First human experience with angiopeptin-eluting stent: A quantitative coronary angiography and three-dimensional intravascular ultrasound study

Abstract

Angiopeptin has been shown to reduce in-stent restenosis in various animal models. Meanwhile, BiodivYsio DD phosphorylcholine (PC)-coated stent provides a platform for local delivery of antiproliferative agents to the coronary artery. We studied the feasibility, safety, and impact on tissue growth of angiopeptin-eluting BiodivYsio DD PC-coated stents in human native de novo coronary lesions. We enrolled 14 patients (16 lesions) who underwent intravascular ultrasound (IVUS)-guided angiopeptin-eluting stent implantation in native coronary arteries between 3.0 and 4.0 mm in diameter with lesion length<or=18 mm. We successfully implanted 13 stents loaded with 22 microg of angiopeptin and three stents with 126 microg of angiopeptin. No major adverse cardiac events or target vessel failure occurred at 1-year clinical follow-up. All patients underwent 6-month angiographic and volumetric IVUS follow-up. In-stent late loss was 0.46+/-0.32 mm in the low-dose group and 0.26+/-0.14 mm in the high-dose group. Binary restenosis rate was 0%. Follow-up percentage neointimal hyperplasia by IVUS was 18.4%+/-22.5% for the low-dose group and 10.2%+/-5.8% for the high-dose group, respectively. There were no edge effect and late stent malapposition. Angiopeptin-eluting BiodivYsio DD PC stent appears feasible and safe in treating native de novo coronary lesions with modest degree of neointimal hyperplasia.

Highly lubricated polymer interfaces for advanced artificial hip joints through biomimetic design

“…44 Highly lubricated polymer interfaces K Ishihara Administration (FDA) of the United States; therefore, the efficacy and safety of MPC polymers as a biomaterial are well established. [63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80] Surface properties of hydrophilic polymers grafted on X-UHMWPE: comparison of the chemical structure of graft polymer chains The graft polymerization process resulted in the formation of uniform polyelectrolyte layers on the X-UHMWPE surface, as observed from the cross-sectional transmission electron microscopy images in Figure 9a; the thickness of these layers was 100-150 nm. As shown in Figure 9b, the dynamic friction coefficients for the polyelectrolytegrafted X-UHMWPE samples ranged from 0.01 to 0.05, representing a 40-85% reduction compared with those of untreated X-UHMWPE.…”

Coronary stents: A materials perspective

“…A non-randomized trial investigated the PC coating-based elution of dexamethasone and reported the binary restenosis rate of 13.3% for 60 patients at 6 months [189]. Recently, a human clinical trial successfully evaluated the release of angiopeptin from a PC-coated stent and showed encouraging results [190].…”

Local Delivery of Therapeutics for Percutaneous Coronary Intervention

“…The Dexamet stent has also been shown to have an improved lumen restoration compared to BMS by angiographic analysis [74]. Other agents investigated include angiopeptin [60,128], estradiol [80], batimastat [76], c-myc antisense oligonucleotide [91] and therapeutic genes [129][130][131].…”