First experience in a synthesis of [β‐¹¹C]‐L‐3, 4‐dihydroxy phenylalanine via asymmetric alkylation of the nickel (II) complex of a schiff base of (S)‐O‐N‐[(N'‐benzylprolyl) amino]benzophenone and glycine with [¹¹C]‐3,4‐dimethoxybenzylbromide

The chemo- enzymatic synthesis of labeled l-amino acids and some of their derivatives

“…The literature data concerning the chemical and combined chemo- enzymatic synthesis of l -DOPA bearing 11 C-label are very tedious and were designed to obtain the products for PET diagnosis. Chemical [80, 81] and chemo-enzymatic [63] routes are applied for synthesis of [1- 14 C]- l -DOPA, as well as for obtaining of [2- 11 C]- l -DOPA [64, 82]. The old paper reports on the synthesis of uniformly ring labeled [U- 14 C]- l -DOPA using [U- 14 C]-phenol as a substrate [83].…”