First report of acute autochthonous hepatitis E in Portugal

Duque, Vítor; Ventura, Conceição; Seixas, Daniela; Cunha, Saraiva da; Meliço-Silvestre, A.

doi:10.3855/jidc.2078

Cited by 10 publications

(8 citation statements)

References 11 publications

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“…Further studies are necessary to better understand whether HEV seroprevalence both in human and in pigs is comparable with the current situation on HEV genotype 3 circulation worldwide but with the results presented in this study, it is clear that HEV is highly circulating in fact the first HEV autochthonous case has just been reported by Duque et al. (2012) in Portugal.…”

Section: Discussionsupporting

confidence: 68%

Detection and Characterization of Hepatitis E Virus in Domestic Pigs of Different Ages in Portugal

Berto

Mesquita

Honing

et al. 2012

Zoonoses and Public Health

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This study represents the primary hepatitis E virus (HEV) surveillance in domestic pigs in Portugal, five pig farms were investigated in 5 different Portuguese regions, ten faecal samples were collected at four different stages of the production. All faecal samples were tested for hepatitis E virus by real-time RT-PCR. At least one sample from each farms of all age groups tested positive for HEV. The prevalence in the pig herds varied from 10% to 30% and the mean prevalence was 32% in weaners, 20% in growers, 32% in fatteners and 4% in adult dry sows. Phylogenetic analysis of the detected HEV sequences indicated that the circulating virus strains belong under the genotype 3.

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Section: Discussionsupporting

confidence: 68%

Detection and Characterization of Hepatitis E Virus in Domestic Pigs of Different Ages in Portugal

Berto

Mesquita

Honing

et al. 2012

Zoonoses and Public Health

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“…In 1998 in Portugal, Duque et al carried out the first serological study to assess the presence of anti-HEV IgG in 50 blood donors and the results showed that 4% (2/50) were anti-HEV IgG positive [ 105 ]. In this country, the first cases of acute autochthonous hepatitis E virus in humans were described in 2010 [ 106 ].…”

Section: Seroprevalence In the General Population And Risk Groups mentioning

confidence: 99%

Epidemiology of Hepatitis E Virus in European Countries

Lapa

Capobianchi

Garbuglia

2015

IJMS

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Over the last decade the seroprevalence of immunoglobulin (IgG) anti hepatitis E virus (HEV) has been increasing in European countries and shows significant variability among different geographical areas. In this review, we describe the serological data concerning the general population and risk groups in different European countries. Anti-HEV antibody prevalence ranged from 1.3% (blood donors in Italy) to 52% (blood donors in France). Various studies performed on risk groups in Denmark, Moldova and Sweden revealed that swine farmers have a high seroprevalence of HEV IgG (range 13%–51.1%), confirming that pigs represent an important risk factor in HEV infection in humans. Subtypes 3e,f are the main genotypes detected in the European population. Sporadic cases of autochthonous genotype 4 have been described in Spain, France, and Italy. Although most HEV infections are subclinical, in immune-suppressed and transplant patients they could provoke chronic infection. Fulminant hepatitis has rarely been observed and it was related to genotype 3. Interferon and ribavirin treatment was seen to represent the most promising therapy.

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“…HEV RNA was also detected at each of three sites (production, processing, and point of sale) in the pork food supply chain. An autochthonous HEV infection was recently described in Portugal in a patient who recalled eating traditional homemade pork sausages made of raw meat about 2 weeks prior to the development of the clinical manifestations of acute hepatitis (Duque et al, 2012). Renou et al (2014) presented the case of the direct evidence of foodborne transmission of HEV after consumption of uncooked "figatellu" sausage in France, with 100% identity between the sequences from the patient and the food product.…”

Section: Viruses In Food-viruses In Fresh Foodmentioning

confidence: 99%

Viral Contamination of Food

D’Agostino

2016

Antimicrobial Food Packaging

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First report of acute autochthonous hepatitis E in Portugal

Cited by 10 publications

References 11 publications

Detection and Characterization of Hepatitis E Virus in Domestic Pigs of Different Ages in Portugal

Detection and Characterization of Hepatitis E Virus in Domestic Pigs of Different Ages in Portugal

Epidemiology of Hepatitis E Virus in European Countries

Viral Contamination of Food

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