First experiences with high-density silicone oil (Densiron) as an intraocular tamponade in complex retinal detachment

Sandner, Dirk; Engelmann, Katrin

doi:10.1007/s00417-005-0110-8

Cited by 70 publications

(112 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A few studies have reported on the use of 'Heavy Silicone Oil' for RD. [11][12][13][14] Indications for the use of heavy oil includes PVR, RD with inferior breaks and inability to posture. Variable anatomical results have been reported using Densiron with up to 81% reattachment rates with single surgery in one series 11 and 46% reattachment in another, 12 although the latter study recruited only complex PVR cases.…”

Section: Discussionmentioning

confidence: 99%

“…13 In some series, heavy oil emulsification has been reported to be low, with little or no clinical impact. 11,13,14 However, Sandner and Engelmann 12 reported emulsification of Densiron in seven out of 48 patients with pseudo-hypopyon formation in four patients. For this reason, they routinely performed anterior chamber irrigation upon Densiron removal.…”

Section: Discussionmentioning

confidence: 99%

“…Densiron-68 is a solution of perfluorohexyloctane (F 6 H 8 ) and 5000 mPas silicone oil, with viscosity 1387 mPas 3 and has been promoted for prolonged inferior retinal tamponade, particularly as it has similar physical properties to silicone oil in terms of the shape of the bubble. 11 Previous studies 11,12 and promotional product literature (Fluoron Co, Neu-Ulm, Germany) claim that clinically significant Densiron emulsification is not seen, although others have reported significant emulsification. 13 We have identified 40 patients with Densiron insertion over a 24-month period.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Emulsification of Densiron-68 used in inferior retinal detachment surgery

Majid

Hussin

Biswas

et al. 2007

Eye

View full text Add to dashboard Cite

Purpose To report the clinical features of eight patients presenting with emulsification of the heavier than water vitreous substitute, Densiron-68. Methods Two patients underwent primary inferior retinal detachment (RD) surgery, two patients underwent giant retinal tear repair, three patients had repair of inferior RD complicated by proliferative vitreoretinopathy and one patient had inferior RD surgery following repair of a scleral rupture. All patients had insertion of Densiron-68. Results Significant emulsification of Densiron-68 was seen within 12 weeks of surgery in eight cases out of a total of 40 patients receiving Densiron-68. Conclusion Despite adequate Densiron fills, emulsification necessitated its removal. Emulsified Densiron may have contributed to significant intraocular inflammation, epiretinal membrane formation and cystoid macular oedema. Without removal, prolonged presence of emulsified Densiron may lead to keratopathy, secondary glaucoma and retinal toxicity secondary to partitioning of perfluorohexyloctane. This has potentially significant implications on the indications for Densiron-68 use and warrants consideration before deciding on the optimal surgical intervention for inferior RDs.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Emulsification of Densiron-68 used in inferior retinal detachment surgery

Majid

Hussin

Biswas

et al. 2007

Eye

View full text Add to dashboard Cite

show abstract

“…18,19 Following the relative disappointment with these early heavy tamponades, we now seem to have entered a phase in which we might see the introduction of these vitreous substitutes into routine clinical use. Three recently developed heavy tamponades, Oxane HD, Densiron 68 and HWS 46-3000, have demonstrated better results and fewer complications compared to the earlier used substances, [20][21][22] and are now slowly gaining acceptance within the vitreoretinal community, [23][24][25][26][27] despite notable scepticism. In this article, the previous and current heavy tamponades, their indications, and the associated complications are reviewed.…”

Section: Introductionmentioning

confidence: 99%

Heavy tamponade 1: a review of indications, use, and complications

Heimann

Stappler

Wong

2008

Eye

116

125

View full text Add to dashboard Cite

Background Heavier than water intraocular tamponades have several theoretical advantages over conventional tamponades, especially in the treatment of complicated retinal detachments and proliferative viteroretinopathy of the lower fundus periphery. However, initial clinical series of various heavy tamponades have reported significant complication rates. Therefore, heavy tamponades have not found widespread acceptance. Three recently developed heavy silicone oil tamponades, Oxane HD, Densiron 68, and HWS 46-3000, are much better tolerated and presently seem to enter routine clinical practice. Materials and methods Literature review of 21 publications on the clinical application of 9 different heavy tamponades (fluorosilicone, C10F18, F6H8, OL62HV, Oxane HD, O62, F6H8-silicone oil mixture, Densiron 68, and HWS 46-3000). Results The first generation (fluorinated silicone and perfluorocarbon liquids) and second generation (partially fluorinated alkanes) of heavy tamponades were associated with relatively high complication rates, for example, tamponade emulsification, intraocular inflammation, and rise in intraocular pressure. The complication spectrum of the new generation of heavy silicone oils (Oxane HD, Densiron 68, and HWS 46-3000) seems to be comparable to conventional silicone oil tamponades while providing better support for the inferior retina and the posterior pole. Conclusion The recently developed heavy silicone oil tamponades are safe and effective tools for the use of complicated retinal detachments of the inferior fundus.

show abstract

“…Recent studies have shown good anatomical and visual outcomes with no emulsification upto 3 months with these agents. [28][29][30] HSO works well as a long-term tamponade agent for complex retinal detachments involving inferior proliferative vitreoretinopathy. 31 …”

Section: Heavy Silicone Oilmentioning

confidence: 99%