First Report of Autologous Cord Blood Transplantation in the Treatment of a Child With Leukemia

Hayani, Ammar; Lampeter, E. F.; Viswanatha, David S.; Morgan, David R.; Salvi, Sharad

doi:10.1542/peds.2006-1009

Cited by 66 publications

(43 citation statements)

References 17 publications

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“…Of note, some autologous transplants were for leukemia, a treatment modality that almost never occurs in the United States because of the concern that there would be no GvL activity in an autologous graft and also because of the potential for contamination of UCB with malignant cells. 50 Clinical trials for type 1 diabetes account for 7% of the autologous releases from family banks, but this treatment modality is currently not active because patient response to unmanipulated UCB stem cells was transient. 51 However, donorderived β-cell engraftment has been demonstrated in recipients of UCBT, suggesting that pancreatic cell precursors are present in UCB units.…”

Section: Private Ucb Bankingmentioning

confidence: 99%

Umbilical cord blood donation: public or private?

Ballen

Verter²,

Kurtzberg

2015

Bone Marrow Transplant

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Umbilical cord blood (UCB) is a graft source for patients with malignant or genetic diseases who can be cured by allogeneic hematopoietic cell transplantation (HCT), but who do not have an appropriately HLA-matched family or volunteer unrelated adult donor. Starting in the 1990s, unrelated UCB banks were established, accepting donations from term deliveries and storing UCB units for public use. An estimated 730 000 UCB units have been donated and stored to date and ∼ 35 000 UCB transplants have been performed worldwide. Over the past 20 years, private and family banks have grown rapidly, storing ∼ 4 million UCB units for a particular patient or family, usually charging an up-front and yearly storage fee; therefore, these banks are able to be financially sustainable without releasing UCB units. Private banks are not obligated to fulfill the same regulatory requirements of the public banks. The public banks have released ∼ 30 times more UCB units for therapy. Some countries have transitioned to an integrated banking model, a hybrid of public and family banking. Today, pregnant women, their families, obstetrical providers and pediatricians are faced with multiple choices about the disposition of their newborn's cord blood. In this commentary, we review the progress of UCB banking technology; we also analyze the current data on pediatric and adult unrelated UCB, including the recent expansion of interest in transplantation for hemoglobinopathies, and discuss emerging studies on the use of autologous UCB for neurologic diseases and regenerative medicine. We will review worldwide approaches to UCB banking, ethical considerations, criteria for public and family banking, integrated banking ideas and future strategies for UCB banking.

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Section: Private Ucb Bankingmentioning

confidence: 99%

Umbilical cord blood donation: public or private?

Ballen

Verter²,

Kurtzberg

2015

Bone Marrow Transplant

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“…По данным J. Passweg et al (EBMT, 2016), с 2007 по 2014 г. проведено очень не-большое количество ауто-ТГСК с использованием пуповинной крови: тяжелая АА (n = 6), НХЛ (n = 3), нейробластома (n = 3), МДС (n = 2), МПЗ (n = 1) и другое солидное злокачественное заболевание (n = 1) [13]. В то же время имеются единичные публи-кации об эффективности ауто-ТГСК с пуповинной кровью при ОЛЛ, когда после терапии рецидива ОЛЛ (нейролейкемия) 3-летней девочке была проведена миелоаблативная химиолучевая терапия и выполнена инфузия собственной пуповинной крови с последо-вавшей полной ремиссией в течение 20 мес наблюде-ния [102].…”

Section: гаплоидентичная трансплантация и профилактика реакции «трансunclassified

Allogeneic transplantation of hematopoietic stem cells: Perspectives and alternatives, own experience

Петрович¹,

Рукавицын²

2017

Ross. ž. det. gematol. onkol.

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“…Approximately 2000 children with hematological malignancies have been transplanted with related or unrelated cord blood transplantation from 1990 to 2008 [18]. The first report of autologous transplantation with UCB was made in 2007, by a group from Advocate Hope Children's Hospital of Ilinois, USA [21]. The patient was a three-year old girl with leukemia, whose chemotherapy had failed and thus the transplant became the only possibility for saving her.…”

Section: Clinical Datamentioning

confidence: 99%

Umbilical Cord Blood: Medical Waste or Important Source of Stem Cells?

Àlex¹,

Burlacu²

2013

Human Genet Embryol

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The identification of new sources of stem cells may provide significant clinical benefits in the regenerative medicine. Although sometimes still regarded as a medical waste, the blood remained in the umbilical vein after birth (Umbilical Cord Blood, UCB) has become a valuable alternative source of haematopoietic stem cells for the treatment of various disorders.Using UCB is advantageous because it is obtained by a simple, safe and painless procedure when the baby is delivered. The immaturity of UCB cells resulted in a reduced graft-versus-host disease when compared to bone marrow grafts. Furthermore, there may be particular utility in using UCB in the context of HLA mismatch between available donor and recipient. However, due to the limited number of stem cells, the progress in the field has been largely restricted to children. Nevertheless, evidence supporting the efficacy of a double transplant of UCB in adults has significantly increased over the past years, as an alternative to bone marrow transplantation in those adult patients where no compatible donors are available.Today, new parents may choose to have the UCB stored in a stem cell bank. These banks can be public (non-profit) or private (for-profit). The public banks store UCB from donors and provide it when transplantation is prescribed to an unrelated patient. Unfortunately, donation to a public bank is not possible everywhere, although their number is growing. On contrary, the private banks offer a commercial service to parents in order to preserve the UCB for future needs of their child. Storing UCB in such private banks is controversial and recommended only in the case of historical existence of a genetic disease; otherwise the likelihood of stored UCB being used in autologous transplant is negligible. This and other ethical aspects of UCB banking are discussed in this paper.

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First Report of Autologous Cord Blood Transplantation in the Treatment of a Child With Leukemia

Cited by 66 publications

References 17 publications

Umbilical cord blood donation: public or private?

Umbilical cord blood donation: public or private?

Allogeneic transplantation of hematopoietic stem cells: Perspectives and alternatives, own experience

Umbilical Cord Blood: Medical Waste or Important Source of Stem Cells?

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