First Living Related Kidney Transplantation Results in Excellent Outcomes for Small Children

Aikawa, Atsushi; Arai, Kenji; Kawamura, T; Sugiyama, Ken; Muramatsu, Masaki; Itabashi, Yoshihiro; Ohara, Takahiro; Motoyama, Osamu; Hasegawa, Akira

doi:10.1016/j.transproceed.2005.06.095

Cited by 11 publications

(9 citation statements)

References 2 publications

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“…The guideline for transplantation using a kidney from an adult living related donor recommends a recipient weight >8 kg 15 . Results of transplantation in small infants and young children were comparable with those in older children 2,15,16 . Patient survival rate was 93% and graft survival rate was 86% for the mean follow‐up period of 4.9 ± 5.8 years (range, 0.1–18.2 years) in 14 patients under 5 years of age at transplantation at Toho University Medical Center, Omori Hospital.…”

Section: Discussionmentioning

confidence: 87%

“…They received the first living‐related renal transplantation at a mean age of 2.5 ± 1.3 years (range, 0.8–4.9 years) and weight of 9.0 ± 1.6 kg (range, 6.6–11.6 kg). Transplantation of adult kidneys into children was performed as described previously 2 . At the last evaluation, their creatinine clearance was >80 mL/min per 1.73m 2 .…”

Section: Methodsmentioning

confidence: 99%

“…These complications usually improve after successful renal transplantation. We have previously reported a catch‐up of growth and development and changes in the electroencephalogram (EEG) and cranial computed tomography (CT) after transplantation 2–4 . Head circumference (HC) is an important growth index and there is a close relation between HC growth, estimated brain weight, and development in young children 5 .…”

mentioning

confidence: 99%

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Head circumference and development in young children after renal transplantation

Motoyama

Kawamura

Aikawa

et al. 2009

Pediatrics International

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Section: Discussionmentioning

confidence: 87%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Head circumference and development in young children after renal transplantation

Motoyama

Kawamura

Aikawa

et al. 2009

Pediatrics International

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“…This low risk to the donor seems to be justified by the socioeconomic advantages and increased quality of life of the recipient, mostly when living kidney transplantation is performed in a preuremic phase [38,39 ]. Growth during the first 5 years after transplant was retrospectively studied in 30 boys who received a living-related transplant, compared with 21 who received a deceased-donor graft.…”

Section: Living Donationmentioning

confidence: 99%

Historical review and perspectives in pediatric transplantation

Otte¹

2006

Current Opinion in Organ Transplantation

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Purpose of reviewRecent progress in organ transplantation in children is illustrated by analysis of the most informative papers published during [2005][2006]. Recent findingsThe review focuses on immunosuppression, steroid withdrawal or avoidance, living-related transplantation, long-term survival, drug-related nephrotoxicity, growth, and quality of life in solid organ transplantation. Summary Research on better, more selective, and safer immunosuppression must be pursued as well as the search for surrogate markers of tolerance. Long-term analysis is needed of quality of life beyond 10-15 years after transplantation. Abbreviations cGFR calculated glomerular filtration rate HRQL health-related quality of life IMD inherited metabolic disorder LRLT living-related liver transplantation OLT orthotopic liver transplant PELD Pediatric End-Stage Liver Disease scoring system PTLD posttransplant lymphoproliferative disorder rhGH recombinant human growth hormone UNOS United Network for Organ Sharing ß

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“…Improvements in surgical techniques, donor selection, and immunosuppression practices have led to marked improvements in patients and kidney graft survival for infants and young children. Pediatric recipients under age 11 who received living donor kidney transplants had five‐year graft survival rates that were as good or better than most older age groups (80% for those aged 6–10 yr) (3–6).…”

mentioning

confidence: 99%

Pediatric renal transplantation with mycophenolate mofetil immunosuppression in a single center from Mexico

Martínez-Mier¹,

Méndez-López²,

Budar-Fernández³

et al. 2006

Pediatric Transplantation

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An MMF-based immunosuppression has reduced the acute rejection rate in adults and in children in the early post-transplantation period. In the present study, pediatric renal transplantation patients on a CyA, MMF, and steroids regimen were prospectively evaluated. Patients with CyA, MMF, and steroid therapy without antibody induction were evaluated for surgical aspects, renal function, rejection, and survival, growth after transplantation, adverse events and medication discontinuation. Between February 2003 and May 2005, 21 kidney transplantation patients under 18 yr old were followed for at least 12 months. Within one year after transplantation, three patients developed four episodes of acute rejection (19%). Graft loss because of rejection occurred in one patient. One-year mean serum creatinine was 1.19 +/- 0.3 mg/dL. Mean calculated CrCl by Schwartz formula was 82.3 +/- 19.7 mL/min*1.73 m(2). Major adverse events included infections of the urinary tract and diarrhea, abdominal pain, and GI symptoms. No patients have discontinued the use of MMF. Good results in pediatric kidney transplantation can be achieved by using CyA/MMF/steroids. MMF is effective and relatively safe in reducing the incidence of acute rejection even without induction therapy 12 months after transplantation.

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First Living Related Kidney Transplantation Results in Excellent Outcomes for Small Children

Cited by 11 publications

References 2 publications

Head circumference and development in young children after renal transplantation

Head circumference and development in young children after renal transplantation

Historical review and perspectives in pediatric transplantation

Pediatric renal transplantation with mycophenolate mofetil immunosuppression in a single center from Mexico

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