First report and genetic characterization of porcine astroviruses of lineage 4 and 2 in diarrhoeic pigs in India

Kattoor, Jobin Jose; Malik, Yashpal Singh; Saurabh, Sharad; Sircar, Shubhankar; Vinodhkumar, Obli Rajendran; Bora, Durlav Prasad; Dhama, Kuldeep; Ghosh, Souvik; Bányai, Krisztiàn; Touil, Nadia; Abdel‐Moneim, Ahmed S.; Vlasova, Anastasia N.; Kobayashi, Nobumichi; Singh, Raj Kumar

doi:10.1111/tbed.13058

Cited by 24 publications

(34 citation statements)

References 39 publications

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“…and Qin et al (22). In contrast, the prevalence of PAstV-4 is reportedly higher than that of PAstV-2 in Thailand, South Korea, and India (5,6,12). Sequence analysis of the 27 RdRp genes identified in this study had nucleotide identities of 53.8-99.5%, indicating (4)(5)(6)12).…”

Section: Phylogenetic Analysis Of Pastvmentioning

confidence: 53%

“…A previous surveillance study conducted by our group found a high percentage of coinfection among diarrheic piglets (9). PAstV, which has been identified as an important agent of diarrhea (10), and frequently presents as a coinfection with other porcine pathogens (3,5,6,9,11). However, data regarding coinfections with PAstV in diarrheic piglets in China are limited.…”

Section: Introductionmentioning

confidence: 85%

“…In contrast, the prevalence of PAstV-4 is reportedly higher than that of PAstV-2 in Thailand, South Korea, and India (5,6,12). Sequence analysis of the 27 RdRp genes identified in this study had nucleotide identities of 53.8-99.5%, indicating (4)(5)(6)12). PAstV-4, which was first reported in 2013, is a newly identified genotype in China that has since spread to the provinces of Hunan, Tianjin, Shanxi, Jilin, and Jiangxi (9,21,22).…”

Section: Phylogenetic Analysis Of Pastvmentioning

confidence: 90%

“…The average number of viruses detected in each sample was 4.12, while 75.28% (67/89) of samples had three to five different viruses, 3.37% (3/89) had seven to eight different viruses, and none were positive for PAstV only ( Figure 1B). Coinfections of PAstV with other porcine pathogens, such as rotavirus, PEDV, TGEV, porcine circovirus-2 (PCV2), and porcine hemagglutinating encephalomyelitis virus (PHEV), have been reported previously (3,5,6,11). In the present study, the rate of PKV coinfection in PAstV-positive samples was relatively high (85.39%, 76/89), and there was evidence that u shed more PKV than did healthy individuals (18), indicating that PKV may have a potential role in PAstV-induced diarrhea in piglets.…”

Section: Coinfection Of Pastv With Multiple Porcine Pathogens In Diarmentioning

confidence: 98%

“…PAstV was first identified in diarrheic piglets in 1980 (1). Since then, PAstV has been isolated worldwide, including Europe, Asia, and the Americas (1,(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

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Coinfection and Genetic Characterization of Porcine Astrovirus in Diarrheic Piglets in China From 2015 to 2018

Yang

et al. 2020

Front. Vet. Sci.

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Porcine astrovirus (PAstV) is broadly distributed globally and exists as at least five distinct genotypes. PAstV, which was recently identified as an important pathogen of diarrhea in piglets, is widely distributed in China. However, few studies have investigated the coinfection and genetic characterization of PAstV in diarrheic piglets in China. In this study, 89 PAstV-positive samples were identified in 543 diarrhea samples in China from 2015 to 2018, of which 75.28% (67/89) were coinfected with three to five different porcine pathogens, while none were positive for PAstV only. Among the 543 diarrhea samples, statistical analysis showed that PAstV-induced diarrhea was potentially associated with coinfection of PEV (p < 0.01) and GARV (p < 0.01). Phylogenetic analysis showed that the 27 identified PAstV strains belong to three different genotypes and that PAstV-2 (81.48%, 22/27) was predominant in diarrheic piglets in China, followed by PAstV-4 (11.11%, 3/27) and PAasV-5 (7.41%, 2/27). Sequence analysis revealed that the 27 RdRp genes identified in this study had nucleotide homologies of 53.8-99.5%. In addition, the RdRp gene of PAstV-4 strain JL/MHK/2018/0115 harbored a unique insert of three nucleotides (GAA) as compared with other known PAstV-4 strains. Furthermore, the genotypes of PAstV varied among different geographical locations, although PAstV-2 was the most widely distributed in China. These data demonstrate that PAstV coinfection with other porcine pathogens was common and there was genetic diversity of PAstV in diarrheic piglets in China.

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Section: Phylogenetic Analysis Of Pastvmentioning

confidence: 53%

Section: Introductionmentioning

confidence: 85%

Section: Phylogenetic Analysis Of Pastvmentioning

confidence: 90%

Section: Coinfection Of Pastv With Multiple Porcine Pathogens In Diarmentioning

confidence: 98%

“…PAstV was first identified in diarrheic piglets in 1980 (1). Since then, PAstV has been isolated worldwide, including Europe, Asia, and the Americas (1,(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations