First-Generation Autologous Chondrocyte Implantation in Patients With Cartilage Defects of the Knee: 7 to 14 Years' Clinical and Magnetic Resonance Imaging Follow-up Evaluation

Articular cartilage solutions for the knee: present challenges and future direction

“…Clinical outcomes were overall good and MRI findings in 30 patients demonstrated that 70% had complete filling of the lesion 69. A mid-term trial from a different centre including 27 patients treated for chondral or osteochondral lesions confirmed these results and demonstrated good potential at 5-year follow-up 68. However, a recent study of six knees demonstrated incomplete regeneration of the cartilage and poor subchondral bone repair, with the authors urging caution for future use 70.…”

“…The MaioRegen scaffold (FinCeramica Faenza, Italy) is a multilayered biomaterial consisting of collagen type I and magnesium-hydroxyapatite 68. It had reported good preclinical results in an animal model, and therefore clinical trials were conducted.…”

Magnetic Resonance Imaging of Cartilage Repair Procedures

“…68 Mild underfilling of the defect may be asymptomatic; symptoms are more often seen in patients with defect filling of less than 50%. 91 In the early postoperative period, the repair tissue with all techniques frequently appears brighter than normal cartilage, sometimes similar to joint fluid. As the cells form extracellular matrix, the signal intensity of the repair becomes similar to that of native cartilage.…”

Surgical Restoration/Repair of Articular Cartilage Injuries in Athletes

“…45 An additional study from Sweden by Moradi et al, had a clinical followup of patients ranging from 7 to14 years following ACI. 46 More that 50% of the patients had MRI evidence of complete defect filling at final follow up and nearly 75% of patients said theywould undergo the procedure again. 46 The results of ACI for treatment of patellofemoral lesions appear to be very encouraging, with several studies reporting good to excellent results in .…”