First identification of reciprocal translocations in Polish pigs

Danielak-Czech, B.; Świtoński, M.; Słota, E.

doi:10.1111/j.1439-0388.1997.tb00493.x

Cited by 13 publications

(12 citation statements)

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“…Almost 60% of them were reported to be involved in reciprocal translocations, common karyotype rearrangement, formed in majority de novo and associated with considerably reduced fertility in this species (about 50% decreased litter size on an average) (Gustavsson, 1990;Danielak-Czech et al, 1996). Several autosomal unstable regions were unmasked on chromosome 13 (seven fragile sites) and identified as the breakpoints in eight translocations identified in population studies (Long, 1991;Danielak-Czech et al, 1997;Pinton et al, 2000). By contrast, the X-specific fragile sites have been observed rarely and one of them only (Xp2.1) was correlated to the translocation breakpoint.…”

Section: Discussionmentioning

confidence: 99%

Mutagen-induced chromosome instability in farm animals

Danielak-Czech¹,

Słota²

2004

J. Anim. Feed Sci.

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The frequencies of spontaneous and in vitro mutagen-induced unstable chromosomal lesions were compared in the groups of subfertile cows, ewes and sows (test groups) as well as the animals without any reproductive disturbances (control groups). The mean percentage of 5-azacytidineand bromodeoxyuridine-induced defects differed statistically between the test and control groups (P≤0.01 in cattle, P≤0.05 in sheep and pigs). In the groups of animals with reproductive problems the number of defects observed in some chromosomes exceeded the expected values (calculated according to the relative chromosome length), but only in the case of X chromosome differed at the level of statistical significance. Moreover, the groups of cows analysed differed significantly as regards the number of chromatid breaks/gaps at the Xq2.4 and Xq3.1 fragile sites. The excessive chromosome instability in subfertile farm animals, particularly the X-specific loci, may result in inappropriate expression of genes determining reproductive traits as well as in the increased rate of aneuploid germ cells related to prenatal and perinatal mortality.

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Section: Discussionmentioning

confidence: 99%

Mutagen-induced chromosome instability in farm animals

Danielak-Czech¹,

Słota²

2004

J. Anim. Feed Sci.

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“…Since that time, 11 new reciprocal translocations have been published: rcp(8;14)(p21;q25) and rcp(7;13)(q13;q46) [7], rcp(2;9;14)(q23;q22;q25) and rcp(7;15)(q24;q26) [20], rcp(13;17)(q41;q11) and rcp(2;14)(q13;q27) [9], rcp(8;10)(p11;q13) [22], rcp(1;7)(q17;q26), rcp(4;12)(p13;q13) and rcp(1;6)(q17;q35) [25], and a 1q+/15q− translocation [18]. Including the eight new cases reported here, the total number of reciprocal translocations known in the pig species is presently 87.…”

Section: Discussionmentioning

confidence: 99%

Cytogenetic and molecular characterization of eight new reciprocal translocations in the pig species. Estimation of their incidence in French populations

et al. 2002

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-Eight new cases of reciprocal translocation in the domestic pig are described. All the rearrangements were highlighted using GTG banding techniques. Chromosome painting experiments were also carried out to confirm the proposed hypotheses and to accurately locate the breakpoints. Three translocations, rcp(4;6)(q21;p14), rcp(2;6)(p17;q27) and rcp(5;17)(p12;q13) were found in boars siring small litters (8.3 and 7.4 piglets born alive per litter, on average, for translocations 2/6 and 5/17, respectively). The remaining five, rcp(5;8)(p12;q21), rcp(15;17)(q24;q21), rcp(7;8)(q24;p21), rcp(5;8)(p11;p23) and rcp(3;15)(q27;q13) were identified in young boars controlled before entering reproduction. A decrease in prolificacy of 22% was estimated for the 3/15 translocation after reproduction of the boar carrier. A parental origin by inheritance of the translocation was established for the (5;8)(p11;p23) translocation.

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“…The overall rate of chromosomal rearrangements in hypoprolific boars in service is close to 50 % and its prevalence in young untested AI boar candidates is 0.47 % [ 6 ]. This most probably reflects the rate of “de novo” abnormalities, since in other less intensively tested populations the frequency of abnormalities is usually much higher according to reports from Poland (1 %), the Netherlands (1.5 %) and Spain (3.4 %) [ 5 , 7 , 8 ]. Prior to this study, a systematical screening for chromosome abnormalities was not implemented in Canada but a few cases have been identified in Canadian pig populations, including a rcp(Xp+;14q−) [ 9 , 10 ], rcp(1;6)(p22,q12), rcp(10;13), and rcp(9;14)(p24;q27) [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and consequences of chromosomal abnormalities in Canadian commercial swine herds

et al. 2016

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BackgroundStructural chromosome abnormalities are well known as factors that reduce fertility rate in domestic pigs. According to large-scale national cytogenetic screening programs that are implemented in France, it is estimated that new chromosome abnormalities occur at a rate of 0.5 % in fertility-unproven boars.ResultsThis work aimed at estimating the prevalence and consequences of chromosome abnormalities in commercial swine operations in Canada. We found pig carriers at a frequency of 1.64 % (12 out of 732 boars). Carrier pigs consistently showed lower fertility values. The total number of piglets born for litters from carrier boars was between 4 and 46 % lower than the herd average. Similarly, carrier boars produced litters with a total number of piglets born alive that was between 6 and 28 % lower than the herd average. A total of 12 new structural chromosome abnormalities were identified.ConclusionsReproductive performance is significantly reduced in sires with chromosome abnormalities. The incidence of such abnormal sires appears relatively high in populations without routine cytogenetic screening such as observed for Canada in this study. Systematic cytogenetic screening of potential breeding boars would minimise the risk of carriers of chromosome aberrations entering artificial insemination centres. This would avoid the large negative effects on productivity for the commercial sow herds and reduce the risk of transmitting abnormalities to future generations in nucleus farms.Electronic supplementary materialThe online version of this article (doi:10.1186/s12711-016-0246-5) contains supplementary material, which is available to authorized users.

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First identification of reciprocal translocations in Polish pigs

Cited by 13 publications

References 16 publications

Mutagen-induced chromosome instability in farm animals

Mutagen-induced chromosome instability in farm animals

Cytogenetic and molecular characterization of eight new reciprocal translocations in the pig species. Estimation of their incidence in French populations

Prevalence and consequences of chromosomal abnormalities in Canadian commercial swine herds

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