First‐line antibiotic treatment in patients with localized extragastric mucosa‐associated lymphoid tissue lymphoma

Abstract

Between January 2010 and December 2015, we enrolled 28 patients with stage IEI/IIE1 extragastric mucosa‐associated lymphoid tissue (MALT) lymphoma who received first‐line antibiotic treatment, after informing them about the pros and cons of alternative therapies. In addition, during the same period, 64 patients with stage IE/IIE1 disease who received conventional treatment were selected as the control group. The most common primary sites were the ocular adnexal area (17 cases), followed by the salivary glands (four cases), pulmonary (three cases), and thyroid, trachea, larynx, and colon region (one case each). First‐line antibiotic treatment resulted in an overall response rate of 57.1%: 12 patients achieved complete remission (CR), while four achieved partial remission (antibiotic‐responsive tumors). Monoclonal gammopathy was significantly prevalent in antibiotic‐unresponsive tumors than in antibiotic‐responsive tumors (50.0% [6/12] vs. 12.5% [2/16], p = 0.044). After a median follow‐up of 7 years, all patients with CR remained lymphoma‐free, with 7‐year event‐free survival (EFS) and overall survival (OS) rates of 62.7% and 96.4%, respectively. The 7‐year EFS and OS rates of patients who received conventional treatments were 73.1% and 91.1%, respectively. Compared with that noted in patients who received conventional treatment, antibiotic treatment was effective in some patients with localized extragastric MALT lymphoma.

A case of endobronchial mucosa‐associated lymphoid tissue (MALT) lymphoma successfully treated with radiotherapy and a review of the literature

“…To the best of our knowledge, only 48 cases have been reported in the literature, including English‐language articles and 2 abstracts in English from conference presentations 1–38 . Furthermore, there has been only one report that reviewed the literature with 20 cases 4 .…”

“…To the best of our knowledge, only 48 cases have been reported in the literature, including English‐language articles and 2 abstracts in English from conference presentations. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 Furthermore, there has been only one report that reviewed the literature with 20 cases. 4 We believe our review of 49 cases herein will provide valuable information and serve as a useful clinical reference for this rare disease.…”

“…We herein report a case of EML that was diagnosed through a chest computed tomography (CT) during an annual health checkup which was successfully treated with radiotherapy. To the best of our knowledge, only 48 cases of EML have been reported in the literature 1–38 . To date, a comprehensive review of this rare condition is not available.…”

“…To the best of our knowledge, only 48 cases of EML have been reported in the literature. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 To date, a comprehensive review of this rare condition is not available. Therefore we believe reporting our case with a review of current literature will be useful for patients and providers who may encounter this disease in the future.…”