First-in-man Implantation of a Cardiac Microcurrent Device for Chronic Systolic Heart Failure

Schmitto, Jan D.; Napp, L. Christian; Mariani, Silvia; Hanke, Jasmin S.; Li, Tong; Vogel‐Claussen, Jens; Brandes, K.; Göttel, Peter; Müller, Johannes; Dogan, Guenes; Bauersachs, Johann; Haverich, Axel

doi:10.1097/mat.0000000000001537

Cited by 2 publications

(4 citation statements)

References 9 publications

(14 reference statements)

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“…There is, however, a dire need to understand the underlying mechanisms of how cells behave upon electrical stimulation. We believe our study, combined with these existing human studies [ 14 , 15 ], contributes significantly to the understanding of microcurrent therapy for cardiac care. Additionally, findings from prior studies with CMs [ 12 , 13 ] along with our current study demonstrate that microcurrent treatment not only exerts a positive influence on the gene expression patterns of myofibroblasts but also promotes CM proliferation.…”

Section: Discussionmentioning

confidence: 75%

“…Furthermore, it is important to note that devices for electrical stimulation of organs with a weak constant electrical current are in clinical testing and have shown promising results [ 14 , 15 ]. There is, however, a dire need to understand the underlying mechanisms of how cells behave upon electrical stimulation.…”

Section: Discussionmentioning

confidence: 99%

“…In vivo studies on rat hearts have shown that electric stimuli regulate the expression of ECM components and their inhibitors, accompanied by a significant decrease in pro-inflammatory cytokines [ 12 , 13 ]. Furthermore, recent studies with a Cardio-microcurrent device concluded that weak constant electrical current application to the heart is not only feasible and safe but also shows promising results in heart function and size [ 14 , 15 ]. Considering these promising outcomes observed with rat cardiomyocytes and preliminary clinical applications, this study specifically aimed to unveil the mechanism by which myofibroblasts respond to electrical stimulation to promote cardiac functional recovery.…”

Section: Introductionmentioning

confidence: 99%

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Microcurrent-Mediated Modulation of Myofibroblasts for Cardiac Repair and Regeneration

Bachamanda Somesh,

Jürchott,

Giesel

et al. 2024

IJMS

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Cardiovascular diseases are a significant cause of illness and death worldwide, often resulting in myofibroblast differentiation, pathological remodeling, and fibrosis, characterized by excessive extracellular matrix protein deposition. Treatment options for cardiac fibrosis that can effectively target myofibroblast activation and ECM deposition are limited, necessitating an unmet need for new therapeutic approaches. In recent years, microcurrent therapy has demonstrated promising therapeutic effects, showcasing its translational potential in cardiac care. This study therefore sought to investigate the effects of microcurrent therapy on cardiac myofibroblasts, aiming to unravel its potential as a treatment for cardiac fibrosis and heart failure. The experimental design involved the differentiation of primary rat cardiac fibroblasts into myofibroblasts. Subsequently, these cells were subjected to microcurrent (MC) treatment at 1 and 2 µA/cm2 DC with and without polarity reversal. We then investigated the impact of microcurrent treatment on myofibroblast cell behavior, including protein and gene expression, by performing various assays and analyses comparing them to untreated myofibroblasts and cardiac fibroblasts. The application of microcurrents resulted in distinct transcriptional signatures and improved cellular processes. Gene expression analysis showed alterations in myofibroblast markers, extracellular matrix components, and pro-inflammatory cytokines. These observations show signs of microcurrent-mediated reversal of myofibroblast phenotype, possibly reducing cardiac fibrosis, and providing insights for cardiac tissue repair.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Microcurrent-Mediated Modulation of Myofibroblasts for Cardiac Repair and Regeneration

Bachamanda Somesh,

Jürchott,

Giesel

et al. 2024

IJMS

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“…Microcurrent provides electrical stimulation to nerve fibres through cutaneous electrodes, using lower current than transcutaneous electrical nerve stimulation (TENS) [ 6 ]. Microcurrent is best known for skin healing with reduction of inflammation, improved local blood circulation, and improved mitochondrial function [ 7 ], and has even recently been adapted for direct cardiac application to improve reduced ejection fraction heart failure [ 8 ]. Wound healing is improved by microcurrent energy through alterations in cell metabolism, changes in extracellular matrix and proinflammatory signals [ 9 ].…”

mentioning

confidence: 99%

Evaluation of visual acuity in dry AMD patients after microcurrent electrical stimulation

Parkinson¹,

Sayre²,

Tobe³

2023

Int J Retin Vitr

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Background To assess micro current to improve vision for dry age-related macular degeneration. Dry age-related macular degeneration is a major cause of blindness, disability, and severe erosion of quality of life, throughout the world. Beyond nutritional supplementation, there is no approved therapy. Methods This was a prospective randomized sham controlled clinical trial for participants with confirmed dry AMD with documented visual loss. Participants were randomized three to one, to receive transpalpebral external micro current electrical stimulation with the MacuMira device. The Treatment group received four treatments in the first two weeks, and two further treatments at weeks 14 and 26. Differences in BCVA and contrast sensitivity (CS) were estimated with mixed-effects repeated measures analysis of variance. Results Change of visual acuity with ETDRS assessment of number of letters read (NLR) and contrast sensitivity at week 4 and 30, compared to the first visit, between 43 treatment and 19 sham control participants. The Sham Control group had NLR of 24.2 (SD 7.1) at baseline, 24.2 (SD 7.2) at 4 weeks, and 22.1 (SD7.4) at 30 weeks. The Treatment group had NLR of 19.6 (SD 8.9) at baseline, 27.6 (SD 9.1) at 4 weeks, and 27.8 (SD 8.4) at 30 weeks. The change in NLR from baseline in the Treatment compared to the Sham control group was 7.7 (95% CI 5.7, 9.7, p < 0.001) at 4 weeks and 10.4 (95% CI 7.8, 13.1, p < 0.001) at 30 weeks. There were similar benefits in CS. Conclusions This pilot study of transpalpebral microcurrent demonstrated improved visual measures and is very encouraging as a potential treatment for dry AMD. Trial Registration: NCT02540148, ClinicalTrials.gov.

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First-in-man Implantation of a Cardiac Microcurrent Device for Chronic Systolic Heart Failure

Cited by 2 publications

References 9 publications

Microcurrent-Mediated Modulation of Myofibroblasts for Cardiac Repair and Regeneration

Microcurrent-Mediated Modulation of Myofibroblasts for Cardiac Repair and Regeneration

Evaluation of visual acuity in dry AMD patients after microcurrent electrical stimulation

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