First-in-Class: Cervical cancer diagnosis based on a urine test with fluorescent cysteine probe

In Situ Activatable Nitrobenzene–Cysteine–Copper(II) Nano-complexes for Programmed Photodynamic Cancer Therapy

“…This could be attributed to the over-enhanced ROS levels. It has been reported that ROS generation by PDT could stimulate the immune system. − In comparison to the PBS-treated group, the CyP -treated group exhibited increased levels of Endostatin/collagen XVIII, MMP-3, Coagulation Factor III, IL-1a, PEDF, IL-1b, and CD26 proteins, indicating a potential promotion of angiogenesis. However, upon irradiation with light, the protein levels of these angiogenic factors decreased.…”

“…Our research group has primarily focused on developing bioactive materials based on organic–inorganic hybrids to enhance their biocompatibility, disease targeting, and therapeutic efficiency. − Recently, we have focused on nitrobenzene derivatives that can be activated by stimuli such as biomolecules and photoirradiation, − and we designed a way to utilize biomolecule-/photo-reactive nitrobenzene-based metal-coordinated nano-complexes for cancer therapy in this work. Among the metal ions, copper­(II) is particularly noteworthy due to its anti-cancer effect, achieved by depleting GSH .…”

Pentafluorobenzene: Promising Applications in Diagnostics and Therapeutics

“…Figure b and c illustrates the selective detection of Cys in urine samples. The authors have applied probe 12 for diagnosing cervical cancer by monitoring Cys in urine samples …”

“…The authors have applied probe 12 for diagnosing cervical cancer by monitoring Cys in urine samples. 70 The intermolecular hydrogen bonding capability of fluorine molecules has inspired researchers to design molecular probes. Huang and co-workers reported a series of aggregation-induced phosphorescent emission (AIPE) active platinum complexes 14, 15, and their derivatives as thermosensitive molecules for intracellular temperature imaging (Figure 5a).…”

“…(Right) Illustration of an imaging framework for human-derived cancer cell and tissue (refer to the web version of this article to view the legend color). Reproduced from ref with permission from Elsevier. (b) The emission spectra of urine samples in the presence of 12 (100 μM) with/without additional Cys (10 ng/μL).…”