First Prize: Characterization of Renal Ischemia Using DLP<sup>®</sup>Hyperspectral Imaging: A Pilot Study Comparing Artery-Only Occlusion Versus Artery and Vein Occlusion

Tracy, Chad R.; Terrell, John D.; Francis, Robert P.; Wehner, Eleanor; Smith, Jack; Litorja, Maritoni; Hawkins, Darnell F.; Pearle, Margaret S.; Cadeddu, Jeffrey A.; Zuzak, Karel J.

doi:10.1089/end.2009.0184

Cited by 41 publications

(34 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous works in this field evaluated tissue perfusion of in vivo perfused kidneys and proposed HSI for postoperative assessment Tracy et al, 2010;Holzer et al, 2011;Zuzak et al, 2011;Crane et al, 2008). In addition to the characterization of water-enriched tissue around 970 nm, the analysis of lipid-sensitive regions in the spectral NIR band might be interesting for the correlation with ischemic injury (van Veen et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Hyperspectral imaging for monitoring oxygen saturation levels during normothermic kidney perfusion

Tetschke

Markgraf

Gransow

et al. 2016

J. Sens. Sens. Syst.

View full text Add to dashboard Cite

Abstract. The development of improved preservation techniques and the reliable assessment of donor grafts are main fields of research in transplantation medicine. Normothermic machine perfusion (NMP) is a promising alternative to static cold storage of organs, maintaining physiological conditions during preservation. In combination with NMP, we introduce hyperspectral imaging (HSI) as a novel approach for the monitoring of physiological kidney parameters. A line-scan HSI camera system was used to record images of porcine kidneys during NMP. Based on a dual-wavelength algorithm, the oxygen saturation levels were calculated from HSI recordings. Furthermore, we observed HSI images in the near-infrared (NIR) range in order to detect water characteristics of the kidney tissue. We found increasing levels of oxygenation during NMP and could discriminate between perfused and non-perfused areas. Cysts at the renal capsula were characterized by an absorption increase in the NIR band. Within this work, we showed that HSI is able to detect relevant chemical changes during NMP and allows the identification of pathologic variations.

show abstract

Section: Discussionmentioning

confidence: 99%

Hyperspectral imaging for monitoring oxygen saturation levels during normothermic kidney perfusion

Tetschke

Markgraf

Gransow

et al. 2016

J. Sens. Sens. Syst.

View full text Add to dashboard Cite

show abstract

“…13 Additionally, 3-CCD contrast enhancement was used to compare renal oxygenation post-reperfusion to renal oxygenation before hilar clamping. 13 Zuzak and coworkers 30,31 have monitored tissue oxygenation intraoperatively with a DLP® hyperspectral imaging system, at near-video frame rates, to study the effects of artery-only clamping and ice slush application on renal oxygenation. 32 Their results indicated that artery-only clamping and 7-10 min of ice slush application can help to minimize the decrease in renal oxygenation during partial nephrectomies.…”

Section: Discussionmentioning

confidence: 99%

Evidence of a heterogeneous tissue oxygenation: renal ischemia/reperfusion injury in a large animal model

Crane¹,

Huffman

Alemozaffar

et al. 2013

J. Biomed. Opt

View full text Add to dashboard Cite

Abstract. Renal ischemia that occurs intraoperatively during procedures requiring clamping of the renal artery (such as renal procurement for transplantation and partial nephrectomy for renal cancer) is known to have a significant impact on the viability of that kidney. To better understand the dynamics of intraoperative renal ischemia and recovery of renal oxygenation during reperfusion, a visible reflectance imaging system (VRIS) was developed to measure renal oxygenation during renal artery clamping in both cooled and warm porcine kidneys. For all kidneys, normothermic and hypothermic, visible reflectance imaging demonstrated a spatially distinct decrease in the relative oxy-hemoglobin concentration (%HbO 2 ) of the superior pole of the kidney compared to the middle or inferior pole. Mean relative oxy-hemoglobin concentrations decrease more significantly during ischemia for normothermic kidneys compared to hypothermic kidneys. VRIS may be broadly applicable to provide an indicator of organ ischemia during open and laparoscopic procedures. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

show abstract

“…Studies by other researchers have also demonstrated the effectiveness of this approach for assessing perfusion of the retina, 7 brain, 8 and kidneys. 9 Spectral reflectance imaging has also been used to investigate cold and warm ischaemia-reperfusion injury on the kidneys.…”

Section: Optical Imaging Of Hemodynamicsmentioning

confidence: 99%

Multispectral imaging of organ viability during uterine transplantation surgery in rabbits and sheep

et al. 2016

View full text Add to dashboard Cite

Abstract. Uterine transplantation surgery (UTx) has been proposed as a treatment for permanent absolute uterine factor infertility (AUFI) in the case of the congenital absence or surgical removal of the uterus. Successful surgical attachment of the organ and its associated vasculature is essential for the organ's reperfusion and long-term viability. Spectral imaging techniques have demonstrated the potential for the measurement of hemodynamics in medical applications. These involve the measurement of reflectance spectra by acquiring images of the tissue in different wavebands. Measures of tissue constituents at each pixel can then be extracted from these spectra through modeling of the light-tissue interaction. A multispectral imaging (MSI) laparoscope was used in sheep and rabbit UTx models to study short-and long-term changes in oxygen saturation following surgery. The whole organ was imaged in the donor and recipient animals in parallel with point measurements from a pulse oximeter. Imaging results confirmed the re-establishment of adequate perfusion in the transplanted organ after surgery. Cornual oxygenation trends measured with MSI are consistent with pulse oximeter readings, showing decreased StO 2 immediately after anastomosis of the blood vessels. Long-term results show recovery of StO 2 to preoperative levels. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

show abstract

First Prize: Characterization of Renal Ischemia Using DLP^®Hyperspectral Imaging: A Pilot Study Comparing Artery-Only Occlusion Versus Artery and Vein Occlusion

Cited by 41 publications

References 15 publications

Hyperspectral imaging for monitoring oxygen saturation levels during normothermic kidney perfusion

Hyperspectral imaging for monitoring oxygen saturation levels during normothermic kidney perfusion

Evidence of a heterogeneous tissue oxygenation: renal ischemia/reperfusion injury in a large animal model

Multispectral imaging of organ viability during uterine transplantation surgery in rabbits and sheep

Contact Info

Product

Resources

About

First Prize: Characterization of Renal Ischemia Using DLP®Hyperspectral Imaging: A Pilot Study Comparing Artery-Only Occlusion Versus Artery and Vein Occlusion

Cited by 41 publications

References 15 publications

Hyperspectral imaging for monitoring oxygen saturation levels during normothermic kidney perfusion

Hyperspectral imaging for monitoring oxygen saturation levels during normothermic kidney perfusion

Evidence of a heterogeneous tissue oxygenation: renal ischemia/reperfusion injury in a large animal model

Multispectral imaging of organ viability during uterine transplantation surgery in rabbits and sheep

Contact Info

Product

Resources

About

First Prize: Characterization of Renal Ischemia Using DLP^®Hyperspectral Imaging: A Pilot Study Comparing Artery-Only Occlusion Versus Artery and Vein Occlusion