First recorded case of haemoglobin SC in sudan

Elderdery, Abozer Y.; Mohamed, Babiker Ahmed; Mijalli, Samiah Hamad Al; Mills, Jeremy

doi:10.7243/2052-434x-2-2

Cited by 1 publication

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References 25 publications

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“…According to Bain, the prevalence of HbS, HbC and β-thalassemia in Sudan is 1-17%, 0%, and 1-10% (overall prevalence: 4%), respectively (11). However, Elderdery et al reported two cases with HbSC in Sudan (11,12). They also reported the S gene as the most common variant among the Western tribes (12%) and the general Sudanese population (6.1%) (13).…”

Section: Discussionmentioning

confidence: 99%

Genotyping of Individuals with Hemoglobinopathies in Beja Tribes and Other Minor Groups in Port Sudan, Eastern Sudan

et al. 2018

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Background and objectives: This study aimed to characterize the spectrum of β-thalassemia mutations and haplotypes of sickle cell anemia in Beja tribes and other minor groups living in Port Sudan, Sudan. Methods: This descriptive cross-sectional study was carried out from March 2011 to July 2013. Overall, 209 anemic patients were screened for hemoglobinopathy by capillary electrophoresis. The subjects were genotyped for β-thalassemia mutation by amplified refractory mutation system and for sickle cell haplotype by restriction-fragment length polymorphism. Results: Of the 209 patients, 29 (13.87%) showed the typical-88(C→T) βthalassemia mutation and 27 (12.91%) had sickle cell anemia, of whom 15 (55.6%) were heterozygous AS and 12 (44.4%) were homozygous SS. Based on results of the restrictionfragment length polymorphism; all subjects were with Benin haplotype (Benin/Benin). Conclusion: Based on the results of this study, it is recommended to perform a potential carrier screening for the-88 (C→T) mutation and sickle cell Benin haplotype by DNA analysis.

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Section: Discussionmentioning

confidence: 99%