First report of a <i><scp>K</scp>lebsiella pneumoniae</i> strain coproducing <scp>NDM</scp>‐1, <scp>VIM</scp>‐1 and <scp>OXA</scp>‐48 carbapenemases isolated in <scp>M</scp>orocco

Barguigua, Abouddihaj; Otmani, Fatima El; yaagoubi, Fouzia Lakbakbi el; Talmi, Mustapha; Zerouali, Khalid; Timinouni, Mohammed

doi:10.1111/apm.12034

Cited by 43 publications

(36 citation statements)

References 15 publications

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“…Endemicity of VIM- and IMP-producing Klebsiella pneumoniae strains has now been noted in Greece [8, 41]. Additionally, outbreaks and single reports of VIM- or IMP-type producers have been reported in several countries of Mediterranean area, such as France [50, 51], Spain [33], Morocco [52], Egypt [53, 54], Algeria [55], and Tunisia [56]. …”

Section: Class B Carbapenemasesmentioning

confidence: 99%

Epidemiology of Carbapenemase-Producing Enterobacteriaceae andAcinetobacter baumanniiin Mediterranean Countries

Djahmi

Dunyach-Rémy

Pantel

et al. 2014

BioMed Research International

146

140

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The emergence and global spread of carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii are of great concern to health services worldwide. These β-lactamases hydrolyse almost all β-lactams, are plasmid-encoded, and are easily transferable among bacterial species. They are mostly of the KPC, VIM, IMP, NDM, and OXA-48 types. Their current extensive spread worldwide in Enterobacteriaceae is an important source of concern. Infections caused by these bacteria have limited treatment options and have been associated with high mortality rates. Carbapenemase producers are mainly identified among Klebsiella pneumoniae, Escherichia coli, and A. baumannii and still mostly in hospital settings and rarely in the community. The Mediterranean region is of interest due to a great diversity and population mixing. The prevalence of carbapenemases is particularly high, with this area constituting one of the most important reservoirs. The types of carbapenemase vary among countries, partially depending on the population exchange relationship between the regions and the possible reservoirs of each carbapenemase. This review described the epidemiology of carbapenemases produced by enterobacteria and A. baumannii in this part of the world highlighting the worrisome situation and the need to screen and detect these enzymes to prevent and control their dissemination.

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Section: Class B Carbapenemasesmentioning

confidence: 99%

Epidemiology of Carbapenemase-Producing Enterobacteriaceae andAcinetobacter baumanniiin Mediterranean Countries

Djahmi

Dunyach-Rémy

Pantel

et al. 2014

BioMed Research International

146

140

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“…Earlier studies showed the presence of NDM CPE in Cameroon (51), Kenya (24), Morocco (25,52), and South Africa (53), while North Africa has also been described as a region where A. baumannii with NDMs has spread (54,55). Comparative analysis of the pMC-NDM and pGUE-NDM plasmids indicates the probable evolution of NDM-1 genetic determinants proceeding on a large geographic scale.…”

mentioning

confidence: 97%

The First NDM Metallo-β-Lactamase-Producing Enterobacteriaceae Isolate in Poland: Evolution of IncFII-Type Plasmids Carrying the bla _NDM-1 Gene

Fiett

Baraniak

Izdebski

et al. 2014

Antimicrob Agents Chemother

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bPoland's first Enterobacteriaceae isolate producing the New Delhi metallo-␤-lactamase (NDM) was identified in August 2011. Escherichia coli sequence type ST410 NDM-1 was cultured from a critically ill patient who had been transferred directly from the Congo. The bla NDM-1 gene was carried by conjugative IncFII-type plasmid pMC-NDM (87,619 bp), which showed structural similarity to plasmid pGUE-NDM, which was identified earlier in France in an E. coli ST131 isolate of Indian origin.

