First detection of vanA positive Enterococcus faecium clonal complex 17 in hospital wastewater in Algeria: an epidemiological report

Cherak, Zineb; Bendjama, Esma; Moussi, A.; Benbouza, Amel; Grainat, Nadia; Rolain, Jean‐Marc; Loucif, Lotfi

doi:10.1016/j.nmni.2022.100977

Cited by 5 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…E. faecium CC17 can persist in aquatic environments polluted by sewage (Leclercq et al, 2013 ), including marine environments (Vignaroli et al, 2013 ). Hence, there is a risk that these MDR strains can persist in the marine environments in Norway (Cherak et al, 2022 ). Our study thus demonstrates that clinically important MDR strains of E. faecium carrying several ARGs and virulence genes are entering the marine environment in Norway through treated effluents.…”

Section: Discussionmentioning

confidence: 99%

Multidrug‐resistant Enterococcus faecium strains enter the Norwegian marine environment through treated sewage

Radisic,

Grevskott,

Junghardt

et al. 2024

MicrobiologyOpen

View full text Add to dashboard Cite

This study aimed to understand the antibiotic resistance prevalence among Enterococcus spp. from raw and treated sewage in Bergen city, Norway. In total, 517 Enterococcus spp. isolates were obtained from raw and treated sewage from five sewage treatment plants (STPs) over three sampling occasions, with Enterococcus faecium as the most prevalent (n = 492) species. E. faecium strains (n = 307) obtained from the influent samples, showed the highest resistance against quinupristin/dalfopristin (67.8%). We observed reduced susceptibility to erythromycin (30.6%) and tetracycline (6.2%) in these strains. E. faecium strains (n = 185) obtained from the effluent samples showed highest resistance against quinupristin/dalfopristin (68.1%) and reduced susceptibility to erythromycin (24.9%) and tetracycline (8.6%). We did not detect resistance against last‐resort antibiotics, such as linezolid, vancomycin, and tigecycline in any of the strains. Multidrug‐resistant (MDR) E. faecium strains were detected in both influent (2.3%) and effluent (2.2%) samples. Whole genome sequencing of the Enterococcus spp. strains (n = 25) showed the presence of several antibiotic resistance genes, conferring resistance against aminoglycosides, tetracyclines, and macrolides, as well as several virulence genes and plasmid replicons. Two sequenced MDR strains from the effluents belonged to the hospital‐associated clonal complex 17 and carried multiple virulence genes. Our study demonstrates that clinically relevant MDR Enterococcus spp. strains are entering the marine environment through treated sewage.

show abstract

Section: Discussionmentioning

confidence: 99%

Multidrug‐resistant Enterococcus faecium strains enter the Norwegian marine environment through treated sewage

Radisic,

Grevskott,

Junghardt

et al. 2024

MicrobiologyOpen

View full text Add to dashboard Cite

show abstract

“…From 28 different ARGs found in the hospital-adapted E. faecium clade, 23 were present in bloodstream infection, hospital sewage, and municipal WWTP enterococci, indicating a genetic overlap between isolates from all sectors and a potential ARG transmission route [148]. An additional study [149] detected vanA-positive E. faecium ST17 and ST80 (CC17) in hospital wastewater, once again highlighting the possible dissemination of healthcare-associated antimicrobial-resistant strains to the environment and community through wastewater. For instance, the ST78 strain from the vast CC17 was associated with isolates derived from WWTP samples, according to [107].…”

Section: Dissemination Of Genetic Traits Across One Health Sectorsmentioning

confidence: 94%

Dissemination of Enterococcal Genetic Lineages: A One Health Perspective

et al. 2023

View full text Add to dashboard Cite

Enterococcus spp. are commensals of the gastrointestinal tracts of humans and animals and colonize a variety of niches such as water, soil, and food. Over the last three decades, enterococci have evolved as opportunistic pathogens, being considered ESKAPE pathogens responsible for hospital-associated infections. Enterococci’s ubiquitous nature, excellent adaptative capacity, and ability to acquire virulence and resistance genes make them excellent sentinel proxies for assessing the presence/spread of pathogenic and virulent clones and hazardous determinants across settings of the human–animal–environment triad, allowing for a more comprehensive analysis of the One Health continuum. This review provides an overview of enterococcal fitness and pathogenic traits; the most common clonal complexes identified in clinical, veterinary, food, and environmental sources; as well as the dissemination of pathogenic genomic traits (virulome, resistome, and mobilome) found in high-risk clones worldwide, across the One Health continuum.

show abstract

“…11 (40.74%), 7 (28%), and 1 (1.69%), respectively, antibiotics called aminoglycosides. 28 Alexander et al in worked on Enterococcus raffinoses, Enterococcus durians, and Isolates of Enterococcus avium that were collected from the Romanian tertiary-care hospital. A (retrospective) study found that he performed antibiotic sensitivity by Vitek 2 compact and obtained 658 isolates of enterococcus involved in humans.…”

Section: Reviewmentioning

confidence: 99%

Enterococcus Species: A Systemic Review

Kalode¹,

Patil²

2023

J. Pure Appl. Microbiol.

View full text Add to dashboard Cite

Enterococci are gram-positive facultative anaerobes, these are commensals in the intestinal system of numerous animals, including humans. They affect hospitalized patients and cause nosocomial infections, respiratory infections, endocarditis, wound infections, UTIs, and other enterococcal infections. This discovery can be explained by hemolysin, gelatinase, aggregation substances, hyaluronidase, capsular polysaccharides, and cell wall carbohydrate. Various enterococcal spp. include Enterococcus avium Vancomycin resistance was acquired by enterococci throughout the antibacterial spectrum, primary antibiotic used regimen based on dual β lactams and aminoglycosides.

show abstract

First detection of vanA positive Enterococcus faecium clonal complex 17 in hospital wastewater in Algeria: an epidemiological report

Cited by 5 publications

References 22 publications

Multidrug‐resistant Enterococcus faecium strains enter the Norwegian marine environment through treated sewage

Multidrug‐resistant Enterococcus faecium strains enter the Norwegian marine environment through treated sewage

Dissemination of Enterococcal Genetic Lineages: A One Health Perspective

Enterococcus Species: A Systemic Review

Contact Info

Product

Resources

About