First Human Infection of Nocardia Crassostreae in an Immunocompetent Patient

Igbaseimokumo, Usiakimi; Shafie, Sittana El; Khal, Abdul Latif Al

doi:10.4103/0366-6999.172609

Cited by 8 publications

(7 citation statements)

References 4 publications

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“…However, other environmental factors such as reduced water circulation of superficial embayments, warmest temperatures and great nutrient levels can also increase the prevalence of infection of nocardiosis ( Bower et al, 2005 ) as also reported in the PN station as showed by Chl-a values. Interestingly, recent reports assessed for the first time infection of N. crassostreae as emerging human pathogen causing invasive pulmonary nocardiosis in immunosuppressed and immunocompetent patients ( Taj-Aldeen et al, 2013 ; Igbaseimokumo et al, 2016 ). This data suggest N. crassostreae to be a possible emerging disease with consequent possible risk of zoonotic infections.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Health Status of Mussels Mytilus galloprovincialis Along the Campania Coastal Areas: A Multidisciplinary Approach

et al. 2018

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The bivalve Mytilus galloprovincialis has a broad geographic distribution, represent an important species for the ecology of coastal waters, also constituting a major aquaculture species. In the present work, molecular and tissue biomarkers were examined in mussel populations (M. galloprovincialis) located in four different areas of the coastal water of the Campania Region. During an annual life cycle, we analyzed the expression patterns of several genes commonly used to estimate cellular stress response and damage, namely p53, p63, HSP70, MT-10, and MT-20, related tissue lesions (pathogens, inflammations, digestive tubules damage), oxidative stress indicators (H2O2, SOD specific activity) and associated environmental data. The computed Principal Component Analysis showed that the areas were discernible based on the environmental data and biomarker results. About animal health status, mussels from Gulf of Pozzuoli and Naples’s harbor did show a thinnest epithelial cell of digestive tubules compared to mussels sampled from other sampling sites; moreover, high prevalence of cases of intersex in three of the examinated areas were observed. The presence of a potential zoonotic pathogen (Nocardia crassostreae) was identified, appearing as an important possible emerging disease. We also reported the OIE notifiable protozoa Marteilia refringens in three areas out of four. The likely impact of both observed pathogens on the mussel health and shellfish aquaculture needs to be urgently addressed. Results are discussed considering animal histopathological health parameters and biological effects.

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Section: Discussionmentioning

confidence: 99%

Assessment of the Health Status of Mussels Mytilus galloprovincialis Along the Campania Coastal Areas: A Multidisciplinary Approach

et al. 2018

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“…Nocardiosis usually manifests in the pulmonary system, the central nervous system (CNS), or the subcutaneous tissue (6)(7)(8). Pulmonary nocardiosis is the most common clinical manifestation and is mainly acquired through inhalation of the organism from environment.…”

Section: Introductionmentioning

confidence: 99%

Microbiological and clinical data analysis of 32 patients with Nocardia infections in Yantai

Yu¹,

Liu²,

Pu³

et al. 2018

Turk J Med Sci

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Background/aim: Nocardia is an opportunistic pathogen that mostly affects hosts with immune deficiencies. Recently, the widespread use of immunosuppressive agents and antitumor drugs has led to an increasing number of Nocardia infections being reported. However, it is difficult to confirm this diagnosis owing to the slow growth of the bacterium and its complex resultant clinical manifestations, potentially delaying treatment and increasing mortality. Thus, further knowledge on the clinical characteristics of Nocardia infection is required. Hence, this study aimed to review the demographics, comorbidities, clinical presentation, microbiology, treatment, and outcomes of Nocardia infections in Yantai. Materials and methods:This is a retrospective study including 32 patients identified to have Nocardia infection from the Yantai Yuhuangding Hospital. The relevant patient samples were collected by two researchers, while the other researchers analyzed the relevant data. Results:The male to female ratio among the 32 patients was 3:5, and 23 patients (71.9%) were immunocompromised. Pulmonary sites of infection were the most common (65.6% of patients). N. brasiliensis infections were present in 25.0% and N. asteroides infections were present in 21.9% of patients. Because of limited biotechnological resources, Nocardia spp. in 50.0% of cases were not classified. The TMP-SMX resistance rate among isolates was 9.4%. All isolates were susceptible to amikacin, ceftriaxone, and imipenem. Conclusion:In Yantai, immunocompromised patients predominate among cases of Nocardia infection. The rate of occurrence was higher in females than in males. Because of potential TMP-SMX resistance, treatment for Nocardia infection should be based on drug susceptibility or should include combination therapy.

