First evidence of protein G-binding protein in the most primitive vertebrate: Serum lectin from lamprey (Lampetra japonica)

Xue, Zhuang; Pang, Yue; Liu, Xin; Zheng, Zizhan; Xiao, Rong; Jin, Minli; Han, Yinglun; Su, Peng; Lv, Li; Wang, Jihong; Li, Qingwei

doi:10.1016/j.dci.2013.06.010

Cited by 15 publications

(10 citation statements)

References 53 publications

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“…Intelectin family members have been identified in many species including cephalochordates, fish, amphibians and mammals [ 36 , 39 , 43 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ]. Expression patterns of intelectin family members vary among species.…”

Section: Introductionmentioning

confidence: 99%

Bovine Intelectin 2 Expression as a Biomarker of Paratuberculosis Disease Progression

Vázquez

Balseiro

Alonso‐Hearn

et al. 2021

Animals

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Paratuberculosis (PTB), a chronic granulomatous enteritis caused by Mycobacterium avium subsp. paratuberculosis (MAP), is responsible for important economic losses in the dairy industry. Our previous RNA-sequencing (RNA-Seq) analysis showed that bovine intelectin 2 (ITLN2) precursor gene was overexpressed in ileocecal valve (ICV) samples of animals with focal (log2 fold-change = 10.6) and diffuse (log2 fold-change = 6.8) PTB-associated lesions compared to animals without lesions. This study analyzes the potential use of ITLN2, a protein that has been described as fundamental in the innate immune response to infections, as a biomarker of MAP infection. The presence of ITLN2 was investigated by quantitative immunohistochemical analysis of ICV samples of 20 Holstein Friesian cows showing focal (n = 5), multifocal (n = 5), diffuse (n = 5) and no histological lesions (n = 5). Significant differences were observed in the mean number of ITLN2 immunostained goblet and Paneth cells between the three histopathological types and the control. The number of immunolabelled cells was higher in the focal histopathological type (116.9 ± 113.9) followed by the multifocal (108.7 ± 140.5), diffuse (76.5 ± 97.8) and control types (41.0 ± 81.3). These results validate ITLN2 as a post-mortem biomarker of disease progression.

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Section: Introductionmentioning

confidence: 99%

Bovine Intelectin 2 Expression as a Biomarker of Paratuberculosis Disease Progression

Vázquez

Balseiro

Alonso‐Hearn

et al. 2021

Animals

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“…84 Intelectin in arctic lamprey can agglutinate bacteria and fungi. 85 Injection of bacteria or dextran to the channel catfish (Icatalurus punctatus) did not significantly change the expression level of intelectin 1, but significantly upregulated the expression of intelectin 2. The expression of intelectin was upregulated in the liver of rainbow trout infected with Listonella anguillarum.…”

Section: Intelectin Genes Participate In Immune Defences Against Viral and Bacterial Infectionsmentioning

confidence: 96%

“…In catfish, intelectin can agglutinate bacteria, while Escherichia coli infection can cause an increase in the expression level of intelectins 84 . Intelectin in arctic lamprey can agglutinate bacteria and fungi 85 . Injection of bacteria or dextran to the channel catfish ( Icatalurus punctatus ) did not significantly change the expression level of intelectin 1, but significantly upregulated the expression of intelectin 2.…”

Section: Functions Of Intelectinmentioning

confidence: 99%

A comparative review of intelectins

Chen

Gao

2020

Scand J Immunol

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Intelectin (ITLN) is a new type of glycan‐binding lectin. It has been demonstrated to agglutinate bacteria probably due to its carbohydrate‐binding capacity, suggesting its role in an innate immune response. It is involved not only in many physiological processes but also in some human diseases such as asthma, heart disease, inflammatory bowel disease, chronic obstructive pulmonary disease and cancer. Up to now, intelectin orthologs have been identified in placozoans, urochordatas, cephalochordates and several vertebrates, such as cyclostomata, fish, amphibians and mammals. Although the sequences of intelectins in different species are conserved, their expression patterns, quaternary structures and functions differ considerably among and within species. We summarize the evolution of the intelectin gene family, the tissue distribution, structure and functions of intelectins. We conclude that intelectin plays a role in innate immune response and there are still potential functions of intelectin awaiting discovery.

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“…The expression was upregulated when challenged with S. cerevisiae. A serum lectin purified from Lampetra japonica (lamprey) by Xue et al (2013) was classified as an intelectin. The interlectin was a new type of extracellular animal lectins, being glycanbinding receptors which bind glycan epitopes on foreign pathogens in the host systems.…”

Section: Antifungal Activitymentioning

confidence: 99%

Marine lectins and their medicinal applications

Cheung

Wong

Pan

et al. 2015

Appl Microbiol Biotechnol

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Marine organisms have been extensively explored for the last several decades as potential sources of novel biologically active compounds, and extensive research has been conducted on lectins. Lectins derived from marine organisms are structurally diverse and also differ from those identified from terrestrial organisms. Marine lectins appear to be particularly useful in some biological applications. They seem to induce negligible immunogenicity because they have a relatively small size, are more stable due to extensive disulfide bridge formation, and have high specificity for complex glyco-conjugates and carbohydrates instead of simple sugars. It is clear that many of them have not yet been extensively studied when compared with their terrestrial counterparts. Marine lectins can be used to design and develop new potentially useful therapeutic agents. This review encompasses recent research on the isolation and identification of marine lectins with potential value in medicinal applications.

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First evidence of protein G-binding protein in the most primitive vertebrate: Serum lectin from lamprey (Lampetra japonica)

Cited by 15 publications

References 53 publications

Bovine Intelectin 2 Expression as a Biomarker of Paratuberculosis Disease Progression

Bovine Intelectin 2 Expression as a Biomarker of Paratuberculosis Disease Progression

A comparative review of intelectins

Marine lectins and their medicinal applications

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