First experience of carbon-ion radiotherapy for early breast cancer

Akamatsu, Hiroko; Karasawa, Kumiko; Omatsu, Takashige; Isobe, Yoshiharu; Ogata, Risa; Koba, Yusuke

doi:10.1007/s11604-014-0300-6

Cited by 22 publications

(26 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accordingly, these ion beams bring about more cell cycle-and oxygenation-independent, irreparable DNA damage and eradicate more resistant cancer cells than conventional radiation [149,150]. Recently, a phase I clinical trial of early stage breast cancer treated with heavy ion irradiation noticed a limitations of dose escalation owing to adverse effects of skin, ribs, and lungs after carbon ion radiotherapy, particularly for some aggressive subtypes of breast cancer such as TNBC [30,151]. The authors considered that carbon ion beam combined with chemotherapy might decrease the dose of irradiation but preserve certain advantages to eliminate breast cancer [30,151].…”

Section: Carbon Ion Beam Combined With Cisplatin Effectively Disruptsmentioning

confidence: 99%

“…Recently, a phase I clinical trial of early stage breast cancer treated with heavy ion irradiation noticed a limitations of dose escalation owing to adverse effects of skin, ribs, and lungs after carbon ion radiotherapy, particularly for some aggressive subtypes of breast cancer such as TNBC [30,151]. The authors considered that carbon ion beam combined with chemotherapy might decrease the dose of irradiation but preserve certain advantages to eliminate breast cancer [30,151]. The combination of chemotherapy with heavy ion radiotherapy might open new means to counteract this challenging breast cancer subgroup which has poor prognosis and highly limited treatment choices.…”

Section: Carbon Ion Beam Combined With Cisplatin Effectively Disruptsmentioning

confidence: 99%

See 1 more Smart Citation

The impact of melatonin and carbon ion irradiation on cancer stem cells

Liu¹,

Reíter²

2017

Nucl Med Biomed Imaging

View full text Add to dashboard Cite

Aim: Cancer stem cells (CSCs) exhibited an excessive migratory and invasive potential. Melatonin may inhibit multiple crucial signals associated with tumor stem cell self-renewal, viability, invasiveness, tumor growth, and therapy resistance. Carbon ion irradiation may be a promising therapeutic modality in both non-stem-like and stem-like tumor cells in contrast to photon irradiation. A comprehensive understanding of the mechanisms and molecular pathways associated with invasive properties of CSCs is essential in developing novel treatment options for cancer therapy that target CSCs. Materials and methods:A systematic review of the existing literature was conducted using the following search terms: 'melatonin', 'X-ray irradiation', 'charged particle irradiation', 'carbon ion irradiation', 'cancer stem cells', 'tumor-initiating cells' and 'cancer stem-like cells'. The search used PubMed and spanned the period from January 2000 to December 2016. Conclusion:Cancer stem cells possess the capacity of self-renewal and pluripotency, generating all cells within a tumor, and are responsible for tumor growth, therapy resistance and metastasis. Melatonin attenuated AKT activation, EZH2 S21 phosphorylation, EZH2-STAT3 interactions and altered histone modifications to reduce tumor initiation and propagation of brain tumor stem cells (BTSC). Melatonin increases the efficacy of chemotherapeutic agents, targeting both the tumor bulk and BTSCs through the regulation of the expression and function of the ABCG2/BCRP transporter by inducing the methylation of its promoter. Melatonin treatment induced cell death with ultrastructural characteristics of autophagy. Breast cancer stem cells (BCSCs) are responsive to melatonin treatment by way of reducing the viability and the invasiveness of breast cancer mammospheres as well as regulating the expression of OCT4, N-cadherin and vimentin proteins associated with epithelial mesenchymal transition in BCSCs. Carbon irradiation is effective in brain tumor stem cell (BTSC) elimination with relative biologic effectiveness (RBE) in the range of 1.87-3.44. Carbon ion irradiation may be a promising therapeutic modality because it reduces migration and invasion processes in both head and neck squamous cell carcinoma and cancer stem cells in contrast to photon irradiation. Low LET X-ray irradiation may essentially eradicate the non-stem-like tumor cells, consequently the radioresistant cancer stem-like cell population is obviously enriched. In contrast, carbon ion irradiation may eradicate both non-stemlike and stem-like tumor cells at the same time. Carbon ion irradiation is a promising tool to eradicate putative colon cancer stem-like cells. Further investigation to elucidate the mechanisms and molecular pathways involved in cancer stem cells particularly associated with melatonin and carbon ion irradiation certainly is warranted.