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“… Carella et al (2013) observed this disease in Mediterranean bivalves first time. In 2013 ( Taj-Aldeen et al, 2013 ) and 2016 ( Igbaseimokumo et al, 2016 ), two outbreaks of N. crassostrea were observed in immunocompromised patients independently. No comprehensive information about genes responsible for antibiotic-resistance or antibiogram analysis was available.…”

Section: The Most Popular Gram-positive Pathogenic Bacteria In Molluscsmentioning

confidence: 99%

“…No comprehensive information about genes responsible for antibiotic-resistance or antibiogram analysis was available. Igbaseimokumo et al (2016) added information about antibiogram results. N. crassostrea , in this analysis, was sensitive to beta-lactams, including carbapenems but was resistant to lincosamides (clindamycin), vancomycin, and teicoplanin.…”

Section: The Most Popular Gram-positive Pathogenic Bacteria In Molluscsmentioning

confidence: 99%

Molluscs—A ticking microbial bomb

Kijewska

Koroza²,

Grudlewska‐Buda³

et al. 2023

Front. Microbiol.

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Bivalve shellfish consumption (ark shells, clams, cockles, and oysters) has increased over the last decades. Following this trend, infectious disease outbreaks associated with their consumption have been reported more frequently. Molluscs are a diverse group of organisms found wild and farmed. They are common on our tables, but unfortunately, despite their great taste, they can also pose a threat as a potential vector for numerous species of pathogenic microorganisms. Clams, in particular, might be filled with pathogens because of their filter-feeding diet. This specific way of feeding favors the accumulation of excessive amounts of pathogenic microorganisms like Vibrio spp., including Vibrio cholerae and V. parahaemolyticus, Pseudomonas aeruginosa, Escherichia coli, Arcobacter spp., and fecal coliforms, and intestinal enterococci. The problems of pathogen dissemination and disease outbreaks caused by exogenous bacteria in many geographical regions quickly became an unwanted effect of globalized food supply chains, global climate change, and natural pathogen transmission dynamics. Moreover, some pathogens like Shewanella spp., with high zoonotic potential, are spreading worldwide along with food transport. These bacteria, contained in food, are also responsible for the potential transmission of antibiotic-resistance genes to species belonging to the human microbiota. Finally, they end up in wastewater, thus colonizing new areas, which enables them to introduce new antibiotic-resistance genes (ARG) into the environment and extend the existing spectrum of ARGs already present in local biomes. Foodborne pathogens require modern methods of detection. Similarly, detecting ARGs is necessary to prevent resistance dissemination in new environments, thus preventing future outbreaks, which could threaten associated consumers and workers in the food processing industry.

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First Human Infection of Nocardia Crassostreae in an Immunocompetent Patient

Cited by 8 publications

References 4 publications

Assessment of the Health Status of Mussels Mytilus galloprovincialis Along the Campania Coastal Areas: A Multidisciplinary Approach

Assessment of the Health Status of Mussels Mytilus galloprovincialis Along the Campania Coastal Areas: A Multidisciplinary Approach

Microbiological and clinical data analysis of 32 patients with Nocardia infections in Yantai

Molluscs—A ticking microbial bomb

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