First identification of the MHC‐DPB2 alleles in the rhesus macaques (<i>Macaca mulatta</i>)

Yf, Yao; Yy, Zhou; Xu, Huailiang

doi:10.1111/tan.13255

Cited by 1 publication

(1 citation statement)

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“…Comparisons and relevance have been made to the human MHC and other gene families [ 44 , 45 , 46 , 47 ], with technological advances facilitating progress [ 48 , 49 , 50 ]. Inroads have also been made into characterization of other subspecies of rhesus macaque, including Burmese and Chinese-origin rhesus macaques [ 51 , 52 , 53 ]. Genetic studies of other NHP species such as baboons and sooty mangabeys [ 54 , 55 ] have also been described.…”

Section: Specific Host Mhc Differences In Nhps Used In Biomedical Res...mentioning

confidence: 99%

The Impact and Effects of Host Immunogenetics on Infectious Disease Studies Using Non-Human Primates in Biomedical Research

Berry,

Mee,

Almond

et al. 2024

Microorganisms

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Understanding infectious disease pathogenesis and evaluating novel candidate treatment interventions for human use frequently requires prior or parallel analysis in animal model systems. While rodent species are frequently applied in such studies, there are situations where non-human primate (NHP) species are advantageous or required. These include studies of animals that are anatomically more akin to humans, where there is a need to interrogate the complexity of more advanced biological systems or simply reflect susceptibility to a specific infectious agent. The contribution of different arms of the immune response may be addressed in a variety of NHP species or subspecies in specific physiological compartments. Such studies provide insights into immune repertoires not always possible from human studies. However, genetic variation in outbred NHP models may confound, or significantly impact the outcome of a particular study. Thus, host factors need to be considered when undertaking such studies. Considerable knowledge of the impact of host immunogenetics on infection dynamics was elucidated from HIV/SIV research. NHP models are now important for studies of emerging infections. They have contributed to delineating the pathogenesis of SARS-CoV-2/COVID-19, which identified differences in outcomes attributable to the selected NHP host. Moreover, their use was crucial in evaluating the immunogenicity and efficacy of vaccines against COVID-19 and establishing putative correlates of vaccine protection. More broadly, neglected or highly pathogenic emerging or re-emergent viruses may be studied in selected NHPs. These studies characterise protective immune responses following infection or the administration of candidate immunogens which may be central to the accelerated licensing of new vaccines. Here, we review selected aspects of host immunogenetics, specifically MHC background and TRIM5 polymorphism as exemplars of adaptive and innate immunity, in commonly used Old and New World host species. Understanding this variation within and between NHP species will ensure that this valuable laboratory source is used most effectively to combat established and emerging virus infections and improve human health worldwide.

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Section: Specific Host Mhc Differences In Nhps Used In Biomedical Res...mentioning

confidence: 99%

The Impact and Effects of Host Immunogenetics on Infectious Disease Studies Using Non-Human Primates in Biomedical Research

Berry,

Mee,

Almond

et al. 2024

Microorganisms

View full text Add to dashboard Cite

show abstract

First identification of the MHC‐DPB2 alleles in the rhesus macaques (Macaca mulatta)

Abstract: We report here the identification of three MHC-DPB2 alleles in the rhesus macaques (Macaca mulatta).

Cited by 1 publication

References 5 publications

The Impact and Effects of Host Immunogenetics on Infectious Disease Studies Using Non-Human Primates in Biomedical Research

The Impact and Effects of Host Immunogenetics on Infectious Disease Studies Using Non-Human Primates in Biomedical Research

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