First polymorphisms in JY-1 gene in cattle (Bos taurus indicus) and their association with sexual precocity and growth traits

Camargo, Gregório Miguel Ferreira de; Cardoso, Diércles Francisco; Gil, Fernanda Maria Monsalves; Fonseca, Patrícia Dias da Silva; Zetouni, Larissa; Braz, Camila Urbano; Freitas, Amílcar Chagas; Souza, Fernanda Fernandes; Aspilcueta-Borquis, Rusbel Raúl; Baldi, Fernando; Albuquerque, Lúcia Galvão de; Regitano, Luciana Correia de Almeida; Tonhati, Humberto

doi:10.1007/s11033-012-1884-5

Cited by 10 publications

(12 citation statements)

References 13 publications

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“…The significance of the 3' untranslated region for JY-1 is not known, but based on accumulating evidence for important regulatory roles (polyadenylation, translation efficiency, localization and stability of the mRNA) of noncoding RNAs (Prasanth & Spector, 2007), a functional role for the observed mutation cannot be discounted. The regions amplified in the present study have been shown to have seven SNPs in cattle (de Camargo et al, 2012). The haplotypes of four of these SNPs were found to be correlated with sexual precocity in Nellore heifers at 8%.…”

Section: Resultsmentioning

confidence: 49%

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First-Time Characterization of <i>JY-1</i>-Like Sequence in Goats

et al. 2015

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The JY-1 protein is oocyte specific, and is associated with folliculogenesis and early embryo development, and thus influences the chance of pregnancy. It was the first protein of maternal origin to be described for a single ovulating species, namely cattle. JY-1-like sequences corresponding to 3' coding and the untranslated region have been reported in other vertebrate species. This is the first description of the partial JY-1 (exon 3 and 3'UTR) in a livestock species other than cattle and buffalo. The sequence was characterized in a panel of nine Indian goat breeds, which differ in reproductive traits (twinning percentage and age of sexual maturity). Forty three variations were recorded in the analysed region of goats JY-1 compared with cattle. Nucleotide variations in the codifying region of goats correspond to seven amino acid changes that could affect the biological function of the protein and possibly reproductive differences between goats (higher proportion of multiparous animals) and cattle (mainly uniparous). A novel single nucleotide polymorphism (C15329T) has been identified in Indian goats, which was genotyped in 272 animals from six breeds. Further studies to investigate other regions of the gene and its expression in goat female reproductive tissues would clarify the role of JY-1 in farm animal species that are not primarily uniparous. ______________________________________________________________________________________

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Section: Resultsmentioning

confidence: 49%

“…Black Begal, Barbari, Beetal, Osmanabadi and Sangamneri each contributed 48 animals, while 32 animals were of the Jakhrana breed. Two pairs of primers were utilized to amplify the exon 3 and 3'UTR of the JY-1 gene (Table 2), as reported in cattle (Camargo et al, 2012). The primers were synthesized by IDT (Integrated DNA Technologies, Inc.).…”

Section: Methodsmentioning

confidence: 99%

First-Time Characterization of <i>JY-1</i>-Like Sequence in Goats

et al. 2015

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“…Role of the 3 0 untranslated region for the JY-1 is not known, but based on accumulating evidence for important regulatory roles (polyadenylation, translation efficiency, localization, and stability of the mRNA) of noncoding RNAs [12], a functional role for the observed mutation cannot be discounted. The regions amplified in present study have been shown to have seven SNPs in cattle [2]. The haplotypes of four of these SNPs were found to be correlated with sexual precocity in Nellore heifers at 8 %.…”

Section: Resultsmentioning

confidence: 51%

“…JY-1 like sequences corresponding to 3 0 coding and untranslated region have been reported in other vertebrate species viz. human, chimpanzee, dog, mouse, and rat [2]. However, the syntenic loci do not encode for the complete JY-1 gene and lack sequences corresponding to exons 1 and 2 and thus a significant portion of the protein coding region.…”

Section: Introductionmentioning

confidence: 99%

Polymorphism of JY-1 gene is not associated with reproductive traits in goats

et al. 2015

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Reproductive traits show either low to moderate heritability and are measured late in life. Thus molecular markers are required to improve the pace of genetic gain in these traits of economic value. Recent publications report the association of polymorphism in JY-1 gene with cattle reproductive traits. In this study, the only known single nucleotide polymorphism (C15329T) of caprine JY-1 gene was explored for its association with reproductive traits; age at first heat, age at first service and age at first kidding. Black Bengal (n = 70), a sexually precocious and prolific goat breed of India was genotyped for the SNP by designing PCR-RFLP. Effect of year of birth and genotype was found to be non-significant at 1% for all three traits. However, the effect of season of birth was highly significant (p ≤ 0.01) on age at first kidding. Polymorphism in 3'UTR of the JY-1 gene is not associated with the reproductive traits of goats. In future, studies involving large number of animals from different goat breeds as well as investigation of other regions of this gene would be exciting to perform.

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“…Interestingly, it has been demonstrated that maternal-effect genes not only involved in early embryo development but also contribute to the genetic variability of reproductive traits. The association between JY-1 polymorphisms and reproductive traits such as pregnancy probability, age at first calving, and days to first calving has been characterized (de Camargo et al, 2012(de Camargo et al, , 2014. However, relatively few maternal-effect genes have been identified, and the functions and mechanisms of these genes in early embryogenesis are largely unknown.…”

Section: Q3mentioning

confidence: 99%