show abstract

Section: Carbon Ion Beam Combined With Cisplatin Effectively Disruptsmentioning

confidence: 99%

Section: Carbon Ion Beam Combined With Cisplatin Effectively Disruptsmentioning

confidence: 99%

The impact of melatonin and carbon ion irradiation on cancer stem cells

Liu¹,

Reíter²

2017

Nucl Med Biomed Imaging

View full text Add to dashboard Cite

show abstract

“…However, this assessment 3 months after C-ion RT was then considered premature, based on the results of "Advanced Medicine" patients, and the Phase I study (UMIN ID000010848) of 7 patients was discontinued. Akamatsu et al had reported the treatment procedure and initial course of the rst case 10 , and the subsequent course is shown in Figure 1. In this patient, it took 24 months for tumor disappearance on MRI, but uorodeoxyglucose (FDG) positron emission tomography (PET) showed a signi cant reduction in accumulation at 2 months and complete disappeared at 9 months.…”

Section: Discussionmentioning

confidence: 99%

“…For position recognition, two ducial markers were inserted 5 mm from the upper and lower border of the intraductal extension. The details of preparation, positioning, and treatment planning were previously reported 10 . Gross tumor volume (GTV) was de ned as the volume of tumor based on contrast MRI ndings.…”

Section: Eligibility Criteriamentioning

confidence: 99%

A Clinical Study of Curative Partial Breast Irradiation for Stage I Breast Cancer using Carbon ion Radiotherapy

Karasawa¹,

Omatsu

Shiba

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background and purpose: Our institute initiated carbon ion radiotherapy research for patients with stage I breast cancer in April 2013. The purpose of this article is to evaluate the treatment outcome up to May 2020.Materials and methods: Eligibility criteria of the patients were having untreated stage I breast cancer and being unsuitable for operation for physical or mental reasons. The irradiated volume was defined as the gross tumor including intraductal components. The dose escalation study was initially conducted four times a week for a total of 52.8 Gy ([Relative Biological Efficacy (RBE)]). After confirming that adverse effects were within acceptable range, the total dose was increased to 60.0 Gy (RBE). Results: Between April 2013 and November 2015, 14 cases were treated. The median follow up period was 61 months. No adverse toxicities were observed except for grade 1 acute skin reaction in 10 cases. The time required from carbon-ion radiotherapy to tumor disappearance was 3 months in 1 case, 6 months in 3 cases, 12 months in 4 cases, and 24 months in 5 cases. The third case developed local recurrence 6 months after radiotherapy. Twelve patients with luminal subtype received 5-year endocrine therapy. Thirteen of 14 tumors have been maintaining complete response with excellent cosmetic results.Conclusions: The time from carbon ion radiotherapy to tumor disappearance was longer than expected, but complete tumor disappearance was observed except for one high-grade case. With careful patient selection, carbon-ion radiotherapy in patients with stage I breast cancer is deemed effective and safe, and further research is recommended.

show abstract

“…Tumors which are not good candidates for conventional radiotherapy: more than 1000 bone and soft tissue sarcomas, nearly 1000 melanomas, sarcomas, adenocarcinomas and related pathologies of head and neck tumors, more than 800 lung cancers, more than 500 liver tumors, nearly 500 pancreatic cancers, nearly 500 pelvic recurrences of rectal cancer, and more than 250 uterine cancers have been treated at NIRS [9]. Until 2011, a systemic approach for breast cancer by C-ion RT had not been carried out, as breast cancer has relatively good prognosis with other multivariate treatment modalities [10]. We started preparing for C-Ion RT for breast cancer in 2011, and started a The most important selection criterion of C-ion RT for recurrent tumors is the so-called oligometastasis, or whether the patient has other metastases that are well controlled by systemic treatment.…”

Section: Discussionmentioning

confidence: 99%

One shot of carbon-ion radiotherapy cured a 6-cm chemo-resistant metastatic liver tumor: a case of breast cancer

Harada

Karasawa²,

Yasuda³

et al. 2015

Jpn J Radiol

Self Cite

View full text Add to dashboard Cite

The standard treatment for metastatic liver tumor from breast cancer is systemic medical treatment, and there is controversy regarding the value of local treatment. However, there are some exceptional cases that do benefit from local therapy. We describe the case of a 54-year-old woman with systemic therapy-resistant liver metastasis from breast cancer successfully treated with a single shot of 36-GyE carbon-ion radiotherapy and surviving more than 8 years without local recurrence. This case represents a good example of the usefulness and safety of carbon-ion radiotherapy, and who might benefit from local therapy.

show abstract

First experience of carbon-ion radiotherapy for early breast cancer

Cited by 22 publications

References 8 publications

The impact of melatonin and carbon ion irradiation on cancer stem cells

The impact of melatonin and carbon ion irradiation on cancer stem cells

A Clinical Study of Curative Partial Breast Irradiation for Stage I Breast Cancer using Carbon ion Radiotherapy

One shot of carbon-ion radiotherapy cured a 6-cm chemo-resistant metastatic liver tumor: a case of breast cancer

Contact Info

Product

Resources

About