First‐in‐Human Phase 1 Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of DISC‐0974, an Anti‐Hemojuvelin Antibody, in Healthy Participants
Natasha Novikov,
Akshay Buch,
Hua Yang
et al.
Abstract:Pathologic elevations in hepcidin, a key regulator of iron homeostasis, contribute to anemia of inflammation in chronic disease. DISC‐0974 is a monoclonal antibody that binds to hemojuvelin and blocks bone morphogenetic protein signaling, thereby suppressing hepcidin production. Reduction of systemic hepcidin levels is predicted to increase iron absorption and mobilize stored iron into circulation, where it may be utilized by red blood cell (RBC) precursors in the bone marrow to improve hemoglobin levels and t… Show more
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