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“…On the Indian subcontinent, where NDM-1 is endemic, variants of OXA-48, including OXA-181 and OXA-232, also seem to be spreading among Enterobacteriaceae (6,7). As a consequence of the rapid spread of these two groups of carbapenemases, the coproduction of NDM-1 and OXA-48 group carbapenemases is also increasingly reported in Enterobacteriaceae (8)(9)(10)(11)(12)(13)(14)(15)(16). However, the genetics supporting the coacquisition of multiple carbapenemase genes have not been elucidated.…”

mentioning

confidence: 99%

Whole-Genome Assembly of Klebsiella pneumoniae Coproducing NDM-1 and OXA-232 Carbapenemases Using Single-Molecule, Real-Time Sequencing

Doi

Hazen

Boitano

et al. 2014

Antimicrob Agents Chemother

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The whole-genome sequence of a carbapenem-resistant Klebsiella pneumoniae strain, PittNDM01, which coproduces NDM-1 and OXA-232 carbapenemases, was determined in this study. The use of single-molecule, real-time (SMRT) sequencing provided a closed genome in a single sequencing run. K. pneumoniae PittNDM01 has a single chromosome of 5,348,284 bp and four plasmids: pPKPN1 (283,371 bp), pPKPN2 (103,694 bp), pPKPN3 (70,814 bp), and pPKPN4 (6,141 bp). The contents of the chromosome were similar to that of the K. pneumoniae reference genome strain MGH 78578, with the exception of a large inversion spanning 23.3% of the chromosome. In contrast, three of the four plasmids are unique. The plasmid pPKPN1, an IncHI1B-like plasmid, carries the bla NDM-1 , armA, and qnrB1 genes, along with tellurium and mercury resistance operons. bla NDM-1 is carried on a unique structure in which Tn125 is further bracketed by IS26 downstream of a class 1 integron. The IncFIA-like plasmid pPKPN3 also carries an array of resistance elements, including bla CTX-M-15 and a mercury resistance operon. The ColE-type plasmid pPKPN4 carrying bla OXA-232 is identical to a plasmid previously reported from France. SMRT sequencing was useful in resolving the complex bacterial genomic structures in the de novo assemblies.

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First report of a Klebsiella pneumoniae strain coproducing NDM‐1, VIM‐1 and OXA‐48 carbapenemases isolated in Morocco

Cited by 43 publications

References 15 publications

Epidemiology of Carbapenemase-Producing Enterobacteriaceae andAcinetobacter baumanniiin Mediterranean Countries

Epidemiology of Carbapenemase-Producing Enterobacteriaceae andAcinetobacter baumanniiin Mediterranean Countries

The First NDM Metallo-β-Lactamase-Producing Enterobacteriaceae Isolate in Poland: Evolution of IncFII-Type Plasmids Carrying the bla _NDM-1 Gene

Whole-Genome Assembly of Klebsiella pneumoniae Coproducing NDM-1 and OXA-232 Carbapenemases Using Single-Molecule, Real-Time Sequencing

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First report of a Klebsiella pneumoniae strain coproducing NDM‐1, VIM‐1 and OXA‐48 carbapenemases isolated in Morocco

Cited by 43 publications

References 15 publications

Epidemiology of Carbapenemase-Producing Enterobacteriaceae andAcinetobacter baumanniiin Mediterranean Countries

Epidemiology of Carbapenemase-Producing Enterobacteriaceae andAcinetobacter baumanniiin Mediterranean Countries

The First NDM Metallo-β-Lactamase-Producing Enterobacteriaceae Isolate in Poland: Evolution of IncFII-Type Plasmids Carrying the bla NDM-1 Gene

Whole-Genome Assembly of Klebsiella pneumoniae Coproducing NDM-1 and OXA-232 Carbapenemases Using Single-Molecule, Real-Time Sequencing

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The First NDM Metallo-β-Lactamase-Producing Enterobacteriaceae Isolate in Poland: Evolution of IncFII-Type Plasmids Carrying the bla _NDM-1 Gene