First detection of Rickettsia aeschlimannii in Hyalomma marginatum in Tibet, China

Jiao, Jun; Yu, Yonghui; He, Peisheng; Wan, Weiqiang; Ouyang, Xue; Wen, Bin; Sun, Yi; Xiong, Xiaolu

doi:10.15212/zoonoses-2022-0026

Cited by 3 publications

(1 citation statement)

References 53 publications

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“…However, their public health significance remains unclear, possibly due to these pathogens causing sporadic self-limiting diseases with non-specific symptoms such as fever, rash, and nausea. These symptoms are as mild as those caused by other Phlebovirus ( Travassos et al., 1983 ) and rickettsiae ( Jia et al., 2014 ; Jiao et al., 2022 ) infections, often termed self-healing diseases, with patients with the diseases less likely to be detected without active surveillance. At present, there are two methods to detect WUXV RNA ( Hu et al., 2022 ; Yao et al., 2022 ), but given the transient presence of viral nucleic acids, detecting viral genes within patients presents challenges.…”

Section: Discussionmentioning

confidence: 99%

Human and animal exposure to newly discovered sand fly viruses, China

Yao,

Yin,

Tian

et al. 2024

Front. Cell. Infect. Microbiol.

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IntroductionThe Hedi virus (HEDV) and Wuxiang virus (WUXV) are newly discovered Bunyaviruses transmitted by sandflies. The geographical distribution of isolation of these two viruses continues to expand and it has been reported that WUXV causes neurological symptoms and even death in suckling mice. However, little is known about the prevalence of the two viruses in mammalian infections.MethodsIn order to understand the infection status of HEDV and WUXV in humans and animals from regions where the viruses have been isolated, this study used Western blotting to detect the positive rates of HEDV and WUXV IgG antibodies in serum samples from febrile patients, dogs, and chickens in the forementioned regions.ResultsThe results showed that of the 29 human serum samples, 17.24% (5/29) tested positive for HEDV, while 68.96% (20/29) were positive for WUXV. In the 31 dog serum samples, 87.10% (27/31) were positive for HEDV and 70.97% (22/31) were positive for WUXV, while in the 36 chicken serum samples, 47.22% (17/36) were positive for HEDV, and 52.78% (19/36) were positive for WUXV.DiscussionThese findings suggest there are widespread infections of HEDV and WUXV in mammals (dogs, chickens) and humans from the regions where these viruses have been isolated. Moreover, the positive rate of HEDV infections was higher in local animals compared to that measured in human specimens. This is the first seroepidemiological study of these two sandfly-transmitted viruses. The findings of the study have practical implications for vector-borne viral infections and related zoonotic infections in China, as well as providing an important reference for studies on the relationship between sandfly-transmitted viruses and zoonotic infections outside of China.

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Section: Discussionmentioning

confidence: 99%

Human and animal exposure to newly discovered sand fly viruses, China

Yao,

Yin,

Tian

et al. 2024

Front. Cell. Infect. Microbiol.

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Meta-transcriptional Detection of Rickettsia canadensis from Ixodes persulcatus in China

Shi¹,

Qin²,

Liu³

et al. 2022

Preprint

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Genus Rickettsia associated to blood-feeding arthropods are usually pathogenic when transmitted to vertebrates. These species include the agents of acute human disease such as typhus and Rocky Mountain spotted fever. However, many other Rickettsia have been uncovered with uncertain pathogenic to vertebrates in recent surveys. It is therefore perhaps more appropriate to consider these Rickettsiaas endosymbionts that are transmitted vertically in invertebrates, and secondarily as pathogens of vertebrates. Rickettsia canadensis, an ancestor species in genus Rickettsia, had been well characterized for its peculiar genome size and genes’ contents bridging the pathogenic Rickettsiaand non-pathogenic ones. However, there is few research on the ancient rickettsia species in China which may seriously influence our pursue for the evolutionary nature of Rickettsia in China. In the present study, R. canadensis was detected from Ixodes persulcatusticks from forest areas of both Heilongjiang province and Inner Mongolia Autonomous Region in northern China. The molecular evidences from both 16S rRNA gene and 3 arrays of gene transcripts strongly indicated the natural infection of R. canadensis occurs in Ixodid ticks in China. The gene transcripts including rpoB-rpoC-rpoC/160KDa-leucyl aminopeptidase-hypothetical protein-leucyl aminopeptidase-aspartate tRNA ligase, RlmE-Omp 1-Peptidase M50-nusB, dnaK-dnaJ-ChaBfamily protein-BamD-RecN-Carboxypeptidase M32 revealed from I. persulcatus suggested the intensive interactions between R. canadensis and. host ticks, which would provide scientific clues to highlight the possible evolutionary trajectory of Rickettsia species in China.

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Wolbachia infection in field-collected Aedes aegypti in Yunnan Province, southwestern China

Zhang

Gao²,

Ma³

et al. 2022

Front. Cell. Infect. Microbiol.

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BackgroundWolbachia is gram-negative and common intracellular bacteria, which is maternally inherited endosymbionts and could expand their propagation in host populations by means of various manipulations. Recent reports reveal the natural infection of Wolbachia in Aedes Aegypti in Malaysia, India, Philippines, Thailand and the United States. At present, none of Wolbachia natural infection in Ae. aegypti has been reported in China.MethodsA total of 480 Ae. aegypti adult mosquitoes were collected from October and November 2018 based on the results of previous investigations and the distribution of Ae. aegypti in Yunnan. Each individual sample was processed and screened for the presence of Wolbachia by PCR with wsp primers. Phylogenetic trees for the wsp gene was constructed using the neighbour-joining method with 1,000 bootstrap replicates, and the p-distance distribution model of molecular evolution was applied.Results24 individual adult mosquito samples and 10 sample sites were positive for Wolbachia infection. The Wolbachia infection rate (IR) of each population ranged from 0 - 41.7%. The infection rate of group A alone was 0%-10%, the infection rate of group B alone was 0%-7.7%, and the infection rate of co-infection with A and B was 0-33.3%.ConclusionsWolbachia infection in wild Ae. aegypti in China is the first report based on PCR amplification of the Wolbachia wsp gene. The Wolbachia infection is 5%, and the wAlbA and wAlbB strains were found to be prevalent in the natural population of Ae. aegypti in Yunnan Province.

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First detection of Rickettsia aeschlimannii in Hyalomma marginatum in Tibet, China

Cited by 3 publications

References 53 publications

Human and animal exposure to newly discovered sand fly viruses, China

Human and animal exposure to newly discovered sand fly viruses, China

Meta-transcriptional Detection of Rickettsia canadensis from Ixodes persulcatus in China

Wolbachia infection in field-collected Aedes aegypti in Yunnan Province, southwestern China

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