6 citation statements)

References 14 publications

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“…B. quintana , the culprit of trench fever, and B. henselae which causes cat-scratch disease in immunocompetent persons can both cause bacillary angiomatosis in immunocompromised hosts 2 . In addition, the recently described B. elizabethae can also cause bacillary angiomatosis in HIV-positive patients 3 . Both bacillary angiomatosis and verruga peruana are characterized by the formation of hemangioma at skin lesions caused by abnormal endothelial cell proliferation 4 , 5 .…”

Section: Introductionmentioning

confidence: 99%

The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis

et al. 2020

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Pathogenic bacteria of the genus Bartonella can induce vasoproliferative lesions during infection. The underlying mechanisms are unclear, but involve secretion of an unidentified mitogenic factor. Here, we use functional transposon-mutant screening in Bartonella henselae to identify such factor as a pro-angiogenic autotransporter, called BafA. The passenger domain of BafA induces cell proliferation, tube formation and sprouting of microvessels, and drives angiogenesis in mice. BafA interacts with vascular endothelial growth factor (VEGF) receptor-2 and activates the downstream signaling pathway, suggesting that BafA functions as a VEGF analog. A BafA homolog from a related pathogen, Bartonella quintana, is also functional. Our work unveils the mechanistic basis of vasoproliferative lesions observed in bartonellosis, and we propose BafA as a key pathogenic factor contributing to bacterial spread and host adaptation.

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Section: Introductionmentioning

confidence: 99%

The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis

et al. 2020

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“…The potential new species described in this study are related genetically to B . elizabethae , a species that is currently recognised as a zoonotic agent responsible for endocarditis [ 30 ], neuroretinitis [ 30 , 31 ] and bacillary angiomatosis [ 32 ] in humans. Veterinarians also consider this bacterium as an infectious disease agent in canine medicine [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Detection of Potential Zoonotic Bartonella Species in African Giant Rats (Cricetomys gambianus) and Fleas from an Urban Area in Senegal

et al. 2022

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Bartonellae are bacteria associated with mammals and their ectoparasites. Rodents often host different species of Bartonella. The aim of this study was to investigate the presence of Bartonella spp. in African giant pouched rats (Cricetomys gambianus) and their ectoparasites in Dakar, Senegal. In 2012, 20 rats were caught, and their fleas were identified. DNA was extracted from 170 selected fleas and qPCR was carried out to detect Bartonella spp. Subsequently, a Bartonella culture was performed from the rat blood samples and the isolated strains (16S rRNA, rpoB, ftsZ and ITS3) were genotyped. A total of 1117 fleas were collected from 19 rats and identified as Xenopsylla cheopis, the tropical rat flea. Bartonella DNA was detected in 148 of 170 selected fleas (87.1%). In addition, Bartonella strains were isolated from the blood of 17 rats (85%). According to Bartonella gene-sequence-based criteria for species definition, the isolated strains were identified as B. massiliensis (four strains) and two potential new species related to the zoonotic B. elizabethae. In this paper, these potentially new species are provisionally called Candidatus Bartonella militaris (11 strains) and Candidatus Bartonella affinis (two strains) until their description has been completed. Cricetomys gambianus and its fleas could constitute a public health risk in Dakar due to the high prevalence of Bartonella infection reported.

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“…Recently, a case of bacillary angiomatosis caused by Bartonella elizabethae was reported in people possibly infected in Mexico (Corral et al . ). No studies have been published on Bartonella in cats or dogs from Mexico yet.…”

Section: Introductionmentioning

confidence: 97%

“…; Corral et al . ) because most reports are related to infection in wildlife and their potential vectors (Rubio et al . ; Schulte‐Fischedick et al .…”

Section: Introductionmentioning

confidence: 99%

Bartonella in dogs and fleas from Tulancingo, Hidalgo, Mexico

Tobar

Lapsley

Jaffe

et al. 2020

Medical Vet Entomology

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Bartonella sp. infection is quite common in free‐roaming dogs in many tropical countries. However, limited information is available of the presence of these pathogens in Mexico. The present study looked at prevalence of Bartonella exposure and/or infection in dogs and their fleas in Central Mexico. Blood samples were collected from 31 stray dogs in August 2014 at the municipal pound, Tulancingo, Mexico, as well as fleas on 26 of them. Bartonella seropositivity was 46.9%, including 35.5% for Bartonella henselae, 45% for Bartonella clarridgeiae and 32.2% for Bartonella vinsonii subsp. berkhoffii. Three (9.7%) dogs were polymerase chain reaction (PCR) positive for the Bartonella gltA gene. Partial sequencing of that gene revealed that these three dogs were infected with B. henselae. In total, 86 fleas were collected from 26 dogs (range 1–9 fleas per dog), including 52 Ctenocephalides felis and 34 Ctenocephalides canis. Of 40 pools of fleas (20 pools of C. canis and 20 pools of C. felis), five (12.5%) were PCR positive for the Bartonella sp. gltA gene, including three C. canis pools (five fleas) and two C. felis pools (three fleas). All sequences showed 99.25% to 100% homology with B. henselae Houston I.

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First Report of Bacillary Angiomatosis by Bartonella elizabethae in an HIV-Positive Patient

Cited by 10 publications

References 14 publications

The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis

The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis

Detection of Potential Zoonotic Bartonella Species in African Giant Rats (Cricetomys gambianus) and Fleas from an Urban Area in Senegal

Bartonella in dogs and fleas from Tulancingo, Hidalgo, Mexico

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