First, do no harm: time for a systems approach to address the problem of health-care-derived pharmaceutical pollution

Thornber, Kelly; Adshead, Fiona; Balayannis, Angeliki; Brazier, Richard E.; Brown, Ross; Comber, Sean; Court, Caroline; Davidson, Iain; Depledge, Michael H.; Farmer, Caroline; Gibb, Stuart W.; Hixson, Richard; Kirchhelle, Claas; Moore, Keith M.; Motta, Marco; Niemi, Lydia; Owen, Stewart F.; Pencheon, David; Pfleger, Sharon; Pitchforth, Emma; Powell, Neil; Schmidt, Wiebke; Smith, Richard; Sowman, Georgina; Tyler-Batt, Wendy; Wilkinson, Helen; Wilson, Edward CF; Fleming, Lora E.; Gaze, William H.; Tyler, Charles R.

doi:10.1016/s2542-5196(22)00309-6

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…One tool being proposed to incentivize the pharmaceutical industry is green prescribing via green procurement practice. 17 Healthcare bodies are looking to establish league tables of medicine footprints and drive purchasing through those. For example, this is already happening in the U.K., where a choice of anesthetics 18 has been made based on the GHG warming potential and has effectively closed access to some active ingredients based on this.…”

Section: Pharmaceuticals That Could Limit Access To Medicinesmentioning

confidence: 99%

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Regulatory Highlights

Teasdale,

Owen

2024

Org. Process Res. Dev.

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Section: Pharmaceuticals That Could Limit Access To Medicinesmentioning

confidence: 99%

“…One tool being proposed to incentivize the pharmaceutical industry is green prescribing via green procurement practice . Healthcare bodies are looking to establish league tables of medicine footprints and drive purchasing through those.…”

Section: Environmental Challenges For Pharmaceuticals That Could Limi...mentioning

confidence: 99%

Regulatory Highlights

Teasdale,

Owen

2024

Org. Process Res. Dev.

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“…The scale and impact of novel entities, such as persistent organic pollutants (POPs), toward the sustainability of the planet’s ecosystem are poorly understood . Domains contributing to the impact on this planetary boundary include industrial manufacturing, the supply and quality of foods, and finished pharmaceutical products . The Chemical Abstracts Service (CAS, American Chemical Society) currently reports >200 million organic substances, alloys, coordination compounds, minerals, mixtures, polymers, and salts .…”

Section: Introductionmentioning

confidence: 99%

“… 1 Domains contributing to the impact on this planetary boundary include industrial manufacturing, 2 the supply and quality of foods, 3 and finished pharmaceutical products. 4 The Chemical Abstracts Service (CAS, American Chemical Society) currently reports >200 million organic substances, alloys, coordination compounds, minerals, mixtures, polymers, and salts. 5 Global production of many chemicals is increasing each year, exceeding our ability to assess the risk posed by these chemicals, which may lead to adverse impacts on the environment.…”

Section: Introductionmentioning

confidence: 99%

Online and Offline Prioritization of Chemicals of Interest in Suspect Screening and Non-targeted Screening with High-Resolution Mass Spectrometry

Szabo,

Falconer,

Fisher

et al. 2024

Anal. Chem.

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Recent advances in high-resolution mass spectrometry (HRMS) have enabled the detection of thousands of chemicals from a single sample, while computational methods have improved the identification and quantification of these chemicals in the absence of reference standards typically required in targeted analysis. However, to determine the presence of chemicals of interest that may pose an overall impact on ecological and human health, prioritization strategies must be used to effectively and efficiently highlight chemicals for further investigation. Prioritization can be based on a chemical's physicochemical properties, structure, exposure, and toxicity, in addition to its regulatory status. This Perspective aims to provide a framework for the strategies used for chemical prioritization that can be implemented to facilitate high-quality research and communication of results. These strategies are categorized as either "online" or "offline" prioritization techniques. Online prioritization techniques trigger the isolation and fragmentation of ions from the lowenergy mass spectra in real time, with user-defined parameters. Offline prioritization techniques, in contrast, highlight chemicals of interest after the data has been acquired; detected features can be filtered and ranked based on the relative abundance or the predicted structure, toxicity, and concentration imputed from the tandem mass spectrum (MS 2 ). Here we provide an overview of these prioritization techniques and how they have been successfully implemented and reported in the literature to find chemicals of elevated risk to human and ecological environments. A complete list of software and tools is available from https:// nontargetedanalysis.org/.

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