First diclofenac intoxication in a wild avian scavenger in Europe

Herrero‐Villar, Marta; Delepoulle, Émilie; Suárez, Laura; Solano-Manrique, Carlos; Juan‐Sallés, Carles; Iglesias-Lebrija, Juan José; Camarero, Pablo R.; González, F.; Álvarez, Ernesto; Mateo, Rafael

doi:10.1016/j.scitotenv.2021.146890

Cited by 28 publications

(12 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In agreement with results for raptor livers in Badry et al ( 2021 ), we did not detect the NSAID diclofenac. In contrast to Spain (see, e.g., Herrero-Villar et al 2021 ), diclofenac is not used as VMP in Germany, which seems to protect facultative scavengers from exposure.…”

Section: Discussionmentioning

confidence: 99%

Spatial variation of rodenticides and emerging contaminants in blood of raptor nestlings from Germany

Badry

Schenke

Brücher

et al. 2022

Environ Sci Pollut Res

View full text Add to dashboard Cite

Wildlife exposures to pest controlling substances have resulted in population declines of many predatory species during the past decades. Many pesticides were subsequently classified as persistent, bioaccumulative, and toxic (PBT) and banned on national or global scales. However, despite their risks for non-target vertebrate wildlife, PBT substances such as anticoagulant rodenticides (ARs) are still permitted for use in Europe and have shown to threaten raptors. Whereas risks of ARs are known, much less information is available on emerging agrochemicals such as currently used PPPs and medicinal products (MPs) in higher trophic level species. We expect that currently used PPPs are relatively mobile (vs. lipophilic) as a consequence of the PBT criteria and thus more likely to be present in aqueous matrices. We therefore analyzed blood of 204 raptor nestlings of three terrestrial (red kite, common buzzard, Montagu’s harrier) and two aquatic species (white-tailed sea eagle, osprey) from Germany. In total, we detected ARs in 22.6% of the red kites and 8.6% of the buzzards, whereas no Montagu’s harriers or aquatic species were exposed prior to sampling. ΣAR concentration tended to be higher in North Rhine-Westphalia (vs. North-Eastern Germany) where population density is higher and intense livestock farming more frequent. Among the 90 targeted and currently used PPPs, we detected six substances from which bromoxynil (14.2%) was most frequent. Especially Montagu’s harrier (31%) and red kites (22.6%) were exposed and concentrations were higher in North Rhine-Westphalia as well. Among seven MPs, we detected ciprofloxacin (3.4%), which indicates that risk mitigation measures may be needed as resistance genes were already detected in wildlife from Germany. Taken together, our study demonstrates that raptors are exposed to various chemicals during an early life stage depending on their sampling location and underpins that red kites are at particular risk for multiple pesticide exposures in Germany.

show abstract

Section: Discussionmentioning

confidence: 99%

Spatial variation of rodenticides and emerging contaminants in blood of raptor nestlings from Germany

Badry

Schenke

Brücher

et al. 2022

Environ Sci Pollut Res

View full text Add to dashboard Cite

show abstract

“…Evidence of accidental contamination has never been found by personnel in charge of the investigation, nor do landfills or garbage dumps occur where vultures could have been contaminated. Despite our small sample of NSAID- and lead-tested vultures being restricted in time, our effort allowed the reporting of the first-ever diclofenac-intoxicated Griffon Vulture in Italy, and the second intoxicated vulture in Europe, after the death of a juvenile Cinereous Vulture in Spain (Herrero-Villar et al 2021). In one case, clinical lead concentration was reported in the bones, which could have caused or contributed to death.…”

Section: Discussionmentioning

confidence: 99%

Reported mortality of Griffon VultureGyps fulvusin central Italy and indications for conservation and management

Posillico¹,

Costanzo

Bottoni

et al. 2023

Bird Conservation International

View full text Add to dashboard Cite

Summary Vultures are long-lived species sensitive to human-caused mortality that has already determined a widespread collapse in Asian and African populations. They provide significant ecosystem services (regulatory and cultural) consuming livestock carcasses and saving greenhouse gas emissions, favouring nutrient recycling, environmental sanitation, and providing financial revenue. Appraising the incidence and causes of mortality could help to improve management and conservation actions. We compiled records of reported mortalities for the reintroduced Griffon Vulture Gyps fulvus population of the central Apennines in Italy (123 cases, July 1994–December 2020). The average mortality was 4.69 vultures per year (± 1.14 SE), with no significant temporal trend. The peak of mortality events, estimated by harmonic regression analysis, was in March, while the minimum occurred in October. No differences were found among age classes and sex ratio mortality was established at 1.43:1 (M:F, N = 68). Out of 103 (83.7%) vultures which underwent a post-mortem and toxicological screening, 53% were poisoned, mainly by carbamates, and 27% died of unknown causes. Overall, direct or indirect anthropogenic mortality caused 67% of deaths. Even considering an inherent bias associated with reported mortality as to the prevalence of causes of death and estimation of mortality rates, the overwhelming relevance of poisoning highlights that existing anti-poisoning efforts should be refined and incorporated into a coordinated multidisciplinary strategy. A standardised approach, from vulture carcass discovery to post-mortem procedures and toxicological analysis, should be applied to reduce uncertainty in the determination of causes of death, increasing effectiveness in the prosecution of wildlife crimes. As most of the poisoning cases affecting the Griffon Vulture population in the central Apennines likely represent a side (though illegal) effect of retaliatory efforts to defeat livestock predators, effective strategies in reducing human–wildlife conflicts should be applied.

show abstract

“…In September 2020, a vulture chick was found dead in the nest. The autopsy revealed severe generalized joint and visceral gout, and diclofenac concentrations were detected at 26.5 and 51.4 ng/g in the liver and kidney, respectively [79].…”

Section: Environmental Health Impactmentioning

confidence: 99%

Rational Pharmacotherapy in Infectious Diseases: Issues Related to Drug Residues in Edible Animal Tissues

Cantón

Lanusse

Moreno

2021

Animals

View full text Add to dashboard Cite

Drugs are used in veterinary medicine to prevent or treat animal diseases. When rationally administered to livestock following Good Veterinary Practices (GVP), they greatly contribute to improving the production of food of animal origin. Since humans can be exposed chronically to veterinary drugs through the diet, residues in food are evaluated for effects following chronic exposures. Parameters such as an acceptable daily intake (ADI), the no-observed-adverse-effect level (NOAEL), maximum residue limits (MRLs), and the withdrawal periods (WPs) are determined for each drug used in livestock. Drug residues in food exceeding the MRLs usually appear when failing the GVP application. Different factors related either to the treated animal or to the type of drug administration, and even the type of cooking can affect the level of residues in edible tissues. Residues above the MRLs can have a diverse negative impact, mainly on the consumer’s health, and favor antimicrobial resistance (AMR). Drug residue monitoring programmes are crucial to ensure that prohibited or authorized substances do not exceed MRLs. This comprehensive review article addresses different aspects of drug residues in edible tissues produced as food for human consumption and provides relevant information contributing to rational pharmacotherapy in food-producing animals.

show abstract

First diclofenac intoxication in a wild avian scavenger in Europe

Cited by 28 publications

References 32 publications

Spatial variation of rodenticides and emerging contaminants in blood of raptor nestlings from Germany

Spatial variation of rodenticides and emerging contaminants in blood of raptor nestlings from Germany

Reported mortality of Griffon VultureGyps fulvusin central Italy and indications for conservation and management

Rational Pharmacotherapy in Infectious Diseases: Issues Related to Drug Residues in Edible Animal Tissues

Contact Info

Product

Resources

About